DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6701 and sen1

DIOPT Version :9

Sequence 1:	NP_001188923.1	Gene:	CG6701 / 36550	FlyBaseID:	FBgn0033889	Length:	1333	Species:	Drosophila melanogaster
Sequence 2:	NP_594119.1	Gene:	sen1 / 2541556	PomBaseID:	SPAC6G9.10c	Length:	1687	Species:	Schizosaccharomyces pombe

Alignment Length:	1328	Identity:	271/1328 - (20%)
Similarity:	446/1328 - (33%)	Gaps:	486/1328 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 NSSEIRQKL--SSQGATNIGSLL-----------HRTNFLINTPRGNPNYRIKNFSLMDFRKEKF 147
            :|:||...|  ||:..|.:..||           |....:.|..: |.|..:|....|||
pombe   498 SSTEISNMLGDSSKFDTVVSFLLSPTQPLYVSAFHIVQIITNCTK-NRNEALKKLVAMDF----- 556

  Fly   148 NLLDEQHRLRGIASTTDVPGGAPAEGN-KPIIEEYKLDTDVKPTL-----LKFQKRLLLQSDKDF 206
                     |||     |.|.|.|..| :.|:..:       |.|     |....:.|...:..|
pombe   557 ---------RGI-----VHGLADAVLNWQSILSFF-------PALRIMRFLSITNKSLSSDNSAF 600

  Fly   207 ---ELQSLGCY------ICQENFEKIEKYEEH-------------VEYHGD--ESDFQSLKKMKK 247
               ::.:||.|      |....|..:.::..:             :::..|  ::|...:|.:.|
pombe   601 TENDIPTLGAYWQCIWNILDLVFSNVARWSLNNPADTVKALMKLTLKFVDDLFQNDGIFIKLLAK 665

  Fly   248 YPTPIVSLSYQTCVDSHYFGFTLKTFRKDLVVDKFII-------VQLRQFYYVYGAQMPLPVNGS 305
            :.:.|  |..:|  ....|.|.:.....||.:...:|       .:...|.|::..:
pombe   666 FDSLI--LLGET--SESLFSFIMWLKINDLELRGIVINSLCKLFTKFSNFDYLFEDR-------- 718

  Fly   306 GELVFFVDSHVFMILREQPIVIGFTIQGEKYVEQHHFMRTEALPKASFNINPYRLSS-KETFKSK 369
             .:.|..|    .|:|:|...:     .....:|...:.|:|.|:|...:..:|||. ::|.|..
pombe   719 -TVTFLTD----FIIRKQKAHL-----SADQCKQLANVLTQASPEAKTVLEQHRLSEMRKTKKQT 773

  Fly   370 GL--------PPANPPIQVLSALKHEDAQMCLASFDNQYQNYCERGREITQENLTGTLR------ 420
            .|        |...|.|.|........:...:...:...|.|      :|:.|....|:
pombe   774 ELTNSAHVIKPSPTPQITVKQNTTKSSSAPRMGMLEQLKQEY------LTKRNFESKLKSSAVSS 832

  Fly   421 ---TLLQV--------------EDIERLQHYLSLKQSEM--ELHQFGRELSVKMQMGTTSMSVED 466
               |..:|              :||:|.|...||.::..  |:.|..|.....:...|..|
pombe   833 RKPTFNEVKPANLLAEDLSDNEDDIDRKQGLFSLAKANKIPEIRQQERRQVQLLSNSTIKM---- 893

  Fly   467 ILSPGDDVLIINEKGNPKSAVRKMLENNNNVLELALKDFDS-------ILRWA------------ 512
                           :| |.:|.|  .|.||..:..:.|.|       ||.|.
pombe   894 ---------------HP-SQIRMM--TNRNVANVKARLFPSMTDFYKEILSWEPANQSPNPVLKF 940

  Fly   513 RNVDGMVGSLDKQPRVYFARILGVSTQRVNITCERQLPDNTTYTLIFRPLRAVMRYQYRALQQLS 577
            ..:||.:....|....|    :.|....:.:.|..|: .:|...|.|.|:..:|      :::.:
pombe   941 HKLDGKIIDSFKTVEHY----MEVLQPMIFMECWSQI-QSTKLDLKFSPVEGIM------VERTA 994

  Fly   578 FTRHSDVQRILFPGEIPNTPL---------------------------------ASGVL------ 603
            .....|:...:.|.::...||                                 .:|||
pombe   995 VNNFVDIGVSVAPKDLYGYPLYDTEVVSLAFNKEDASSMKGLCCFAKVERIVRQTNGVLVVLRTL 1059

  Fly   604 ---QLNNKL-------------ISTNPEQMQAVRQIAL--------------------------- 625
               ::.|||             ::|...|...:|.:..
pombe  1060 PSMEILNKLQGNCALWFLKLTNLATFTRQYAGIRGLPYFHLADDIIRARPCSQPVKHSSSEIKAA 1124

  Fly   626 -------SPRLKAPY---------IVFGPPGTGKTSTIVEAIYQL-------YINRP-------- 659
                   .|:.||..         ::.||||||||.||:..|..|       :|.||
pombe  1125 MKRYQVNEPQAKAIMCALDNNGFTLIQGPPGTGKTKTIIGIISALLVDLSRYHITRPNQQSKSTE 1189

  Fly   660 -ETHILVLAGSNTACDEVALRLLRA--IAKAPQSQPRPLTRIFSANCDRRIDNIDDLLLEYS--- 718
             :..||:.|.||.|.|||.|||.|.  :....:..|| :.||  .|.:....::.||.|||.
pombe  1190 SKQQILLCAPSNAAVDEVLLRLKRGFLLENGEKYIPR-VVRI--GNPETINVSVRDLSLEYQTEK 1251

  Fly   719 -----NMYTVH-------------FYPAVQAVH-------------------------------- 733
                 |...:.             ||..:|.:.
pombe  1252 QLLEVNQGAIDLGSLQELTRWRDTFYDCIQKIEELEKQIDVARDVAEDTKSLGKELQNKINEKNL 1316

  Fly   734 --------------------------------QYRIVICTLSLAGKLSTGGFAANNVYTHVFVDE 766
                                            |..:|..|||.:|.......:.|  ::.|.:||
pombe  1317 AEQKVEELQSQSFTKNKEVDLLRKKAQKAILKQADVVCATLSGSGHDLVAHSSLN--FSTVIIDE 1379

  Fly   767 AAASTEAEVLMGI-----TCTLSPTLNLILSGDHKQLGPVLQSQRANEWGLGLTLFERLLQRKCY 826
            ||.:.|.:.::.:     .|        ||.||..||.|.:.|::|.......:||.|:.:
pombe  1380 AAQAVELDTIIPLRYGAKKC--------ILVGDPNQLPPTVLSKKAASLNYSQSLFVRIQK---- 1432

  Fly   827 QVEEDGSYNASVQTRLIR-NFRSHPEIVSLYNNMYYEGHLR-----TEAPMEIVCRFHNWFYLPN 885
                    |.|.|..|:. .:|.||:|....:..:|:..|.     .|...::      |...|.
pombe  1433 --------NFSNQMCLLSIQYRMHPDISHFPSKKFYDSRLEDGDNMAEKTQQV------WHVNPK 1483

  Fly   886 ATFPIMFHSVFG--TTMNTKSSVSLCNNKEIDVVMDYVKDLMY----FGLNGEKLLQTDIGIISP 944
            .|...:| .|.|  .|.||.|:.:|   :|::.:::.|.:|:.    ....|.      ||:|:|
pombe  1484 FTQYRLF-DVRGKERTSNTMSTYNL---EEVEYLVNMVDELLNKFPDVNFTGR------IGVITP 1538

  Fly   945 YKNQYQRIQEQLNMRN----WSQIDCGSVELFQGKEKHVIIVSFVRSFTPK-LGFLNNERRLNVL 1004
            |::|...::....::.    .|.||..:|:.|||:||.:|..|.|:|::.. :|||.:.|||||.
pombe  1539 YRSQLHELRRAFKVKYGKSFMSTIDIQTVDGFQGQEKDIIFFSCVKSYSKHGIGFLRDFRRLNVA 1603

  Fly  1005 LSRPISLLILIGNPRTLSQNSDFQHIIEMCRNRKTLVGEQYL------------------NEDFI 1051
            |:|..|.|::|||..||..:..:..:::...:|| ||...::                  ||:|:
pombe  1604 LTRARSSLLIIGNMETLKTDDLWGSLVDDALSRK-LVESPHIDSEGRLITISRTSEKRMKNEEFV 1667

  Fly  1052 --TNKKTGANNVNKGGAAGDQPASGLRQ 1077
              .:||          .|..:|:..:||
pombe  1668 EPPSKK----------LANSEPSKEIRQ 1685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6701	NP_001188923.1	TIGR00376	424..1037	CDD:273041	182/870 (21%)
		AAA_19	618..687	CDD:289986	32/129 (25%)
		AAA_12	812..1019	CDD:289832	63/223 (28%)
sen1	NP_594119.1	SEN1_N	53..693	CDD:289496	47/225 (21%)
		DNA2	765..1641	CDD:224037	199/956 (21%)
		AAA_19	1137..1212	CDD:289986	27/74 (36%)
		P-loop_NTPase	<1350..>1410	CDD:304359	19/69 (28%)
		AAA_12	1422..1618	CDD:289832	63/223 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810