DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6701 and dna-2

DIOPT Version :9

Sequence 1:	NP_001188923.1	Gene:	CG6701 / 36550	FlyBaseID:	FBgn0033889	Length:	1333	Species:	Drosophila melanogaster
Sequence 2:	NP_496516.1	Gene:	dna-2 / 174809	WormBaseID:	WBGene00001016	Length:	1069	Species:	Caenorhabditis elegans

Alignment Length:	708	Identity:	159/708 - (22%)
Similarity:	276/708 - (38%)	Gaps:	205/708 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   404 CERGREITQENLTGTLRTLLQVEDIERLQHYLSLKQSEMELHQFGRELSVKMQMGTTSMSVEDIL 468
            |||.| :|.:|....|:::.     ||::....|.    :||....|:| ..|....|.|.:.:.
Worm   479 CERER-MTSQNKDLWLKSVQ-----ERVEEGTCLS----DLHPVSEEMS-NSQKIIISFSRKFLK 532

  Fly   469 S-------PGDDVLIINEKGNPKSAVRKMLENNNNVLELALKDFDSILRWARNVDGMVGSLDKQP 526
            |       |||..|:.|:|              :..:..||.|..|               |.|
Worm   533 SSNTPTFRPGDVCLLSNKK--------------HIAIGFALIDEVS---------------DDQ- 567

  Fly   527 RVYFARILGVSTQRVNITCERQLPDNTTYTLIFRPLRAVMRYQYRALQQL----SFTRHS----D 583
                 :|:.:||.:                        .::.:|.|...|    |.:.||    :
Worm   568 -----QIVKISTDK------------------------TIKSRYEAPFHLDKYTSMSTHSTTLGN 603

  Fly   584 VQRILFPGEIPNTPLASGVLQLNNKLISTNPEQMQAVRQIALSPRLKAPYI-------------- 634
            :..:|...||..        :|.|.|:...|..:.......|:|.:|...|
Worm   604 LVYLLQNDEIGK--------RLRNILVDLLPPIIMDATGFNLTPAIKKIIIKAKLNNEQRKAVVH 660

  Fly   635 ---------VFGPPGTGKTSTIVEAIYQLYINRPETHILVLAGSNTACDEVALRLLRAIAKAPQS 690
                     |.|.||:||| |::..:.|..: .....:|:.|.:::|.|.:..:|.:.:|
Worm   661 ALATEDFMMVEGLPGSGKT-TLISVLIQCLV-ATNKKVLLAAFTHSAVDNILTKLTKEVA----- 718

  Fly   691 QPRPLTRIFSANCDRRIDNIDDLLL--EYSNMYTVHFYPAVQAVHQYR-IVICTLSLAGKLSTGG 752
             ...:.|:.|::..:  |:|..:.|  :..|..:..:|.||:.|.:.. ||.||
Worm   719 -AEKILRLGSSSSIK--DDIKKMTLKAKLENETSEEYYAAVRKVMKTTPIVACT----------- 769

  Fly   753 FAANNV-------YTH---VFVDEAAASTEAEVLMGITCTLSPTLNLILSGDHKQLGPVLQSQRA 807
              .::|       |.|   |.||||:...|..:|.    .|:.:...:|.||.|||.|::.|::|
Worm   770 --CHHVPRELLFSYRHFDVVIVDEASMVLEPLLLP----VLATSNKFVLVGDCKQLTPLVVSRKA 828

  Fly   808 NEWGLGLTLFERLLQRKCYQVEEDGSYNASVQTRLIRNFRSHPEIVSLYNNMYYEGHL------- 865
            .:.|.|::..|:|.|.           :..|...|...:|.:.||..|.:.::||..|
Worm   829 KQEGAGISTMEKLQQS-----------HPGVVVSLTSQYRMNREISVLSSKLFYENRLICGNESV 882

  Fly   866 ------RTEAPMEIVCRFHNWFYLPNA-TFPIMFHSVFGTTMNTKSSV---------SLCNNKEI 914
                  ||..  .||.......::..| :..|....||..|.:|.:|.         .:||:.|.
Worm   883 SRSSLDRTGD--YIVAMDDGSDHIRKALSGDIKDSCVFLDTQSTINSKMQCEDGEGGGMCNDGEA 945

  Fly   915 DVVMDYVKDLMYFGLNGEKLLQTDIGIISPYKNQYQRIQEQLNMRNWSQIDCGSVELFQGKEKHV 979
            .::.:..:..:..|:...     :||::|.|:.|...|:..||.   .:::..:::.:||:||.|
Worm   946 KLISELCQQFVMSGVKPH-----EIGVMSAYRRQVDHIRGILNS---DELEVNTIDSYQGREKRV 1002

  Fly   980 II--VSFVRSFTPKLGFLNNERRLNVLLSRPISLLILIG---NPRTLSQNSDFQHIIE 1032
            ||  :::..:.|.|...|.:|||:||.|:|....|:::|   :..|:.....|..:||
Worm  1003 IIWSLTWTNNSTKKSELLKDERRVNVALTRARQKLVVVGCKNSAETIPVLFRFSQLIE 1060

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6701	NP_001188923.1	TIGR00376	424..1037	CDD:273041	152/688 (22%)
		AAA_19	618..687	CDD:289986	19/91 (21%)
		AAA_12	812..1019	CDD:289832	55/234 (24%)
dna-2	NP_496516.1	Dna2	122..325	CDD:285859
		Cas4_I-A_I-B_I-C_I-D_II-B	<294..430	CDD:294426
		TIGR00376	480..1062	CDD:273041	158/707 (22%)
		P-loop_NTPase	650..861	CDD:304359	57/248 (23%)
		AAA_12	834..1044	CDD:289832	55/230 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910