Protein Alignment CG6701 and DNA2

DIOPT Version :9

• Sequence 1: NP_001188923.1
• Gene: CG6701 / 36550
• FlyBaseID: FBgn0033889
• Length: 1333
• Species: Drosophila melanogaster
• Sequence 2: XP_006717743.1
• Gene: DNA2 / 1763
• HGNCID: 2939
• Length: 1090
• Species: Homo sapiens
• Alignment Length: 1084
• Identity: 223/1084 - (20%)
• Similarity: 399/1084 - (36%)
• Gaps: 333/1084 - (30%)

  Fly    86 LFEVHLNALPNSSEIRQKLSSQGATNIGSLLHRTNFLINTPRGNPNYRIKNFSLMDFRKEKFNLL 150
            |.||...|: |:|...:||.......|..:.|....          ||: |.|..:.::|..:.|
Human   192 LHEVFQKAI-NNSFAPEKLQELAFQTIQEIRHLKEM----------YRL-NLSQDEIKQEVEDYL 244

  Fly   151 --------DEQHRLRGIASTTDVPGGAPAEGNKPIIEEYKLDTDVKPTLLKFQKRLLLQSDKDFE 207
                    |..|:    .::||.|                            |.:|.|.||...:
Human   245 PSFCKWAGDFMHK----NTSTDFP----------------------------QMQLSLPSDNSKD 277

  Fly   208 LQSLGCYICQENFEKIEKYEEHV-----EYHGDESDFQSLKKMKKYPT--PIVSLSYQTCVDSHY 265
            ..:     |.....|....||.:     ...|.......:|..:.|.|  .|:.|..:|..:|:.
Human   278 NST-----CNIEVVKPMDIEESIWSPRFGLKGKIDVTVGVKIHRGYKTKYKIMPLELKTGKESNS 337

  Fly   266 FGFTLKTFRKDLVVDKFIIVQLRQ-------FYYVYGAQMPLPVNGSGELVFFVDSHVFMILREQ 323
            .     ..|..:|:...:..:.|.       .|...|...|:|.|       .:|....:.||.|
Human   338 I-----EHRSQVVLYTLLSQERRADPEAGLLLYLKTGQMYPVPAN-------HLDKRELLKLRNQ 390

  Fly   324 PIVIGFTIQGEKYVEQHHFMRTEALPKASFNINPYRLSSKETFK---------------SKGLPP 373
               :.|::       .|...::....|......|..:..::|.|               .:.:..
Human   391 ---MAFSL-------FHRISKSATRQKTQLASLPQIIEEEKTCKYCSQIGNCALYSRAVEQQMDC 445

  Fly   374 ANPPIQVLSALKHEDAQM-----------CL------ASFDNQ--YQNYCERGREITQENLTGTL 419
            ::.||.:|..::.|...:           ||      .|.||:  :||.
Human   446 SSVPIVMLPKIEEETQHLKQTHLEYFSLWCLMLTLESQSKDNKKNHQNI---------------- 494

  Fly   420 RTLLQVEDIE----------RLQHYLSLKQSEMELHQFGRELSVKMQMGTTSMSVEDILSPGDDV 474
             .|:...::|          |::| :.:......||.|        |....::.|.:::: ||.|
Human   495 -WLMPASEMEKSGSCIGNLIRMEH-VKIVCDGQYLHNF--------QCKHGAIPVTNLMA-GDRV 548

  Fly   475 LIINE--------KGNPK----SAVRKMLENNNNVL-ELALKDFDSILRWARN--VDGMVGSLDK 524
            ::..|        :|..|    :.|..:|:.|.:|| |..|...|   :..:|  :|..:|:|.|
Human   549 IVSGEERSLFALSRGYVKEINMTTVTCLLDRNLSVLPESTLFRLD---QEEKNCDIDTPLGNLSK 610

  Fly   525 QPRVYFARILGVSTQRVNITCERQLPDNTTYTLIFRPLRAVMRYQYRALQQLSFTRHSDVQRILF 589
                                    |.:|   |.:.:.||.:: ..:|..|.:|:
Human   611 ------------------------LMEN---TFVSKKLRDLI-IDFREPQFISY----------- 636

  Fly   590 PGEIPNTPLASGVLQLNNK------LISTNPEQMQAVRQIALSPRLKAPYIVFGPPGTGKTSTIV 648
                     .|.||..:.|      |...|..|.||::::.||   |...::.|.||||||:||.
Human   637 ---------LSSVLPHDAKDTVACILKGLNKPQRQAMKKVLLS---KDYTLIVGMPGTGKTTTIC 689

  Fly   649 EAIYQLYINRPETHILVLAGSNTACDEVALRLLR---AIAKAPQSQP-RPLTRIFSANCDRRIDN 709
            ..:..||  .....:|:.:.:::|.|.:.|:|.:   ...:..|.|. .|..:.|:.....|..:
Human   690 TLVRILY--ACGFSVLLTSYTHSAVDNILLKLAKFKIGFLRLGQIQKVHPAIQQFTEQEICRSKS 752

  Fly   710 IDDLLLEYSNMYTVHFYPAVQAVHQYRIVICTLSLAGKLSTGGFAANNVYTHVFVDEAAASTEAE 774
            |..|.|             ::.::..::::.|..:.   ......:..::....||||:..:: .
Human   753 IKSLAL-------------LEELYNSQLIVATTCMG---INHPIFSRKIFDFCIVDEASQISQ-P 800

  Fly   775 VLMGITCTLSPTLNLILSGDHKQLGPVLQSQRANEWGLGLTLFERLLQRKCYQVEEDGSYNASVQ 839
            :.:|   .|..:...:|.|||:||.|::.::.|...|:..:||:||.|            |.|..
Human   801 ICLG---PLFFSRRFVLVGDHQQLPPLVLNREARALGMSESLFKRLEQ------------NKSAV 850

  Fly   840 TRLIRNFRSHPEIVSLYNNMYYEG--------------HLRTEAPMEIVCRFH------NWF--- 881
            .:|...:|.:.:|:||.|.:.|||              :||....:::...|:      .|.
Human   851 VQLTVQYRMNSKIMSLSNKLTYEGKLECGSDKVANAVINLRHFKDVKLELEFYADYSDNPWLMGV 915

  Fly   882 YLPNATFPIMFHSVFGTTMNT----------KSSVSLCNNKEIDVVMDYVKDLMYFGLNGEKLLQ 936
            :.||.  |:.|       :||          |..||  |..|..:::......:..|.:     .
Human   916 FEPNN--PVCF-------LNTDKVPAPEQVEKGGVS--NVTEAKLIVFLTSIFVKAGCS-----P 964

  Fly   937 TDIGIISPYKNQYQRIQEQLNMRNWSQIDCGSVELFQGKEKHVIIVSFVRSFTPKLG----FLNN 997
            :|||||:||:.|.:.|.:.| .|:...::..:|:.:||::|.:::||||||  .|.|    .|.:
Human   965 SDIGIIAPYRQQLKIINDLL-ARSIGMVEVNTVDKYQGRDKSIVLVSFVRS--NKDGTVGELLKD 1026

  Fly   998 ERRLNVLLSRPISLLILIGNPRTLSQNSDFQHIIEMCRNRKTLV 1041
            .|||||.::|....|||:|...:|:.....:.::....:.|.::
Human  1027 WRRLNVAITRAKHKLILLGCVPSLNCYPPLEKLLNHLNSEKLII 1070

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6701	NP_001188923.1	TIGR00376	424..1037	CDD:273041	154/684 (23%)
		AAA_19	618..687	CDD:289986	21/71 (30%)
		AAA_12	812..1019	CDD:289832	66/243 (27%)
DNA2	XP_006717743.1	Dna2	101..312	CDD:285859	31/168 (18%)
		Cas4_I-A_I-B_I-C_I-D_II-B	<291..427	CDD:294426	28/157 (18%)
		TIGR00376	501..1062	CDD:273041	154/677 (23%)
		P-loop_NTPase	655..905	CDD:304359	66/286 (23%)
		AAA_12	835..1047	CDD:289832	66/242 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141447
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740