DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6701 and SETX

DIOPT Version :9

Sequence 1:	NP_001188923.1	Gene:	CG6701 / 36550	FlyBaseID:	FBgn0033889	Length:	1333	Species:	Drosophila melanogaster
Sequence 2:	NP_001338457.1	Gene:	SETX / 23064	HGNCID:	445	Length:	2706	Species:	Homo sapiens

Alignment Length:	866	Identity:	191/866 - (22%)
Similarity:	324/866 - (37%)	Gaps:	265/866 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   598 LASGVLQLN------NKLIST------------NPEQMQAVR----QIALSPRLKAPYIVFGPPG 640
            ||..||..|      ..|::|            |.:|.:|:.    .:..||.:....::.||||
Human  1902 LARAVLNPNPMDFCTKDLLTTTSERIIAYLRDFNEDQKKAIETAYAMVKHSPSVAKICLIHGPPG 1966

  Fly   641 TGKTSTIVEAIYQLYI-NRPETH-------------ILVLAGSNTACDEVALRLLRAIAKAPQSQ 691
            |||:.|||..:|:|.. |:.:.|             :||.|.||.|.||:..:::....:..:.:
Human  1967 TGKSKTIVGLLYRLLTENQRKGHSDENSNAKIKQNRVLVCAPSNAAVDELMKKIILEFKEKCKDK 2031

  Fly   692 PRPLTRIFSANC-DRRI------DNIDDLLLEYS-----NMYTVHFYPA-VQAVHQYR------- 736
            ..||     .|| |..:      .:|:..:|::|     |.......|: |||:|:.:
Human  2032 KNPL-----GNCGDINLVRLGPEKSINSEVLKFSLDSQVNHRMKKELPSHVQAMHKRKEFLDYQL 2091

  Fly   737 ----------------------------------------------------------IVICTLS 743
                                                                      |:.||||
Human  2092 DELSRQRALCRGGREIQRQELDENISKVSKERQELASKIKEVQGRPQKTQSIIILESHIICCTLS 2156

  Fly   744 LAGKL-------STGGFAANNVYTHVFVDEAAASTEAEVLMGITCTLSPTLN----LILSGDHKQ 797
            .:|.|       ..||..    ::.|.||||..|.|.|       ||:|.::    |||.||.||
Human  2157 TSGGLLLESAFRGQGGVP----FSCVIVDEAGQSCEIE-------TLTPLIHRCNKLILVGDPKQ 2210

  Fly   798 LGPVLQSQRANEWGLGLTLFERLLQRKCYQVEEDGSYNASVQTRLIR---NFRSHPEIVSLYNNM 859
            |.|.:.|.:|.|:|..    :.::.|.|..:||:..:|...:..:::   .:|.||:|....:|.
Human  2211 LPPTVISMKAQEYGYD----QSMMARFCRLLEENVEHNMISRLPILQLTVQYRMHPDICLFPSNY 2271

  Fly   860 YYEGHLRTEAPMEIVCRFHNWFYLPNATFPIMFHSVFGTTMNTKSSVSLCNNKEIDVVMDYV--- 921
            .|..:|:|....|.:....:|.:.|...|.:      |.....:.:.|..|.:||.:||:.:
Human  2272 VYNRNLKTNRQTEAIRCSSDWPFQPYLVFDV------GDGSERRDNDSYINVQEIKLVMEIIKLI 2330

  Fly   922 ----KDLMYFGLNGEKLLQTDIGIISPYKNQYQRIQEQL----NMRNWSQIDCGSVELFQGKEKH 978
                ||:.:          .:||||:.||.|...||:.|    :.:..:::|  :|:.|||::|.
Human  2331 KDKRKDVSF----------RNIGIITHYKAQKTMIQKDLDKEFDRKGPAEVD--TVDAFQGRQKD 2383

  Fly   979 VIIVSFVR--SFTPKLGFLNNERRLNVLLSRPISLLILIGNPRTLSQ------------------ 1023
            .:||:.||  |....:|||.:.:||||.::|....|.::|:.|||.|
Human  2384 CVIVTCVRANSIQGSIGFLASLQRLNVTITRAKYSLFILGHLRTLMQLLPRSFCVHVNHSPFFSP 2448

  Fly  1024 -----------NSDFQHIIEMCRNRKTLV---GEQYLNEDF------------ITNKKTGANNVN 1062
                       |..:..:|:..:.|..::   .:.|.::..            :|:..|.|
Human  2449 EPKYLHWALKENQHWNQLIQDAQKRGAIIKTCDKNYRHDAVKILKLKPVLQRSLTHPPTIA---- 2509

  Fly  1063 KGGAAGDQPASGLRQPLKRKNHAKNPVQDAKIFYSKNELLNLGNECQRKKSELETIFDELPKVPR 1127
               ..|.:|..||.........||..|. |.::::.::...:......|..|...:.|:| :.||
Human  2510 ---PEGSRPQGGLPSSKLDSGFAKTSVA-ASLYHTPSDSKEITLTVTSKDPERPPVHDQL-QDPR 2569

  Fly  1128 SVDHDLDEVRSIEAQLKDFQLETKQDAAGTSILVTNAPVTNAAAPSVIPRAGLMKQETPALHS-- 1190
                          .||...:|.|     ..|.:.:...::...|...|..|  :...|.:|.
Human  2570 --------------LLKRMGIEVK-----GGIFLWDPQPSSPQHPGATPPTG--EPGFPVVHQDL 2613

  Fly  1191 SSVSRPAIRKPTVSAATPVAKSRSPMPEIPSSSKHPISMSSNPLSTNTERCVNGVLCGIEAVPPS 1255
            |.:.:||.....:|:..|..:.     |.|::|....:..|.......|.|...     ||...|
Human  2614 SHIQQPAAVVAALSSHKPPVRG-----EPPAASPEASTCQSKCDDPEEELCHRR-----EARAFS 2668

  Fly  1256 ENKTTRSSAYNHIPSGNFRFE 1276
            |.:..:..:..|....|.|::
Human  2669 EGEQEKCGSETHHTRRNSRWD 2689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6701	NP_001188923.1	TIGR00376	424..1037	CDD:273041	144/608 (24%)
		AAA_19	618..687	CDD:289986	25/86 (29%)
		AAA_12	812..1019	CDD:289832	57/222 (26%)
SETX	NP_001338457.1	SEN1_N	37..>351	CDD:315409
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1158..1219
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1237..1258
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1351..1385
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1579..1604
		AAA_11	1933..2218	CDD:315699	70/300 (23%)
		Bipartite nuclear localization signal. /evidence=ECO:0000255	2070..2087		5/16 (31%)
		AAA_12	2225..2424	CDD:315700	56/220 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2503..2525		7/28 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2585..2606		3/22 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2626..2706		15/74 (20%)
		Necessary for nuclear localization	2690..2706		191/866 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141442
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148890at33208
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750