DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6701 and Upf1

DIOPT Version :9

Sequence 1:	NP_001188923.1	Gene:	CG6701 / 36550	FlyBaseID:	FBgn0033889	Length:	1333	Species:	Drosophila melanogaster
Sequence 2:	NP_001285145.1	Gene:	Upf1 / 32153	FlyBaseID:	FBgn0030354	Length:	1180	Species:	Drosophila melanogaster

Alignment Length:	757	Identity:	201/757 - (26%)
Similarity:	309/757 - (40%)	Gaps:	185/757 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   377 PIQVLSALKHEDAQMCLASFDNQYQ-----------NYCERGRE-ITQENL-----------TGT 418
            |..||  |::||..        ||:           .|.::.:| .||||:           |..
  Fly   266 PAHVL--LRYEDGY--------QYEKTFGPLVRLEAEYDQKLKESATQENIEVRWDVGLNKKTIA 320

  Fly   419 LRTLLQVEDIERLQHYLSLKQSEMELHQFGRELSVKMQMGTTSMSVEDILSPGDDVLIINEKGNP 483
            ..||.:.:...:|.|     ..|:.||..|...:...::|.. :.|.|  :.||||.:
  Fly   321 YFTLAKTDSDMKLMH-----GDELRLHYVGELYNPWSEIGHV-IKVPD--NFGDDVGL------- 370

  Fly   484 KSAVRKMLENNNNVLELALKDFDSILRWARNVDGMVGSLDKQPRVYFARILGVSTQRVNITCERQ 548
                  .|:::.|.......:|.....|      ...|.|:..|.               .|:..
  Fly   371 ------ELKSSTNAPVKCTSNFTVDFIW------KCTSFDRMTRA---------------LCKFA 408

  Fly   549 LPDNTTYTLIFRPLRAVMRYQYRALQQLSFTRHSDVQRILFPGEIPNTPLASGVLQLNNKLISTN 613
            :..|:....|:..|             |...|......:||.|..|....|..:..||.
  Fly   409 IDRNSVSNFIYSRL-------------LGHGRADSNDEVLFRGPQPKLFSAPHLPDLNR------ 454

  Fly   614 PEQMQAVRQIALSPRLKAPY-IVFGPPGTGKTSTIVEAIYQLYINRPETH---ILVLAGSNTACD 674
             .|:.||:.     .|:.|. ::.||||||||.|....:|||.    :.|   :||.|.||||.|
  Fly   455 -SQVYAVKH-----ALQRPLSLIQGPPGTGKTVTSATIVYQLV----KLHGGTVLVCAPSNTAVD 509

  Fly   675 EVA-------LRLLRAIAKAPQSQPRPLTRIFSANCDRRIDNIDDLL-----------------L 715
            ::.       |:::|..||:.::...|::.:...|..|.::...:|.                 .
  Fly   510 QLTEKIHRTNLKVVRVCAKSREAIDSPVSFLALHNQIRNMETNSELKKLQQLKDETGELSSADEK 574

  Fly   716 EYSNMYTVHFYPAVQAVHQYRIVICTLSLAGKLSTGGFAANNVYTHVFVDEAAASTEAEVLMGIT 780
            .|.|:........::|..   ::.||...||    .|..:...:|.:.:||:..|||.|.::.:.
  Fly   575 RYRNLKRAAENQLLEAAD---VICCTCVGAG----DGRLSRVKFTSILIDESMQSTEPECMVPVV 632

  Fly   781 CTLSPTLNLILSGDHKQLGPVLQSQRANEWGLGLTLFERL--LQRKCYQVEEDGSYNASVQTRLI 843
            ....   .|||.|||.|||||:..::|...||..:|||||  |..:.:::|        ||
  Fly   633 LGAK---QLILVGDHCQLGPVVMCKKAARAGLSQSLFERLVVLGIRPFRLE--------VQ---- 682

  Fly   844 RNFRSHPEIVSLYNNMYYEGHLRTEAPMEIVC----RFHNWFYLPNATFPIMFHSVFGTTMNTKS 904
              :|.|||:....:|.:|||.|:..     ||    |....|..|....|:.|....|......|
  Fly   683 --YRMHPELSQFPSNFFYEGSLQNG-----VCAEDRRLKLDFPWPQPERPMFFLVTQGQEEIAGS 740

  Fly   905 SVSLCNNKEIDVVMDYVKDLMYFGLNGEKLLQTDIGIISPYKN------QYQRIQEQLNMRNWSQ 963
            ..|..|..|...|.......:..|:..|:     ||||:||:.      ||.:.|..|:.|.:.:
  Fly   741 GTSFLNRTEAANVEKITTRFLKAGIKPEQ-----IGIITPYEGQRAYLVQYMQYQGSLHSRLYQE 800

  Fly   964 IDCGSVELFQGKEKHVIIVSFVRSFTPK-LGFLNNERRLNVLLSRPISLLILIGNPRTLSQNSDF 1027
            |:..||:.|||:||.:||:|.|||...: :||||:.|||||.|:|....:|::|||:.|::...:
  Fly   801 IEIASVDAFQGREKDIIIMSCVRSNERQGIGFLNDPRRLNVALTRAKFGIIIVGNPKVLAKQQLW 865

  Fly  1028 QHIIEMCRNRKTLVGEQYLN---EDFI--TNKKTGANNVNKG 1064
            .|::...::||.|| |..||   |..|  ...|...|::|.|
  Fly   866 NHLLNFYKDRKVLV-EGSLNNLKESLIHFQKPKKLVNSMNIG 906

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6701	NP_001188923.1	TIGR00376	424..1037	CDD:273041	171/653 (26%)
		AAA_19	618..687	CDD:289986	28/79 (35%)
		AAA_12	812..1019	CDD:289832	73/219 (33%)
Upf1	NP_001285145.1	UPF1_Zn_bind	98..249	CDD:286500
		DNA2	122..897	CDD:224037	197/746 (26%)
		Mis12	210..299	CDD:283509	9/42 (21%)
		AAA_19	458..>515	CDD:289986	25/65 (38%)
		AAA_12	661..857	CDD:289832	73/219 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438981
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D27889at6960
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.750