DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6701 and Dna2

DIOPT Version :9

Sequence 1:	NP_001188923.1	Gene:	CG6701 / 36550	FlyBaseID:	FBgn0033889	Length:	1333	Species:	Drosophila melanogaster
Sequence 2:	NP_796346.2	Gene:	Dna2 / 327762	MGIID:	2443732	Length:	1062	Species:	Mus musculus

Alignment Length:	996	Identity:	215/996 - (21%)
Similarity:	379/996 - (38%)	Gaps:	283/996 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 IEEYKLDTDVKPTLLKFQKRLLLQSDKDFELQSLGCYICQENFEKIEKYEEHVEYHGDESDFQSL 242
            ::|..|.|..:...||...||.|..|:      :.|.: :|......|:.|.....|..|:|..:
Mouse   180 LQELALQTLREVRHLKEMYRLNLSQDE------ILCEV-EEYLPSFSKWAEDFMRKGPSSEFPQM 237

  Fly   243 K-------KMKKYPTPI---VSLSYQTCVDSHYFG-------------------------FTLKT 272
            :       ..:..|..|   .||..:..:.|..||                         ..|||
Mouse   238 QLSLPSDGSNRSSPCNIEVVKSLDIEESIWSPRFGLKGKIDVTVGVKIHRDCKMKYKVMPLELKT 302

  Fly   273 --------FRKDLVVDKFIIVQLRQ-------FYYVYGAQMPLPVN--GSGELV----FFVDSHV 316
                    .|..:|:...:..:.|:       .|...|...|:|.|  ...||:    :...|.:
Mouse   303 GKESNSIEHRSQVVLYTLLSQERREDPEAGWLLYLKTGQMYPVPANHLDKRELLKLRNWLAASLL 367

  Fly   317 FMILREQPIVIGFTIQGEKYVEQHHFMRTEALP---------KASFNINPYRLSSKETFKSKGLP 372
            ..:.|..|        ||:       .|..|||         |....|....|.|: ..:.:| .
Mouse   368 HRVSRAAP--------GEE-------ARLSALPQIIEEEKTCKYCSQIGNCALYSR-AVEEQG-D 415

  Fly   373 PANPPIQVLSALKHEDAQMCLA-----------------SFDNQ--YQN-YCERGREITQE-NLT 416
            .|:.|..:||.::.|...:.||                 |.||:  :|: :.....|:.:. |..
Mouse   416 DASIPEAMLSKIQEETRHLQLAHLKYFSLWCLMLTLESQSKDNRKTHQSIWLTPASELEESGNCV 480

  Fly   417 GTLRTLLQVEDIERL---QHYLSLKQSEMELHQFGRELSVKMQMGTTSMSVED--ILSPGDDVLI 476
            |   .|::.|.:.|:   |:          ||.|.|:   ...|..|::...|  |||..:..|.
Mouse   481 G---NLVRTEPVSRVCDGQY----------LHNFQRK---NGPMPATNLMAGDRIILSGEERKLF 529

  Fly   477 INEKG----NPKSAVRKMLENNNNVLELALKDFDSILRWARNVDGMVGSLDKQPRVYFARILGVS 537
            ...||    ..|:||..:|:.|.:.|...     ::.|           ||::.|..     .:|
Mouse   530 ALSKGYVKKMNKAAVTCLLDRNLSTLPAT-----TVFR-----------LDREERHG-----DIS 573

  Fly   538 TQRVNITCERQLPDNTTYTLIFRPLRAVMRYQYRALQQLSFTRHSDVQRILFPGEIPNTPLASGV 602
            |...|::   :|.::|..:   :.||.:: ..:|..|.:::...      :.|.:..:|
Mouse   574 TPLGNLS---KLMESTDPS---KRLRELI-IDFREPQFIAYLSS------VLPHDAKDT------ 619

  Fly   603 LQLNNKLISTNPEQMQAVRQIALSPRLKAPYIVFGPPGTGKTSTIVEAIYQLYINRPETHILVLA 667
              :.|.|...|..|.||::::.||   |...::.|.||||||:||. |:.:: ::.....:|:.:
Mouse   620 --VANILKGLNKPQRQAMKRVLLS---KDYTLIVGMPGTGKTTTIC-ALVRI-LSACGFSVLLTS 677

  Fly   668 GSNTACDEVALRLLRAIAKAPQSQPRPLTRIFSANCDRRIDNIDDLLLEYSNMYTVHFYPAVQAV 732
            .:::|.|.:.|:|.:                |...           .|.....:.||  |.:|..
Mouse   678 YTHSAVDNILLKLAK----------------FKVG-----------FLRLGQSHKVH--PDIQKF 713

  Fly   733 HQYRIV----ICTLSLAGKL-------STGGFAANN------VYTHVFVDEAAASTEAEVLMGIT 780
            .:..|.    |.:|:...:|       :|.....|:      .:....||||:..:: .|.:|
Mouse   714 TEEEICRSRSIASLAHLEELYNSHPIVATTCMGINHPIFSRKTFDFCIVDEASQISQ-PVCLG-- 775

  Fly   781 CTLSPTLNLILSGDHKQLGPVLQSQRANEWGLGLTLFERLLQRKCYQVEEDGSYNASVQTRLIRN 845
             .|..:...:|.|||:||.|::.::.|...|:..:||:||            ..|.|...:|...
Mouse   776 -PLFFSRRFVLVGDHQQLPPLVVNREARALGMSESLFKRL------------ERNESAVVQLTVQ 827

  Fly   846 FRSHPEIVSLYNNMYYEGHLR--TEAPMEIVCRFHNWFYLPNATFPIMFHSVFGTT--------- 899
            :|.:.:|:||.|.:.|.|.|.  ::.....|....|   |.:|...:..::.:..:
Mouse   828 YRMNRKIMSLSNKLTYAGKLECGSDRVANAVLALPN---LKDARLSLQLYADYSDSPWLAGVLEP 889

  Fly   900 ------MNTK--------SSVSLCNNKEIDVVMDYVKDLMYFGLNGEKLLQTDIGIISPYKNQYQ 950
                  :||.        .:..:.|..|..:::......:..|.:     .:|||:|:||:.|.:
Mouse   890 DNPVCFLNTDKVPAPEQVENGGVSNVTEARLIVFLTSTFIKAGCS-----PSDIGVIAPYRQQLR 949

  Fly   951 RIQEQLNMRNWSQIDCGSVELFQGKEKHVIIVSFVRSFTP-KLG-FLNNERRLNVLLSRPISLLI 1013
            .|.:.|...:...::..:|:.:||::|.:|:||||||... .|| .|.:.|||||.|:|....||
Mouse   950 IISDLLARSSVGMVEVNTVDKYQGRDKSLILVSFVRSNEDGTLGELLKDWRRLNVALTRAKHKLI 1014

  Fly  1014 LIGNPRTLSQ----NSDFQHI 1030
            |:|:..:|.:    .:.|.|:
Mouse  1015 LLGSVSSLKRFPPLGTLFDHL 1035

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6701	NP_001188923.1	TIGR00376	424..1037	CDD:273041	150/664 (23%)
		AAA_19	618..687	CDD:289986	20/68 (29%)
		AAA_12	812..1019	CDD:289832	58/233 (25%)
Dna2	NP_796346.2	Dna2	72..283	CDD:285859	23/109 (21%)
		Nuclease activity. /evidence=ECO:0000250	82..520		75/379 (20%)
		Cas4_I-A_I-B_I-C_I-D_II-B	<256..398	CDD:294426	28/156 (18%)
		TIGR00376	472..1034	CDD:273041	153/677 (23%)
		Helicase activity. /evidence=ECO:0000250	521..1062		139/615 (23%)
		P-loop_NTPase	626..830	CDD:304359	57/253 (23%)
		AAA_12	806..1020	CDD:289832	58/233 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831392
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740