DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6701 and Ighmbp2

DIOPT Version :9

Sequence 1:	NP_001188923.1	Gene:	CG6701 / 36550	FlyBaseID:	FBgn0033889	Length:	1333	Species:	Drosophila melanogaster
Sequence 2:	NP_113774.2	Gene:	Ighmbp2 / 29532	RGDID:	68325	Length:	988	Species:	Rattus norvegicus

Alignment Length:	882	Identity:	199/882 - (22%)
Similarity:	350/882 - (39%)	Gaps:	188/882 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   424 QVEDIERLQHYLSLKQSE------MELHQFG---------------RELSVKMQMGTTSMSVEDI 467
            :||:....|.:.|||:.:      ::|...|               |:....:.:.:.|.:..||
  Rat    24 EVEERRSWQEHSSLKELQSRGVCLLKLQVSGQRTGLYGQRLVTFEPRKFGPAVVLPSNSFTSGDI 88

  Fly   468 LSPGDDVLIINEKGNPKSAVRKMLENNNNVLELALKDFDSILRWARNVDGMVGSLDKQPRVYFAR 532
            :...|    .||.....:.|...:...:.::.     ||....:..|:|        :...|  |
  Rat    89 VGLYD----TNESSQLATGVLTRITQKSVIVA-----FDESHDFQLNLD--------RENTY--R 134

  Fly   533 ILGVSTQRVNITCERQLPDNTTYTLIFRPLRAVMRYQYRALQQLSFTRH----SDVQRILFPGEI 593
            :|             :|.::.||..:.:.|..:.:|            |    |.:..:|..|..
  Rat   135 LL-------------KLANDVTYKRLKKALLTLKKY------------HSGPASSLIDVLLGGST 174

  Fly   594 PNTPLASGVLQLNNKLISTNPEQMQAVRQIALSPRLKAPYIVFGPPGTGKTSTIVEAIYQLYINR 658
            |:.......|...|..:  :|.|.:|| ..||:.:..|  |:.||||||||:|:||.|.|..  :
  Rat   175 PSPATEIPPLTFYNTTL--DPSQKEAV-SFALAQKEVA--IIHGPPGTGKTTTVVEIILQAV--K 232

  Fly   659 PETHILVLAGSNTACDEVALRL-------LR------------------AIAKAPQSQ-----PR 693
            ....:|..|.||.|.|.:..||       ||                  .:|::..:|     .|
  Rat   233 QGLKVLCCAPSNIAVDNLVERLALCKKQILRLGHPARLLESVQQHSLDAVLARSDNAQIVADIRR 297

  Fly   694 PLTRIFSAN---CDRRIDN--IDDLLLEYSNMYTVHFYPAVQAVHQYRIVICTLSLAGKLSTGG- 752
            .:.::|..|   .|:|..:  .:::.|....:........||::....:|:.|.:.|   ||.|
  Rat   298 DIDQVFGKNKKTQDKREKSNFRNEIKLLRKELKEREEAAIVQSLSAADVVLATNTGA---STDGP 359

  Fly   753 --FAANNVYTHVFVDEAAASTEAEVLMGITCTLSPTL---NLILSGDHKQLGPVLQSQRANEWGL 812
              ....:.:..|.|||.|.:.||      :|.: |.|   ..||:||||||.|...|.:|...||
  Rat   360 LKLLPEDYFDVVVVDECAQALEA------SCWI-PLLKAPKCILAGDHKQLPPTTVSHKAALAGL 417

  Fly   813 GLTLFERLLQRKCYQVEEDGSYNASVQTRLIRNFRSHPEIVSLYNNMYYEGHLRTEAPMEIVCRF 877
            ..:|.|||.::          :.|:|...|...:|.|..|....:...|.|.|.....:    ..
  Rat   418 SRSLMERLAEK----------HGAAVVRMLAVQYRMHQAITRWASEAMYHGQLTAHPSV----AG 468

  Fly   878 HNWFYLP------NATFPIMFHSVFG---TTMNTKSSVSLCNNKEIDVVMDYVKDLMYFGLNGEK 933
            |....||      ..:.|::.....|   ..:..:.|.|..|..|:.:|..:::.|:..|:..
  Rat   469 HLLKDLPGVADTEETSVPLLLIDTAGCGLLELEEEDSQSKGNPGEVRLVTLHIQALVDAGVQA-- 531

  Fly   934 LLQTDIGIISPYKNQYQRIQEQLNMRNWSQIDCGSVELFQGKEKHVIIVSFVRSFTP-KLGFLNN 997
               .||.:|:||..|...:::.|:.:: .:::..||:.|||:||..:|::||||... ::|||..
  Rat   532 ---GDIAVIAPYNLQVDLLRQSLSNKH-PELEIKSVDGFQGREKEAVILTFVRSNRKGEVGFLAE 592

  Fly   998 ERRLNVLLSRPISLLILIGNPRTLSQNSDFQHIIE-MCRNRKTLVGEQYLNEDFITNKKTGANNV 1061
            :||:||.::|....:.:|.:..|::.::..:.::: ...:.:.....:|| :|.:....|...:.
  Rat   593 DRRINVAVTRARRHVAVICDSHTVNNHAFLKTLVDYFTEHGEVRTAFEYL-DDIVPENYTHEGSR 656

  Fly  1062 NKGGAAGDQ-PASGLRQPLKRKNHAKNPVQDAKIF--YSKNELLN--LGNECQRKKSELETIFDE 1121
            :...|...: |.:.:|:|..    |:...|:|:..  :|:.:...  ||::.|.:.|......|.
  Rat   657 SHSCAPKPKCPTTSVRKPAS----AQESRQEARAATGHSRRKPSEKPLGSQVQPQHSSKANGSDR 717

  Fly  1122 LPKVPRSVDHDLDEVRSIEAQLKDFQLETKQDAAGTSILVTNAPVTNAAAPSVIPRAGLMKQETP 1186
            .....|: :|....:....|. |:.|||.....:....|                |...:.:|..
  Rat   718 TGGTDRT-EHFRAMIEEFVAS-KEAQLEFPTSLSSHDRL----------------RVHQLAEEFG 764

  Fly  1187 ALHSSSVSRPAIRKPTVSAATPVAK-SRSPMPEIPSS 1222
            ..|.|:....| |..|||..:|... |.:|.|..|.|
  Rat   765 LKHDSTGEGKA-RHITVSRRSPAGSGSATPQPPSPPS 800

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6701	NP_001188923.1	TIGR00376	424..1037	CDD:273041	159/689 (23%)
		AAA_19	618..687	CDD:289986	30/93 (32%)
		AAA_12	812..1019	CDD:289832	54/216 (25%)
Ighmbp2	NP_113774.2	TIGR00376	19..640	CDD:273041	159/696 (23%)
		SS DNA-binding. /evidence=ECO:0000250	637..783		34/169 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	651..722		14/74 (19%)
		R3H_Smubp-2_like	724..782	CDD:100070	15/76 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	765..820		13/37 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	835..872
		Nuclear localization signal. /evidence=ECO:0000255	857..861
		ZnF_AN1	890..930	CDD:197545
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	943..988
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810