DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6701 and Mov10l1

DIOPT Version :9

Sequence 1:	NP_001188923.1	Gene:	CG6701 / 36550	FlyBaseID:	FBgn0033889	Length:	1333	Species:	Drosophila melanogaster
Sequence 2:	XP_017450774.2	Gene:	Mov10l1 / 300141	RGDID:	1304735	Length:	1291	Species:	Rattus norvegicus

Alignment Length:	1058	Identity:	267/1058 - (25%)
Similarity:	434/1058 - (41%)	Gaps:	265/1058 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 NALPNSSEI-----------RQK--LSSQGATNIGSLL---HRTNFLINTPRGNPNYRIKNFSLM 140
            ::|.|::||           |:|  .:.:.....|.|:   .:|:.::.....||. |.|...|:
  Rat   360 SSLENNTEISPDGCACTEESREKGDTAEKQEPEPGGLIPPGEKTSIVVTCNAKNPG-RCKELLLL 423

  Fly   141 DF------RKEKFNLLDEQHRLRGI-----------------ASTT------------DVPGGAP 170
            .|      |..:.|::..:..|..:                 |.||            .:|...|
  Rat   424 CFSNFLIGRHLEVNVVSSEEALIAVREPFSWKKPKSSQTIVSAKTTVVVTTQKRNSRRQLPSFLP 488

  Fly   171 AEGNKPIIEEYKLDTDVKPTLLKFQKRLLLQSDKDFELQSLGCYICQENFEKIEKYEE-HVE--- 231
               ..||.:..|...:.|..:|.||..|.       ||.::..|  :|.|..:...|| |.|
  Rat   489 ---QYPIPDRLKKCVEQKIDILTFQPLLA-------ELLNMSNY--KEKFSTLLWLEEIHAEIEL 541

  Fly   232 -------------------------------YHGDESDFQSLKKMKKYPTPIVSLSYQTCVDSHY 265
                                           |.||    :.:.|.::|...::          .|
  Rat   542 KEYNMSGVVLKRKGELLVLEVPGLAESRPSLYAGD----KLILKSQEYNGHVI----------EY 592

  Fly   266 FGFTLKTFRKDLVVDKFIIVQLRQ-FYYVYGAQMPLPVNGSGELVFFVDSHVFMILREQPIVIGF 329
            .|:.::...:|      :.::|.. |..:|..: |:.|..:.........|..:   ||.|.:|.
  Rat   593 IGYVMEIHEED------VTLKLNPGFEQMYNFE-PMDVEFTYNRTTSRRCHYAL---EQVIHLGV 647

  Fly   330 TIQ-GEKYVEQHHFMRTEALPKASFNINPYRLSSKETFKSKGLPPANPPIQVLSALKHEDAQMCL 393
            .:. .|:.:.|.        |:.:.|     .|..:..||.|        |.::.:...|.|
  Rat   648 KVLFPEEIILQS--------PQVTGN-----WSLAQDTKSDG--------QSITKVTRNDGQ--- 688

  Fly   394 ASFDNQYQNYCERGREITQENLT---GTLRTLLQVEDIERLQHYLSLKQSEMELHQFGRELSVKM 455
             |..|..:|   .|:.||  |:|   |...|.:...|   .|...::.:::      |:.::...
  Rat   689 -SITNITKN---DGQSIT--NITKNDGQSITKVTKND---GQSITNITKND------GQSITSIT 738

  Fly   456 QMGTTSMSVEDILSPGDDVLIINEKGNPKSAVRKMLENNNNVLELALKDFDSILRWARNVDGMVG 520
            :.|..|::.   ::..|...|.|...|...::.|:.:|..          .||.:..|| ||.
  Rat   739 KNGGQSINK---VTRNDGQSITNITRNDGQSITKVTKNGG----------QSISKVTRN-DGQ-- 787

  Fly   521 SLDKQPRVYFARILGVSTQRVNITCERQL-----PDNTTYTLIFRPLRAVMRYQYRALQQLSFTR 580
            |:.|..:.       |..|..|.|.||.|     |:.|..|.             ..:.::...|
  Rat   788 SITKNKKT-------VKDQTKNTTKERHLSTTDQPEKTASTA-------------ETMDEIQIPR 832

  Fly   581 HSDVQRILFPGEIPNTPLASGVLQLNNKLISTNPEQMQAVRQIALSPRLKAPYIVFGPPGTGKTS 645
            ..|.:            ..:.||..|.||         |||:|........|||:|||||||||.
  Rat   833 ARDKE------------FFNPVLNENQKL---------AVRRILSGDCRPLPYILFGPPGTGKTV 876

  Fly   646 TIVEAIYQLYINRPETHILVLAGSNTACDEVALRLLRAIAKAPQSQPRPLTRIFSANCDRRIDNI 710
            ||:||:.|::...|::.|||.|.||:|.|.|.|||    .::...:|..:.|: :|.|     ..
  Rat   877 TIIEAVLQVHYALPDSRILVCAPSNSAADLVCLRL----HESKVLKPAAMVRV-NATC-----RF 931

  Fly   711 DDLLLEYSNMYTVHFYPAVQAVHQYRIVICTLSLAGKLSTGGFAANNVYTHVFVDEAAASTEAEV 775
            ::.::|....| ......:....::||:|.|.|.||.....|... ..:||||||||..::|.|.
  Rat   932 EETIIEAIKPY-CRDGEDIWRASRFRIIITTCSSAGLFYQIGVRV-GYFTHVFVDEAGQASEPEC 994

  Fly   776 LMGITCTLSPTLNLILSGDHKQLGPVLQSQRANEWGLGLTLFERLLQRKCYQVEED-----GSYN 835
            |:.:.........::|:||..|||||::|:.|..:||.:::.|||:.|..|..:|:     |:||
  Rat   995 LIPLGLISDINGQIVLAGDPMQLGPVIKSRLAMAYGLNVSMLERLMSRPAYLRDENAFGACGAYN 1059

  Fly   836 -------ASVQ-TRLIRNFRSHPEIVSLYNNMYYEGHLRTEAPMEIVCRFHNWFYLPNATFPIMF 892
                   :|.| |:|::|:|||..:::|.:.::|...|...|..::|.....|..||...||::|
  Rat  1060 PLLPLPASSPQVTKLVKNYRSHSALLALPSRLFYHRELEVCADPKVVTSLLGWEKLPRKGFPLIF 1124

  Fly   893 HSVFGTTMNTKSSVSLCNNKEIDVVMDYVKDLMYFGLN-GEKLLQTDIGIISPYKNQYQRIQEQL 956
            |.|.|.......|.|..:..|...||.|   ......| ..::...|||:|:||:.|.::|:..|
  Rat  1125 HGVRGNEAREGRSPSWFSPAEAVQVMRY---CCLLARNVSSQVSSKDIGVITPYRKQVEKIKILL 1186

  Fly   957 NMRNWSQIDCGSVELFQGKEKHVIIVSFVRSFTPK-------LGFLNNERRLNVLLSRPISLLIL 1014
            ...:.:.|..||||.|||:|..||::|.|||...:       ||||:|.:|.||.::||.:|||:
  Rat  1187 RNVDLTDIKVGSVEEFQGQEYLVIVISTVRSNEDRFEDDRYFLGFLSNSKRFNVAITRPKALLIV 1251

  Fly  1015 IGNPRTLSQNSDFQHIIE 1032
            :|||..|.::..|..::|
  Rat  1252 LGNPHVLVRDPCFGALLE 1269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6701	NP_001188923.1	TIGR00376	424..1037	CDD:273041	188/635 (30%)
		AAA_19	618..687	CDD:289986	34/68 (50%)
		AAA_12	812..1019	CDD:289832	78/227 (34%)
Mov10l1	XP_017450774.2	PRK08581	657..>833	CDD:236304	49/250 (20%)
		DEXXQc_Mov10L1	842..1079	CDD:350836	90/257 (35%)
		SF1_C_Upf1	1080..1270	CDD:350195	66/193 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335126
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148890at33208
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101029
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.750