DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6701 and AgaP_AGAP001133

DIOPT Version :9

Sequence 1:	NP_001188923.1	Gene:	CG6701 / 36550	FlyBaseID:	FBgn0033889	Length:	1333	Species:	Drosophila melanogaster
Sequence 2:	XP_322028.4	Gene:	AgaP_AGAP001133 / 1282033	VectorBaseID:	AGAP001133	Length:	1161	Species:	Anopheles gambiae

Alignment Length:	921	Identity:	232/921 - (25%)
Similarity:	364/921 - (39%)	Gaps:	198/921 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   387 EDAQMCLASFDN-QYQN-----------YCERGREI-TQENLTGTLRTLLQVEDIERLQHYLSLK 438
            |..|:.|...|. ||||           |.|:.:|. ||||:.....|.|..:.|.    |.:|.
Mosquito   273 EPQQVQLRYVDGYQYQNTFGPLVKLEADYDEKLKESQTQENIEIRWDTGLNKKTIA----YFTLA 333

  Fly   439 QSEMELHQFGRELSVKMQMGTTSMSVEDILSPGDDVLI--INEKGNPKSA---VRKMLENNNNVL 498
            :::.::.                      |..||::.:  :.|...|.|.   |.|:.:|..:.:
Mosquito   334 KNDGDMK----------------------LMHGDELKLRYVGELHKPWSCIGHVIKVPDNYGDDV 376

  Fly   499 ELALK-----------DFDSILRWARNVDGMVGSLDKQPRVYFARILGVSTQRVNITCERQLPDN 552
            .|.||           :|.....|.                      |.|.:|:.....:...|
Mosquito   377 GLELKHNHQAPIERTSNFSVDFIWK----------------------GTSFERMQQALRKFAMD- 418

  Fly   553 TTYTLIFRPLRAVMRYQYRALQQLSFTRHSDVQRILFPGEIPNTPLASGVLQLNNKLISTNPEQM 617
                     .::|..|.|..|  |...|....:.:||...:|....|..:..||.       .|:
Mosquito   419 ---------AKSVSNYIYARL--LGNVRADGAEEVLFRLNLPKHFSAPNLPDLNR-------SQV 465

  Fly   618 QAVRQIALSPRLKAPYIVFGPPGTGKTSTIVEAIYQL-YINRPETHILVLAGSNTACDEVA---- 677
            .|||. ||...|.   ::.||||||||.|....:||| .:|  ...|||.|.||||.|::.
Mosquito   466 YAVRH-ALQRPLS---LIQGPPGTGKTVTSATIVYQLARLN--SGPILVCAPSNTAVDQLTEKIH 524

  Fly   678 ---LRLLRAIAKAPQSQPRPLTRIFSANCDRRI-------------DNIDDLLLEYSNMY-TVHF 725
               |:::|..|::.::...|::.:...|..|.:             |...:|.|.....| ::..
Mosquito   525 RTNLKVVRVCARSREAIDSPVSFLALHNQIRNMAQNSELKKLQQLKDETGELSLSDERRYRSLKK 589

  Fly   726 YPAVQAVHQYRIVICTLSLAGKLSTGGFAANNVYTHVFVDEAAASTEAEVLMGITCTLSPTLNLI 790
            ....:.:....::.||...||.|.......|:    :.:||:..|||.|.::.:.....   .||
Mosquito   590 QAERELLEAADVICCTCVGAGDLRLQRIKFNS----ILIDESMQSTEPECMVPVVLGAK---QLI 647

  Fly   791 LSGDHKQLGPVLQSQRANEWGLGLTLFERL--LQRKCYQVEEDGSYNASVQTRLIRNFRSHPEIV 853
            |.|||.|||||:..::|.:.||..:|||||  |..:.:::|        ||      :|.|||:.
Mosquito   648 LVGDHCQLGPVVMCKKAAKAGLSQSLFERLVALGIRPFRLE--------VQ------YRMHPELS 698

  Fly   854 SLYNNMYYEGHLRTEAPMEIVC----RFHNWFYLPNATFPIMFHSVFGTTMNTKSSVSLCNNKEI 914
            ...:|.:|||.|:..     ||    :....|..|:...|:.|....|......|..|..|..|.
Mosquito   699 QFPSNFFYEGSLQNG-----VCADERKLKVDFPWPSPDCPMFFLVTQGQEEIAGSGTSYLNRTEA 758

  Fly   915 DVVMDYVKDLMYFGLNGEKLLQTDIGIISPYKN------QYQRIQEQLNMRNWSQIDCGSVELFQ 973
            ..|.......:..|:..::     ||||:||:.      ||.:.|..|:.:.:.:|:..||:.||
Mosquito   759 SNVEKITTRFLKAGIKPDQ-----IGIITPYEGQRAYLVQYMQYQGSLHSKLYQEIEIASVDAFQ 818

  Fly   974 GKEKHVIIVSFVRSFTPK-LGFLNNERRLNVLLSRPISLLILIGNPRTLSQNSDFQHIIEMCRNR 1037
            |:||.:||:|.||:...: :||||:.|||||.|:|....:|::|||:.|::...:.|::...:::
Mosquito   819 GREKDIIIMSCVRANEHQGIGFLNDPRRLNVALTRAKYGIIIVGNPKVLAKQELWNHLLNFYKDK 883

  Fly  1038 KTLVGEQYLN---EDFI--TNKKTGANNVNKGGAAGDQPASGLRQPLKRKNHAKNPVQDAKIFYS 1097
            |.|| |..||   |..|  |..|...|.:|.|...........::.|......:||.....  |:
Mosquito   884 KVLV-EGSLNNLKESMIQFTKPKKIINTLNPGSHFMTNAMYDAKEVLGGGYFDRNPGPSTS--YA 945

  Fly  1098 KNELLNLGNECQRKKSELETIFDELPKVPRSVDHDLDEVRSIEAQLKDFQLETKQDAAGTSILVT 1162
            .|.|...||.....:.  :..|.::|....|     ....|....|..|..:........|...|
Mosquito   946 HNPLAGYGNASAYHQQ--QGGFVDVPGHGGS-----GTTASANTPLDAFMRKVHDPIGYISPQRT 1003

  Fly  1163 NAPVTNAAAP-------SVIPRAGLMKQETPALHSSSVSRPAIRKPTVS--------AATPVAKS 1212
            :..|:|...|       |..|.....:|:..|:.::..:|..:...|.|        :.:...||
Mosquito  1004 HPAVSNMPVPVGMFINMSNAPSRFYQQQQQAAIQAAKQTRRPVVGKTASQLLASGSVSTSSGGKS 1068

  Fly  1213 RSPMPEIPSSS 1223
            ..|.|..|.||
Mosquito  1069 SRPRPIGPPSS 1079

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6701	NP_001188923.1	TIGR00376	424..1037	CDD:273041	169/663 (25%)
		AAA_19	618..687	CDD:289986	31/76 (41%)
		AAA_12	812..1019	CDD:289832	69/219 (32%)
AgaP_AGAP001133	XP_322028.4	UPF1_Zn_bind	106..257	CDD:286500
		DNA2	130..897	CDD:224037	192/728 (26%)
		AAA_19	466..>523	CDD:289986	28/62 (45%)
		AAA_12	669..865	CDD:289832	69/219 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D27889at6960
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820