DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6701 and Upf1

DIOPT Version :9

Sequence 1:	NP_001188923.1	Gene:	CG6701 / 36550	FlyBaseID:	FBgn0033889	Length:	1333	Species:	Drosophila melanogaster
Sequence 2:	NP_001116301.1	Gene:	Upf1 / 19704	MGIID:	107995	Length:	1124	Species:	Mus musculus

Alignment Length:	1268	Identity:	276/1268 - (21%)
Similarity:	471/1268 - (37%)	Gaps:	379/1268 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 GATNIGSLLHRTNFLI----NTPRGNPNYRIKNFSLMDFRKEKFNLLDEQHRLRGIASTTDVPGG 168
            ||...||....|:|.:    .||.|.|.                          |...    |||
Mouse    25 GADTQGSEFEFTDFTLPSQTQTPPGGPG--------------------------GAGG----PGG 59

  Fly   169 APAEGNKPIIEEYKLDTDVKPTLLKFQKRLLLQSDKDFELQSLGCYICQENFEKIEKYEEHVEYH 233
            |.|.|     ...:||..|.|      :.:|.....|..:......:.:.|||:
Mouse    60 AGAGG-----AAGQLDAQVGP------EGILQNGAVDDSVAKTSQLLAELNFEE----------- 102

  Fly   234 GDESDFQSLKKMKKYPTPIVSLSY-----QTCV------------------DSHYFGFTLKTFRK 275
             ||.|....|.:     |:.:.||     ..||                  .||.....::...|
Mouse   103 -DEEDTYYTKDL-----PVHACSYCGIHDPACVVYCNTSKKWFCNGRGNTSGSHIVNHLVRAKCK 161

  Fly   276 DLVVDKFIIVQLRQFYYVYGAQMPLPVNGSGELVF--------------FV----DSHVFMILRE 322
            ::.:.|               ..||     ||.|.              |:    ||.|.::.|
Mouse   162 EVTLHK---------------DGPL-----GETVLECYNCGCRNVFLLGFIPAKADSVVVLLCR- 205

  Fly   323 QPIVIGFTI--------QGEKYVEQHHFMR-TEALPKASFNINPYRLSSKETFKSKGLPPANPPI 378
            ||.....::        |.:..::...|:. ...:|.....:...::::::..|.:.|...||..
Mouse   206 QPCASQSSLKDINWDSSQWQPLIQDRCFLSWLVKIPSEQEQLRARQITAQQINKLEELWKENPSA 270

  Fly   379 QVLSALK---HEDAQMCLASFDNQYQNYCERGREITQENLTGTLRTLLQVE-DIERLQHYLSLKQ 439
            .:....|   .|:.|..|..:::.||          .:|:.|   .|:::| |.::     .||:
Mouse   271 TLEDLEKPGVDEEPQHVLLRYEDAYQ----------YQNIFG---PLVKLEADYDK-----KLKE 317

  Fly   440 SEMELHQFGRELSVKMQMGTTSMSVEDILSPGDDVLIINEKGNPKSAVRKMLENNNNVLELALKD 504
            |:.:     ..::|:..:|.....:.....|..|                  ..|.:::.:.|:|
Mouse   318 SQTQ-----DNITVRWDLGLNKKRIAFFTLPKTD------------------SGNEDLVIIWLRD 359

  Fly   505 F-----DSI-LRWARNVDGM---VGSLDKQPRVYFARI-------LGVSTQRVNITCERQLP--- 550
            .     |.| ||:..::..:   :|.:.|.|..|...|       :|..   |.:|...|:.
Mouse   360 MRLMQGDEICLRYKGDLAPLWKGIGHVIKVPDNYGDEIAIELRSSVGAP---VEVTHNFQVDFVW 421

  Fly   551 DNTTYTLIFRPLR-------AVMRYQYRALQQLSFTRHSDVQRILFPGEIPNTPLASGVLQLNNK 608
            .:|::..:...|:       :|..|.|..|     ..| :|:.::...::|....|.|:..||:
Mouse   422 KSTSFDRMQSALKTFAVDETSVSGYIYHKL-----LGH-EVEDVVIKCQLPKRFTAQGLPDLNH- 479

  Fly   609 LISTNPEQMQAVRQIALSPRLKAPY-IVFGPPGTGKTSTIVEAIYQL--YINRPETHILVLAGSN 670
                  .|:.||:.:     |:.|. ::.||||||||.|....:|.|  ..|.|   :||.|.||
Mouse   480 ------SQVYAVKTV-----LQRPLSLIQGPPGTGKTVTSATIVYHLARQGNGP---VLVCAPSN 530

  Fly   671 TACDEV-------ALRLLRAIAKAPQSQPRPLTRIFSANCDRRIDNIDDLLLEYSNMYTVHFYPA 728
            .|.|::       .|:::|..||:.::...|::.:...|   :|.|:|.:             |.
Mouse   531 IAVDQLTEKIHQTGLKVVRLCAKSREAIDSPVSFLALHN---QIRNMDSM-------------PE 579

  Fly   729 VQAVHQ---------------YR---------------IVICTLSLAG--KLSTGGFAANNVYTH 761
            :|.:.|               ||               ::.||...||  :|      |...:..
Mouse   580 LQKLQQLKDETGELSSADEKRYRALKRTAERELLMNADVICCTCVGAGDPRL------AKMQFRS 638

  Fly   762 VFVDEAAASTEAEVLMGITCTLSPTLNLILSGDHKQLGPVLQSQRANEWGLGLTLFERLLQRKCY 826
            :.:||:..:||.|.::.:.....   .|||.|||.|||||:..::|.:.||..:|||||:.....
Mouse   639 ILIDESTQATEPECMVPVVLGAK---QLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVVLGIR 700

  Fly   827 QVEEDGSYNASVQTRLIRNFRSHPEIVSLYNNMYYEGHLR--TEAPMEIVCRFHNWFYLPNATFP 889
            .:            ||...:|.||.:.:..:|::|||.|:  ..|...:...|.  |..|....|
Mouse   701 PI------------RLQVQYRMHPALSAFPSNIFYEGSLQNGVTAADRVKKGFD--FQWPQPDKP 751

  Fly   890 IMFHSVFGTTMNTKSSVSLCNNKEIDVVMDYVKDLMYFGLNGEKLLQTDIGIISPYKN------Q 948
            :.|:...|......|..|..|..|...|......|:..|...::     ||||:||:.      |
Mouse   752 MFFYVTQGQEEIASSGTSYLNRTEAANVEKITTKLLKAGAKPDQ-----IGIITPYEGQRSYLVQ 811

  Fly   949 YQRIQEQLNMRNWSQIDCGSVELFQGKEKHVIIVSFVRSFTPK-LGFLNNERRLNVLLSRPISLL 1012
            |.:....|:.:.:.:::..||:.|||:||..||:|.||:...: :||||:.|||||.|:|....:
Mouse   812 YMQFSGSLHTKLYQEVEIASVDAFQGREKDFIILSCVRANEHQGIGFLNDPRRLNVALTRARYGV 876

  Fly  1013 ILIGNPRTLSQNSDFQHIIEMCRNRKTLVGEQYLNEDFITNKKTGANNVNKGGAAGDQPASGLRQ 1077
            |::|||:.||:...:.|::...:.:|.||                           :.|.:.||:
Mouse   877 IIVGNPKALSKQPLWNHLLSYYKEQKALV---------------------------EGPLNNLRE 914

  Fly  1078 PLKRKNHAKNPVQDAKIFYSKNELLNLGNECQRKKSELETIFDELPK-VPRSVDHDLDEVRSIEA 1141
            .|.:             |....:|:|..|...|..:  ..::|.... :|.|| :|    ||.:.
Mouse   915 SLMQ-------------FSKPRKLVNTVNPGARFMT--TAMYDAREAIIPGSV-YD----RSSQG 959

  Fly  1142 QLKDFQLETKQDAAGTSILVTNAPVTNAAAPSVIPRAGLMKQETPALHSSSVSRPAIRKPTVSAA 1206
            :..:...:|....:    :::..|...||....||...:|....|..:....:.||..:.|....
Mouse   960 RPSNMYFQTHDQIS----MISAGPSHVAAMNIPIPFNLVMPPMPPPGYFGQANGPAAGRGTPKTK 1020

  Fly  1207 TPVA---KSRSPMPEIPSSSKHPISMSSNPLST 1236
            |...   |:|..:|. ||.:..|.|.:|..:::
Mouse  1021 TGRGGRQKNRFGLPG-PSQTTLPNSQASQDVAS 1052

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6701	NP_001188923.1	TIGR00376	424..1037	CDD:273041	170/690 (25%)
		AAA_19	618..687	CDD:289986	27/78 (35%)
		AAA_12	812..1019	CDD:289832	65/215 (30%)
Upf1	NP_001116301.1	Sufficient for interaction with RENT2. /evidence=ECO:0000250	1..410		89/507 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..69		11/64 (17%)
		DNA2	140..915	CDD:224037	208/931 (22%)
		DEXXQc_UPF1	476..709	CDD:350797	73/284 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1004..1053		12/50 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1066..1091
		[ST]-Q motif 1	1084..1085
		[ST]-Q motif 2	1102..1103
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1105..1124
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810