Protein Alignment CG6701 and Dna2

DIOPT Version :10

• Sequence 1: NP_610920.3
• Gene: CG6701 / 36550
• FlyBaseID: FBgn0033889
• Length: 1333
• Species: Drosophila melanogaster
• Sequence 2: NP_796346.2
• Gene: Dna2 / 327762
• MGIID: 2443732
• Length: 1062
• Species: Mus musculus
• Alignment Length: 996
• Identity: 215/996 - (21%)
• Similarity: 379/996 - (38%)
• Gaps: 283/996 - (28%)

  Fly   178 IEEYKLDTDVKPTLLKFQKRLLLQSDKDFELQSLGCYICQENFEKIEKYEEHVEYHGDESDFQSL 242
            ::|..|.|..:...||...||.|..|:      :.|.: :|......|:.|.....|..|:|..:
Mouse   180 LQELALQTLREVRHLKEMYRLNLSQDE------ILCEV-EEYLPSFSKWAEDFMRKGPSSEFPQM 237

  Fly   243 K-------KMKKYPTPI---VSLSYQTCVDSHYFG-------------------------FTLKT 272
            :       ..:..|..|   .||..:..:.|..||                         ..|||
Mouse   238 QLSLPSDGSNRSSPCNIEVVKSLDIEESIWSPRFGLKGKIDVTVGVKIHRDCKMKYKVMPLELKT 302

  Fly   273 --------FRKDLVVDKFIIVQLRQ-------FYYVYGAQMPLPVN--GSGELV----FFVDSHV 316
                    .|..:|:...:..:.|:       .|...|...|:|.|  ...||:    :...|.:
Mouse   303 GKESNSIEHRSQVVLYTLLSQERREDPEAGWLLYLKTGQMYPVPANHLDKRELLKLRNWLAASLL 367

  Fly   317 FMILREQPIVIGFTIQGEKYVEQHHFMRTEALP---------KASFNINPYRLSSKETFKSKGLP 372
            ..:.|..|        ||:       .|..|||         |....|....|.|: ..:.:| .
Mouse   368 HRVSRAAP--------GEE-------ARLSALPQIIEEEKTCKYCSQIGNCALYSR-AVEEQG-D 415

  Fly   373 PANPPIQVLSALKHEDAQMCLA-----------------SFDNQ--YQN-YCERGREITQE-NLT 416
            .|:.|..:||.::.|...:.||                 |.||:  :|: :.....|:.:. |..
Mouse   416 DASIPEAMLSKIQEETRHLQLAHLKYFSLWCLMLTLESQSKDNRKTHQSIWLTPASELEESGNCV 480

  Fly   417 GTLRTLLQVEDIERL---QHYLSLKQSEMELHQFGRELSVKMQMGTTSMSVED--ILSPGDDVLI 476
            |   .|::.|.:.|:   |:          ||.|.|:   ...|..|::...|  |||..:..|.
Mouse   481 G---NLVRTEPVSRVCDGQY----------LHNFQRK---NGPMPATNLMAGDRIILSGEERKLF 529

  Fly   477 INEKG----NPKSAVRKMLENNNNVLELALKDFDSILRWARNVDGMVGSLDKQPRVYFARILGVS 537
            ...||    ..|:||..:|:.|.:.|...     ::.|           ||::.|..     .:|
Mouse   530 ALSKGYVKKMNKAAVTCLLDRNLSTLPAT-----TVFR-----------LDREERHG-----DIS 573

  Fly   538 TQRVNITCERQLPDNTTYTLIFRPLRAVMRYQYRALQQLSFTRHSDVQRILFPGEIPNTPLASGV 602
            |...|::   :|.::|..:   :.||.:: ..:|..|.:::...      :.|.:..:|
Mouse   574 TPLGNLS---KLMESTDPS---KRLRELI-IDFREPQFIAYLSS------VLPHDAKDT------ 619

  Fly   603 LQLNNKLISTNPEQMQAVRQIALSPRLKAPYIVFGPPGTGKTSTIVEAIYQLYINRPETHILVLA 667
              :.|.|...|..|.||::::.||   |...::.|.||||||:||. |:.:: ::.....:|:.:
Mouse   620 --VANILKGLNKPQRQAMKRVLLS---KDYTLIVGMPGTGKTTTIC-ALVRI-LSACGFSVLLTS 677

  Fly   668 GSNTACDEVALRLLRAIAKAPQSQPRPLTRIFSANCDRRIDNIDDLLLEYSNMYTVHFYPAVQAV 732
            .:::|.|.:.|:|.:                |...           .|.....:.||  |.:|..
Mouse   678 YTHSAVDNILLKLAK----------------FKVG-----------FLRLGQSHKVH--PDIQKF 713

  Fly   733 HQYRIV----ICTLSLAGKL-------STGGFAANN------VYTHVFVDEAAASTEAEVLMGIT 780
            .:..|.    |.:|:...:|       :|.....|:      .:....||||:..:: .|.:|
Mouse   714 TEEEICRSRSIASLAHLEELYNSHPIVATTCMGINHPIFSRKTFDFCIVDEASQISQ-PVCLG-- 775

  Fly   781 CTLSPTLNLILSGDHKQLGPVLQSQRANEWGLGLTLFERLLQRKCYQVEEDGSYNASVQTRLIRN 845
             .|..:...:|.|||:||.|::.::.|...|:..:||:||            ..|.|...:|...
Mouse   776 -PLFFSRRFVLVGDHQQLPPLVVNREARALGMSESLFKRL------------ERNESAVVQLTVQ 827

  Fly   846 FRSHPEIVSLYNNMYYEGHLR--TEAPMEIVCRFHNWFYLPNATFPIMFHSVFGTT--------- 899
            :|.:.:|:||.|.:.|.|.|.  ::.....|....|   |.:|...:..::.:..:
Mouse   828 YRMNRKIMSLSNKLTYAGKLECGSDRVANAVLALPN---LKDARLSLQLYADYSDSPWLAGVLEP 889

  Fly   900 ------MNTK--------SSVSLCNNKEIDVVMDYVKDLMYFGLNGEKLLQTDIGIISPYKNQYQ 950
                  :||.        .:..:.|..|..:::......:..|.:     .:|||:|:||:.|.:
Mouse   890 DNPVCFLNTDKVPAPEQVENGGVSNVTEARLIVFLTSTFIKAGCS-----PSDIGVIAPYRQQLR 949

  Fly   951 RIQEQLNMRNWSQIDCGSVELFQGKEKHVIIVSFVRSFTP-KLG-FLNNERRLNVLLSRPISLLI 1013
            .|.:.|...:...::..:|:.:||::|.:|:||||||... .|| .|.:.|||||.|:|....||
Mouse   950 IISDLLARSSVGMVEVNTVDKYQGRDKSLILVSFVRSNEDGTLGELLKDWRRLNVALTRAKHKLI 1014

  Fly  1014 LIGNPRTLSQ----NSDFQHI 1030
            |:|:..:|.:    .:.|.|:
Mouse  1015 LLGSVSSLKRFPPLGTLFDHL 1035

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6701	NP_610920.3	DEXXQc_Helz-like	611..847	CDD:350796	57/252 (23%)
		SF1_C_Upf1	848..1035	CDD:350195	53/214 (25%)
Dna2	NP_796346.2	Nuclease activity. /evidence=ECO:0000250	82..520		75/379 (20%)
		DNA2_N-like	127..366	CDD:411722	36/192 (19%)
		Helicase activity. /evidence=ECO:0000250	521..1062		139/615 (23%)
		P-loop containing Nucleoside Triphosphate Hydrolases	572..>675	CDD:476819	30/128 (23%)
		DEXXQc_DNA2	626..829	CDD:350799	57/252 (23%)
		AAA_12	806..1020	CDD:463780	58/233 (25%)