Protein Alignment CG6701 and Dna2

DIOPT Version :10

• Sequence 1: NP_610920.3
• Gene: CG6701 / 36550
• FlyBaseID: FBgn0033889
• Length: 1333
• Species: Drosophila melanogaster
• Sequence 2: NP_727386.1
• Gene: Dna2 / 31934
• FlyBaseID: FBgn0288690
• Length: 1100
• Species: Drosophila melanogaster
• Alignment Length: 1209
• Identity: 237/1209 - (19%)
• Similarity: 437/1209 - (36%)
• Gaps: 384/1209 - (31%)

  Fly    63 EMARLQVISAQTEWYVDKAKMRKLFEVHLNALPNSS--EIRQKLSSQG----------------A 109
            ::|.:..:.:.:...::..|.::...|.|..|||..  ::..|..|.|                .
  Fly    51 DLALIAAMDSISNHRLELTKWQRCEVVRLEQLPNRKGLKVHVKRISGGDPETADCQLLPPWNCMP 115

  Fly   110 TNIG---SLLHRTN-----FLINTPRG----NPNYRIKNFSLMD--FRKEKFNLLDEQHRLRGIA 160
            ..:|   |||.:.:     ::::..:|    :|::.|...::..  |.|.|..|   |.|.||:.
  Fly   116 MQVGDTVSLLGKWDPSAGCYVVDKEQGYCVSHPDFLISGTTVTGSLFCKRKSVL---QERFRGLD 177

  Fly   161 STTDVPGGAPAEGNKPIIEEYKLDTDVKPTLLKFQKRLL-----LQS--DKDFELQSLGCYICQE 218
            |           ||..::    :.|.|...|.|..::.|     :||  .:.....||...:...
  Fly   178 S-----------GNSVMV----IGTLVHELLQKVLRQKLFDKKHIQSALQEMLASSSLAHLLYAS 227

  Fly   219 NFEKIEKYEEHVEYHGDESDFQSLKKMKKYPTPIVSL---------------------SYQTC-- 260
            |..::| .|:|               :.|:..||||.                     .::.|
  Fly   228 NLIQVE-MEDH---------------LMKFIDPIVSFVAQYVKGEPPSVLLPEVYRGQIHEICDI 276

  Fly   261 --------------VD-----------SHYFGFTLKTFRKDLVVD---KFIIVQLRQ-------- 289
                          ||           .......|||.|....::   :.::.||..
  Fly   277 EENLWVPQLGLKGKVDVSVKVKNQRQREEIIPLELKTGRASFSMEHKGQLLLYQLMHSAQGRDTQ 341

  Fly   290 ---FYYVYGAQMPLPVNGSGE---LVFFVDSHVFMILREQPIVIGFTIQGEKYVEQ--------H 340
               ..|:....:....:|..|   |:...:...:.:.||    :......|..:||        |
  Fly   342 SGLLLYLKEGLLREVASGRNEQRDLLMLRNDLAYWLTRE----VAIPASKEDPLEQLPLPEPVYH 402

  Fly   341 HFMRTEALPKASFNINPYRLSSKETFKSKGLPPANPPIQVL-SALKHEDAQMCLASFDNQY-QNY 403
            |    .|....::|......:.|::  |..|..::|..::: ..|:|      |:..|:.| |::
  Fly   403 H----SACGNCAYNTICSSFAQKDS--SLQLSDSHPLKKLMPQLLEH------LSEADHAYVQHW 455

  Fly   404 CERGREITQENLTGT-LRTLLQVEDIERLQHYLSLKQSEMELHQFGRELSVKMQMGTTSMSVEDI 467
            |.......|.|...: :|:....:..||.:..::::..::          ||.|        |.|
  Fly   456 CGLLALEEQHNRQSSHVRSFWTKDPAEREKEGIAIRHLKL----------VKGQ--------EVI 502

  Fly   468 LSPG--DDVLIINEKGNPKSAVRKMLENNNNVLELALKDFDSILRWARNVDGMVGSLDKQPRVYF 530
            |..|  ...|.:.|:.:|..             :|:|..||.         |....:....|:..
  Fly   503 LEEGRYRQTLELGEEADPSR-------------DLSLSGFDL---------GEYVVISSTSRLAV 545

  Fly   531 AR--ILGVSTQRVNITCERQLPDN-TTYTLIFRPLRAVMRYQYRALQQLSFT----------RHS 582
            |.  |:.:..:|:::..||.|... :..|.|      :.::..::....:||          |..
  Fly   546 AAGFIVSIEARRLDLRLERDLSQRYSEETFI------IDKHDSQSFATFNFTNLGMLLSEGERFQ 604

  Fly   583 DVQRILF---PGE----IPNTPLASGV-LQLN-NKLISTNPEQMQAVRQIALSPRLKAPYIVFGP 638
            :::.|:.   |.|    :|...|..|. :.|| ||:     :|..|:|.:..|..|    ::.|.
  Fly   605 ELRDIIVAKKPPEQHKVLPKIILTKGAPILLNLNKV-----QQNAALRALTTSSHL----LIKGL 660

  Fly   639 PGTGKTSTIVEAIYQLYINRPETHILVLAGSNTACDEVALRLLRAIAKAPQSQP--RPLTRIFS- 700
            ||||||.|:|..:..|::....  :|:.|.:::|.|.:.:|||          |  .|:.|:.|
  Fly   661 PGTGKTQTLVALVRLLHLLGKS--VLITAQTHSAVDNLIMRLL----------PFGLPMMRLGSG 713

  Fly   701 ANCDRRIDNIDDLLLEYSNMYTVHFYPAVQAVHQYRIVICTLSLAGKLSTG---GFAANNVYTHV 762
            :...::::.|.:..|...          .:.|.:....:...|:.|....|   .......:.:.
  Fly   714 SRIHKQLEEISEERLTKD----------CKTVEELEKALGQPSIVGVTCLGCGHPLFQRRQFDYC 768

  Fly   763 FVDEAAASTEAEVLMG-ITCTLSPTLNLILSGDHKQLGPVLQSQRANEWGLGLTLFERLLQRKCY 826
            .||||....:..||.. |.|:     ..:|.||.:||.|:::|:.|.:.|...|||:||...|..
  Fly   769 IVDEATQVLQPTVLRPLIHCS-----KFVLVGDPEQLPPIVRSKEARQRGADETLFQRLDSEKAT 828

  Fly   827 QVEEDGSYNASVQTRLIRNFRSHPEIVSLYNNMYYEGHLRTEA--------PMEIVCRFHNWF-- 881
            .|             |...:|.:..|..|.|.:.|.|.|:..:        .:|::.....|.
  Fly   829 AV-------------LSLQYRMNKTITRLANELTYGGDLKCASDEVSGARFEVELLNEAPRWVQR 880

  Fly   882 ----YLPNATFPIMFHSVFGTTMNTKSSVSLC--------------------------------- 909
                :|..|.          |.:||...:..|
  Fly   881 ALTTHLEQAV----------TLINTGDCLERCQEFVYASQRLVDTCSSIEQSFSEDKDEIRKLTS 935

  Fly   910 --------NNKEIDVVMDYVKDLMYFGLNGEKLLQTDIGIISPYKNQ---YQRIQEQLNMRNWSQ 963
                    |..|..:||..::.|:..|....:     ||:|:||:.|   ::::..:|:    :.
  Fly   936 KKRVSKYTNYCEAGIVMHLLRYLLKSGYEASR-----IGVIAPYRAQVELFKKLASKLD----TD 991

  Fly   964 IDCGSVELFQGKEKHVIIVSFVRS---FTP-----KLGFLNNERRLNVLLSRPISLLILIGNPRT 1020
            ::|.:|:.|||::|::||.|..::   |:.     :...|.::|||.|.::|..:.|||:|:.:.
  Fly   992 LECNTVDQFQGRDKNLIIYSCSKTGGDFSDMERSREAEILEDQRRLTVAITRAKNKLILLGDIKC 1056

  Fly  1021 LSQNSD----FQHIIEMCRNR----KTLVGEQYLNEDFI 1051
            |.|...    |:||.:.||.:    :...|.|.:.||.:
  Fly  1057 LEQYGPFRQLFKHIPDRCRLKLEEGRMEFGWQRIQEDLV 1095

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6701	NP_610920.3	DEXXQc_Helz-like	611..847	CDD:350796	57/242 (24%)
		SF1_C_Upf1	848..1035	CDD:350195	52/256 (20%)
Dna2	NP_727386.1	DNA2_N-like	153..378	CDD:411722	42/258 (16%)
		DEXXQc_DNA2	636..836	CDD:350799	60/248 (24%)
		AAA_12	815..1055	CDD:463780	56/271 (21%)