DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6701 and Mov10

DIOPT Version :9

Sequence 1:	NP_001188923.1	Gene:	CG6701 / 36550	FlyBaseID:	FBgn0033889	Length:	1333	Species:	Drosophila melanogaster
Sequence 2:	NP_001101181.1	Gene:	Mov10 / 310756	RGDID:	1598327	Length:	1004	Species:	Rattus norvegicus

Alignment Length:	1077	Identity:	288/1077 - (26%)
Similarity:	454/1077 - (42%)	Gaps:	242/1077 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 NLLDEQHRLRGIASTTDVPG-GAPAEG----------------NKPIIEEYKLD--TDVKPTLLK 193
            :|..::.|||.|.:....|. |.||.|                .|..:..:|||  .||:   |.
  Rat    27 DLETDRERLRAIYNRDFKPSYGTPAPGFSSMLYGMKIANLAFVTKTRVRFFKLDRWADVQ---LP 88

  Fly   194 FQKRLLLQSDKDFELQSLGCYICQENFEKIE-KYEEHVEYHG--DESDFQSLKKMKKYPTPIVSL 255
            .::|:...|....:.:||...|..:..|.:. |:...||..|  :..|.|.|.::......:::|
  Rat    89 EKRRIKPGSSISKQHRSLLARIFHDRAEYLHGKHGVDVEVQGPHEARDGQLLIRLDLNRKEVLTL 153

  Fly   256 SYQTCVDSHYFGFTLKTFRKDLVVDKFIIVQLRQFYYVYGAQ-MPLPVNGSGELVFFVDSHVFMI 319
            ..:.       |.|    :...:...|.:....||.:.:|.| :|.|: |.||   ..:.||:.
  Rat   154 RLRN-------GGT----KPVTLTHLFPLCWTPQFVFYHGEQDLPCPL-GPGE---SYELHVYC- 202

  Fly   320 LREQPIVIGF---TI---------QGEKYVEQHHFMRTEALPKASFNINPYRLSSKET--FKSKG 370
               :..::|:   |:         .|.:..|..:..|..|....|    |.....|.|  ||.
  Rat   203 ---KTSIVGYFPATVLWELLGPGESGAEGAETFYIARFLAAVAHS----PLAAQLKPTTPFKR-- 258

  Fly   371 LPP---ANPPIQVLSALKHEDAQMCLASFDNQYQNYCERGREITQENLTGT----------LRTL 422
             ||   .||    :|..:.|:.:          :....:|.|:......||          |.||
  Rat   259 -PPRLTRNP----VSTNRIEEGE----------RPDRAKGYELELSLALGTYYPPIRLRQLLPTL 308

  Fly   423 LQVEDIERLQHYLSLKQSEMELHQFGRELSVKMQMGTTSMSVEDILSPGDDVLIINEKGNPKSAV 487
            ||...|     :.|.|:          ...:|.|:.||..|                 .|.:..:
  Rat   309 LQGPSI-----FTSPKE----------VAEIKAQLETTLKS-----------------RNYEVKL 341

  Fly   488 RKMLENNNNVLELALK--DFDSI-LRWARNVDGMVGSLDKQPRVYFARILGVSTQRVNI------ 543
            |.:|......:|..::  |.:|: :.|        ..:|:.||:....:.||:..|.::
  Rat   342 RLLLHLEELQMEHDIRHYDLESVPMTW--------DPVDQNPRLLTLEVPGVTESRPSVLRGDHL 398

  Fly   544 ----TCERQLPDNTTY------------TLIFRPL------------------RAVMRYQYRALQ 574
                :.|.|..|..||            .|.|.|.                  |..:|.|:|||:
  Rat   399 FALLSSEIQQEDPVTYKGFVHKVELDRVKLSFSPSLLSRFVDGLTFKVNFTFNRQPLRVQHRALE 463

  Fly   575 QLSFTRHSDVQRILFPGEIPNTPLAS-GV--------LQLNNKLISTNPEQMQAVRQIALSPRLK 630
            ...       :.:|:|...   |:|| ||        .:|.::.:.:||||:||::.|.......
  Rat   464 LTG-------RWVLWPTLF---PVASRGVSLLPSDVKFKLYDRSLESNPEQLQAMKHIVRGTTRP 518

  Fly   631 APYIVFGPPGTGKTSTIVEAIYQLYINRPETHILVLAGSNTACDEVALRLLRAIAKAPQSQPRPL 695
            ||||:|||||||||.|:||||.|:..:.|:.|||....||:..|.:..||...:       |..:
  Rat   519 APYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACTPSNSGADLLCQRLRVHL-------PSSI 576

  Fly   696 TRIFSANCDRRI--------DNIDDLLLEYSNMYTVHFYPAVQAVHQYRIVICTLSLAGKLSTGG 752
            .|:.:.:.|.|:        .|.|....||       .|||.:.:.|||::|.||..|.:|.:..
  Rat   577 YRLLAPSRDIRMVPEDIKTCCNWDPKKGEY-------VYPAKKHLQQYRVLITTLITASRLVSAQ 634

  Fly   753 FAANNVYTHVFVDEAAASTEAEV------LMGITCTLSPTLNLILSGDHKQLGPVLQSQRANEWG 811
            |..:: :||:|:|||....|.|.      ||.:..|.:|...|:|:||.:||||||:|..|.:.|
  Rat   635 FPIDH-FTHIFIDEAGHCMEPESLVAIAGLMDVKETGNPGGQLVLAGDPRQLGPVLRSPLAQKHG 698

  Fly   812 LGLTLFERLLQRKCYQVEEDGSYNASVQTRLIRNFRSHPEIVSLYNNMYYEGHLRTEAPMEIVCR 876
            ||.:|.||||.......:....|:....|:|:||:||||.|:.:.|.:||:|.|:..|.:....|
  Rat   699 LGYSLLERLLTYNSLYKKGPNGYDPQFITKLLRNYRSHPTILDIPNQLYYDGELQACADVVDRER 763

  Fly   877 FHNWFYLPNATFPIMFHSVFGTTMNTKSSVSLCNNKEIDVVMDYVKDLMY-FGLNGE-KLLQTDI 939
            |..|..||...|||:||.|.|......:|.|..|.:|...|..|::.|:. ....|: :|....:
  Rat   764 FCRWEGLPQQGFPIIFHGVMGKDEREGNSPSFFNPEEAATVTSYLRQLLAPSSKKGKARLSPRSV 828

  Fly   940 GIISPYKNQYQRI--------QEQLNMRNWSQIDCGSVELFQGKEKHVIIVSFVRSFTP------ 990
            |:||||:.|.::|        :|...:.:...:..||||.|||:|:.||::|.|||...
  Rat   829 GVISPYRKQVEKIRYCITKLDRELRGLDDIKDLKVGSVEEFQGQERSVILISTVRSSQSFVQLDL 893

  Fly   991 --KLGFLNNERRLNVLLSRPISLLILIGNPRTLSQNSDFQHIIEMCRNRKTLVGEQYLNEDFITN 1053
              .||||.|.:|.||.::|..:|||::|||..|..:.|::..:|.|:......|..:..:..:..
  Rat   894 DFNLGFLKNPKRFNVAVTRAKALLIVVGNPLLLGHDPDWKTFLEFCKENGGYTGCPFPAKLDLQQ 958

  Fly  1054 KKTGANNVNKGGAAGDQPASGLRQPLKRKNHAKNPVQ 1090
            .:.....::|...:...|....|.|.:|:.....|:|
  Rat   959 GQDLLQGLSKLSPSTSGPRRHQRLPQEREGEEGLPLQ 995

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6701	NP_001188923.1	TIGR00376	424..1037	CDD:273041	209/696 (30%)
		AAA_19	618..687	CDD:289986	31/68 (46%)
		AAA_12	812..1019	CDD:289832	80/224 (36%)
Mov10	NP_001101181.1	DEXXQc_Helz-like	499..734	CDD:350796	92/249 (37%)
Mov10	NP_001101181.1	SF1_C_Upf1	735..940	CDD:350195	71/204 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148890at33208
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101029
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.680