DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6701 and Ighmbp2

DIOPT Version :9

Sequence 1:	NP_001188923.1	Gene:	CG6701 / 36550	FlyBaseID:	FBgn0033889	Length:	1333	Species:	Drosophila melanogaster
Sequence 2:	NP_033238.2	Gene:	Ighmbp2 / 20589	MGIID:	99954	Length:	993	Species:	Mus musculus

Alignment Length:	913	Identity:	199/913 - (21%)
Similarity:	349/913 - (38%)	Gaps:	210/913 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   405 ERGREITQENLTGTLRTLLQVEDIERLQH----YLSLKQSEMELHQFGRELSV--KMQMGTTSMS 463
            ||..|:.:.      |:..:...:..||.    .|.|:.|......:|:.|..  ..:.|...:.
Mouse    20 ERDAEVEER------RSWQEHSSLRELQSRGVCLLKLQVSSQRTGLYGQRLVTFEPRKFGPAVVL 78

  Fly   464 VEDILSPGDDVLIINEKGNPKSAVRKMLENNNNVLELALKDFDSILRWARNVDGMVGSLDKQPRV 528
            ..:..:.||.|.:.:...|.:.|...:.......:.:|   ||.......|:|        :...
Mouse    79 PSNSFTSGDIVGLYDTNENSQLATGVLTRITQKSVTVA---FDESHDLQLNLD--------RENT 132

  Fly   529 YFARILGVSTQRVNITCERQLPDNTTYTLIFRPLRAVMRYQYRALQQLSFTRH----SDVQRILF 589
            |  |:|             :|.::.||..:.:.|..:.:|            |    |.:..||.
Mouse   133 Y--RLL-------------KLANDVTYKRLKKALMTLKKY------------HSGPASSLIDILL 170

  Fly   590 PGEIPNTPLASGVLQLNNKLISTNPEQMQAVRQIALSPRLKAPYIVFGPPGTGKTSTIVEAIYQL 654
            ....|:..:....|...|..:..:  |.:|| ..||:.:..|  |:.||||||||:|:||.|.|.
Mouse   171 GSSTPSPAMEIPPLSFYNTTLDLS--QKEAV-SFALAQKELA--IIHGPPGTGKTTTVVEIILQA 230

  Fly   655 YINRPETHILVLAGSNTACDEVALRL-------LR------------------AIAKAPQSQ--- 691
            .  :....:|..|.||.|.|.:..||       ||                  .:|::..:|
Mouse   231 V--KQGLKVLCCAPSNIAVDNLVERLALCKKRILRLGHPARLLESVQHHSLDAVLARSDNAQIVA 293

  Fly   692 --PRPLTRIFSAN---CDRRIDN--IDDLLLEYSNMYTVHFYPAVQAVHQYRIVICTLSLAGKLS 749
              .|.:.::|..|   .|:|...  ..::.|....:........||::....:|:.|.:.|....
Mouse   294 DIRRDIDQVFGKNKKTQDKREKGNFRSEIKLLRKELKEREEAAIVQSLTAADVVLATNTGASSDG 358

  Fly   750 TGGFAANNVYTHVFVDEAAASTEAEVLMGITCTLSPTL---NLILSGDHKQLGPVLQSQRANEWG 811
            .......:.:..|.|||.|.:.||      :|.: |.|   ..||:|||:||.|...|.||...|
Mouse   359 PLKLLPEDYFDVVVVDECAQALEA------SCWI-PLLKAPKCILAGDHRQLPPTTVSHRAALAG 416

  Fly   812 LGLTLFERLLQRKCYQVEEDGSYNASVQTRLIRNFRSHPEIVSLYNNMYYEGHLRTEAPMEIVCR 876
            |..:|.|||.::          :.|.|...|...:|.|..|:...:...|.|.|.:...:    .
Mouse   417 LSRSLMERLAEK----------HGAGVVRMLTVQYRMHQAIMCWASEAMYHGQLTSHPSV----A 467

  Fly   877 FHNWFYLPNAT------FPIMFHSVFG---TTMNTKSSVSLCNNKEIDVVMDYVKDLMYFGLNGE 932
            .|....||..|      .|::.....|   ..:..:.|.|..|..|:.:|..:::.|:..|:..
Mouse   468 GHLLKDLPGVTDTEETRVPLLLIDTAGCGLLELEEEDSQSKGNPGEVRLVTLHIQALVDAGVQA- 531

  Fly   933 KLLQTDIGIISPYKNQYQRIQEQLNMRNWSQIDCGSVELFQGKEKHVIIVSFVRSFTP-KLGFLN 996
                .||.:|:||..|...:::.|:.:: .:::..||:.|||:||..::::||||... ::|||.
Mouse   532 ----GDIAVIAPYNLQVDLLRQSLSNKH-PELEIKSVDGFQGREKEAVLLTFVRSNRKGEVGFLA 591

  Fly   997 NERRLNVLLSRPISLLILIGNPRTLSQNSDFQHIIE-MCRNRKTLVGEQYLN----EDFITNKKT 1056
            .:||:||.::|....:.:|.:..|::.::..:.::: ...:.:.....:||:    |::......
Mouse   592 EDRRINVAVTRARRHVAVICDSHTVNNHAFLKTLVDYFTEHGEVRTAFEYLDDIVPENYTHEGSQ 656

  Fly  1057 GANNVNKGGAAGDQPASGLRQPL----------------KRKNHAKNPVQDAKIFYSKNELLNLG 1105
            |.:.|.|...    |::.:|:|.                :||...|.|....:..:|.:     .
Mouse   657 GHSRVPKPKC----PSTSIRKPASDQESGQETRAAPRHGRRKPSEKPPGSHVQSQHSSS-----A 712

  Fly  1106 NECQR--------------------KKSELETIFDELPKVPRSV-DHDLDEVRSIEAQLKDFQLE 1149
            |...|                    |:|:||        .|.|: .||...|..:   .::|.|.
Mouse   713 NGSDRTGGPDRTEHFRATIEEFVASKESQLE--------FPTSLSSHDRLRVHQL---AEEFGLR 766

  Fly  1150 TKQDAAGTSILVTNAPVTNAAAPSVIPRAGLMKQETPALHSSSVSRPAIRKPTVSAATPVAKSRS 1214
            ......|.:..:|.:..:.|::.||.|:            .||...||..:|...|..||...::
Mouse   767 HDSTGEGKARHITVSRRSPASSGSVAPQ------------PSSPPSPAQAEPEPRAEEPVTVVQA 819

  Fly  1215 PMP 1217
            ..|
Mouse   820 HCP 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6701	NP_001188923.1	TIGR00376	424..1037	CDD:273041	153/671 (23%)
		AAA_19	618..687	CDD:289986	30/93 (32%)
		AAA_12	812..1019	CDD:289832	54/216 (25%)
Ighmbp2	NP_033238.2	TIGR00376	19..640	CDD:273041	157/697 (23%)
		AAA_19	197..255	CDD:289986	26/62 (42%)
		AAA_12	417..613	CDD:289832	54/215 (25%)
		SS DNA-binding. /evidence=ECO:0000250	637..783		29/165 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	650..723		13/81 (16%)
		R3H_Smubp-2_like	724..782	CDD:100070	13/68 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	765..815		14/61 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	837..872
		Nuclear localization signal. /evidence=ECO:0000255	862..866
		ZnF_AN1	895..935	CDD:197545
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	953..993
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810