Protein Alignment CG6701 and smg-2

DIOPT Version :9

• Sequence 1: NP_001188923.1
• Gene: CG6701 / 36550
• FlyBaseID: FBgn0033889
• Length: 1333
• Species: Drosophila melanogaster
• Sequence 2: NP_490829.1
• Gene: smg-2 / 171696
• WormBaseID: WBGene00004880
• Length: 1069
• Species: Caenorhabditis elegans
• Alignment Length: 990
• Identity: 227/990 - (22%)
• Similarity: 397/990 - (40%)
• Gaps: 241/990 - (24%)

  Fly   340 HHFMRT---EAL-----PKASFNINPYRLSSKETFKSKGLPPANPPIQVLSALKHEDAQMCLASF 396
            ||.:|:   ||.     |.....:..||..||..| :.|..|......|:...:...|.:...:.
 Worm   130 HHMVRSQHKEAYTHKDSPCGDTQLECYRCGSKNVF-NLGFIPGKKDQVVVIICRTPCASIAFQND 193

  Fly   397 DN----QYQNYCERGREITQENLTGTLRTLLQVEDIERLQHYLSLKQSEMELHQFGRELSVKMQM 457
            ||    .:::.      |.::.|...:..:...|.:.|.:...:.:...||          ::..
 Worm   194 DNWSPEDWKSV------IAEKQLLSWIVNVPSEEQVARARKITATQAVRME----------ELWR 242

  Fly   458 GTTSMSVEDILSPG-----DDVLI-------INEKGNPKSAV-----RKMLEN------------ 493
            .....:|:|:..||     |.|.:       .::...|..|:     |::.|:
 Worm   243 DHPEATVDDLNKPGLDREPDHVQLRYVDAHHYSKVFRPLVAIEAEYDRRVKESASQAVGTVRWEQ 307

  Fly   494 ---------------NNNVLELALKDFDSILRWARNVDG----MVGSLDKQP---------RVYF 530
                           .:.|::||..| :..|:.::.|||    .:||:.|.|         .:..
 Worm   308 GLRQSVLAFFHLPQFADGVMKLAKGD-ELRLKHSQTVDGSEWTKIGSVFKIPDNHGDEVGIEIRG 371

  Fly   531 ARILGVSTQRVNITCERQLPDNTTYTLIFRPL-------RAVMRYQYRALQQLSFTRHSDVQRIL 588
            |....|...|:..|.: .:.:.||:...::.|       :|:..|.|:.|     ..| ..:.::
 Worm   372 AVDKSVMESRIMFTVD-VVWNATTFERQYKALAALLNDSKAISPYLYQKL-----LGH-PAEEMM 429

  Fly   589 FPGEIPNTPLASGVLQLNNKLISTNPEQMQAVRQIALSPRLKAPYIVFGPPGTGKTSTIVEAIYQ 653
            ...::|.....:|:.:||:       .|||||:|:...|.    .::.||||||||......:|.
 Worm   430 LKFDLPRRLSVAGLPELNS-------SQMQAVKQVLTRPL----SLIQGPPGTGKTVVSATIVYH 483

  Fly   654 LYINRPETHILVLAGSNTACDEVA-------LRLLRAIAKAPQ---------SQPRPLTRIFSAN 702
            | :.:.|.::||.:.||.|.|.:|       |:::|..|::.:         :....|..:..|.
 Worm   484 L-VQKTEGNVLVCSPSNIAVDHLAEKIHKTGLKVVRLCARSREHSETTVPYLTLQHQLKVMGGAE 547

  Fly   703 CDRRI---DNIDDLL----LEYSNMYTVHFYPAVQAVHQYRIVICTLSLA--GKLSTGGFAANNV 758
            ..:.|   |...:|.    |.|..:..|..:..:.|..   ::.||.|.|  .:||       .:
 Worm   548 LQKLIQLKDEAGELEFKDDLRYMQLKRVKEHELLAAAD---VICCTCSSAADARLS-------KI 602

  Fly   759 YTH-VFVDEAAASTEAEVLMGITCTLSPTLNLILSGDHKQLGPVLQSQRANEWGLGLTLFERLLQ 822
            .|. |.:||:..:||.|:|:.|   :.....|:|.|||.|||||:..::|...||..:|||||:.
 Worm   603 RTRTVLIDESTQATEPEILVSI---MRGVRQLVLVGDHCQLGPVVICKKAAIAGLSQSLFERLVL 664

  Fly   823 RKCYQVEEDGSYNASVQT-RLIRNFRSHPEIVSLYNNMYYEGHLR---TEAPMEIVCRFHNWFYL 883
                         ..::. ||...:|.||.:....:|::|:|.|:   ||....:.....:|
 Worm   665 -------------LGIRPFRLQVQYRMHPVLSEFPSNVFYDGSLQNGVTENDRHMTGVDWHW--- 713

  Fly   884 PNATFPIMFHSVFGTTMNTKSSVSLCNNKEIDVVMDYVKDLMYFGLNGEKLLQTDIGIISPYKNQ 948
            |....|..|....|:...:.|..|..|..|...|...|..|:..|:...:     ||:|:||:.|
 Worm   714 PKPNKPAFFWHCSGSEELSASGTSFLNRTEAANVEKLVSKLIKAGVQPHQ-----IGVITPYEGQ 773

  Fly   949 ------YQRIQEQLNMRNWSQIDCGSVELFQGKEKHVIIVSFVRS-FTPKLGFLNNERRLNVLLS 1006
                  |...|..||.:.:..::..||:.|||:||..|||:.||| ....:|||::.|||||.::
 Worm   774 RSFIVNYMHTQGTLNSKLYENVEIASVDAFQGREKDYIIVTCVRSNDILGIGFLSDPRRLNVAIT 838

  Fly  1007 RPISLLILIGNPRTLSQNSDFQHIIEMCRNRKTLVGEQYLN----------EDFITNKKTGANNV 1061
            |....|:|:||.:.|:::..:..:|...::::.|. |..:|          :..|..|...|.|.
 Worm   839 RAKYGLVLVGNAKVLARHDLWHELINHYKSKEMLY-EGPINALKPLNLALPKATIRTKNNIAGNA 902

  Fly  1062 NKGGAAGDQPASGLRQPLKRKNHAKN------PVQD--AKIFYSKNELLNLGNECQRKKSELETI 1118
            |:.|             :||..:..|      |.|.  ...:.:...||::        |:|...
 Worm   903 NRFG-------------IKRMQYTFNEYKSNDPSQPRLPPTYSNSQNLLSM--------SKLAQT 946

  Fly  1119 FDELPKVPRSVDHDLDEVRSIEAQLKDFQLETKQDAAGTSILVTNAPVTNAAAPSVIPRAGLMKQ 1183
            |::...:|.   |.:|.  ::.|..::.:...:.|        ...|...|.|...:.: |:|.|
 Worm   947 FNKNVPIPA---HMMDP--NVYAAARNQKDRRRGD--------QRRPPPQAEAAMDLSQ-GMMSQ 997

  Fly  1184 ET---PALHSSSVSR 1195
            ::   |...:||.|:
 Worm   998 QSQQYPPQGASSQSQ 1012

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6701	NP_001188923.1	TIGR00376	424..1037	CDD:273041	174/713 (24%)
		AAA_19	618..687	CDD:289986	26/75 (35%)
		AAA_12	812..1019	CDD:289832	66/217 (30%)
smg-2	NP_490829.1	UPF1_Zn_bind	93..243	CDD:286500	23/129 (18%)
		DNA2	117..874	CDD:224037	194/815 (24%)
		AAA_19	452..>509	CDD:289986	23/61 (38%)
		AAA_12	654..851	CDD:289832	66/217 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810