DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6701 and zgrf1

DIOPT Version :9

Sequence 1:	NP_001188923.1	Gene:	CG6701 / 36550	FlyBaseID:	FBgn0033889	Length:	1333	Species:	Drosophila melanogaster
Sequence 2:	XP_031758647.1	Gene:	zgrf1 / 100327248	XenbaseID:	XB-GENE-6461443	Length:	1948	Species:	Xenopus tropicalis

Alignment Length:	1288	Identity:	277/1288 - (21%)
Similarity:	453/1288 - (35%)	Gaps:	406/1288 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 DFPTPPPTPPINAGIKPPGTYAN--------------GMPRKPTVPWERELMGSFLLEMARLQVI 70
            |||..|.|..:     |.||:.|              |..::....|:       |.:....:.|
Frog   817 DFPAKPGTVHV-----PQGTHCNNAVPFKAFALPQWDGGTQQSDCDWD-------LSQWPSRETI 869

  Fly    71 SAQTEWYVDKAKMRKLFEVHLNALPNSSEIR------QKLSSQGAT--NIGSLLHRTNFLINTPR 127
            ........:|..:.:.|..|.|.:....|::      |.:|...:|  .:||.|.|...::.||
Frog   870 KPDLTIVQEKPDIDRPFSWHENTIMQLKELKDTQNATQDISCTNSTISQVGSKLQRLLPVVTTP- 933

  Fly   128 GNPNYRIKNFSLMDFRKEKFNLLDEQHRLRGIASTTDVPGGAPAEGNKPIIEEYK---LDTDVKP 189
                                :|.|         ||..||.|          .|||   |||:..|
Frog   934 --------------------DLAD---------STRPVPAG----------YEYKKCFLDTNCSP 959

  Fly   190 TLLKFQKRLLLQSDKDFELQSLGCYICQENFEKIEKYEEHVEYHGDESDFQSLKKMKKYPTPIVS 254
            :...:..:.|:    |..:.:          ..:|..||...:.....|..|.|:..|:
Frog   960 SPNIYTTKNLI----DVPVHN----------AFVENIEEGTGFLKPTEDRNSPKRQSKW------ 1004

  Fly   255 LSYQT---C-----------VDSHYFG---FTLKTFRKDLVVDK-----FIIVQLRQFYYVYGAQ 297
            ..||.   |           .:..:|.   |..:.:..|.|.||     ..:..|:.
Frog  1005 TKYQNKSLCSRTNENVEDMKANEEFFAKSLFGKEPYMADKVDDKASVESICLTLLKD-------- 1061

  Fly   298 MPLPVNGSGELVFFVDSHVFMILREQPIVIGFTIQGEKYVEQHHFMRTEALPKASFNIN---PYR 359
             .|....|| ||    .|.....|...|.|....:|          :|..|..:|.|:.   ...
Frog  1062 -TLSKKNSG-LV----QHGLHTKRHPTISIAQLNKG----------KTSFLSDSSGNVKISCELH 1110

  Fly   360 LSSKETFKSK-GLPPANPPIQVLSALKHEDAQMCLASFDNQYQNYCERGREITQENLTGTLRTLL 423
            ..|:||.:|. .:|.....|.:|                  ||:.... :.:....||..| .::
Frog  1111 FPSRETVQSTVSIPKREISIPIL------------------YQSVTHY-KHVFTAALTEHL-NIM 1155

  Fly   424 QVEDIERLQHYLSLKQSEMELHQFGRELSVKMQMGTTSMSVEDILSPGDDVLIINEKGN------ 482
            ..|..:||  |.:|.:.:|..:...|......:...|.:.:..  .|...|::..|..|
Frog  1156 MFELSQRL--YKALSKVDMSFYTSSRAAGEMGKHNVTPLCLHQ--QPAKLVMVKKEGPNKGRFFY 1216

  Fly   483 ----PKSAVRKMLENNNNVL-----------ELALKDFDSILRWARN---------------VDG 517
                |||...|..:..|...           ::.:.|..|:..:.|:               |.|
Frog  1217 TCDAPKSDQCKFFKWLNETQCSSPVQGHAQPKVVMGDMKSVASFVRSHKVALYEESHLMVRKVSG 1281

  Fly   518 MVG-SLDKQPRVYFAR--ILGVSTQRVNITCERQLPDNTTY----------TLIFRPLRAVMRY- 568
            ... |..|..::..|.  ..|.|..::.:...|: .:::.|          |:.|.|:...:.:
Frog  1282 FQNKSFGKFKKIINANSDFAGESKTKLYLKLNRK-ENSSAYSKDDLWVVSKTIDFEPVDTFVAFS 1345

  Fly   569 -----------QYRALQQLS---------------------FTRHSDVQRILFPGEIP------- 594
                       :.:.|:..|                     .|...::|..|.|..:|
Frog  1346 VFFGPSANNEIEIQPLKGYSPSNWPSNTLVHAVLVCNASTELTSLRNIQEHLNPSTLPIMPHLLK 1410

  Fly   595 -----------NT------------------PLASGVLQLNNKLIS---TNPEQMQAVRQIA-LS 626
                       ||                  |..|.:|..:.::|.   .|.:|..|:.||| :.
Frog  1411 MQSEQEGESKTNTGKFKPPSLTAKIPQRCELPSCSFILAKSQEMIEQFRLNEDQATALMQIAQMM 1475

  Fly   627 PRLKAPYIVFGPP--------GTGKT---STIVEAIYQLYI--NRPETH------ILVLAGSNTA 672
            ......|....||        |.||:   |.:|..:.||:.  |..|.:      ||:.:.:|.|
Frog  1476 TTAAGSYKAVAPPITVIHGVFGAGKSYLLSVVVLFLVQLFERGNPAEGYEASPWKILISSSTNVA 1540

  Fly   673 CDEVALRLL-------------RAIAKAPQSQPRPLTRIFS--ANCDRRIDNIDDLL-LEYSNMY 721
            .|.|.|.||             |.|||       |:.. ||  |..:...:.|.:|| |...::.
Frog  1541 VDRVLLGLLDLGFSQFVRVGSIRKIAK-------PILP-FSLHAGSENENEQIKELLALLKDDLT 1597

  Fly   722 TVHFYPAVQAVHQYRIVICTLSLAGKLSTGG-------FA--ANNVYTHVFVDEAAASTEAEVLM 777
            .|......:::.|:::. ...:|.|::...|       ||  :|..:..|.:||.:..||...::
Frog  1598 PVEKAYVRKSIEQHKLG-TNKALLGQVRVVGATCAACPFACMSNLKFPVVVLDECSQMTEPASML 1661

  Fly   778 GIT---CTLSPTLNLILSGDHKQLGPVLQ-SQRANEWGLGLTLFERLLQRKCYQVEEDGSYNASV 838
            .:.   |.     .|||.||.|||.|.:| |:.|:|.||..|||.||    |..     .:.|.:
Frog  1662 PVARFQCE-----KLILVGDPKQLSPTIQGSEPAHEKGLEQTLFSRL----CLM-----GHKAII 1712

  Fly   839 QTRLIRNFRSHPEIVSLYNNMYYEGHLRTEAPMEIVCRFHNWFYLPNATFPIMFHSVFGTTMNTK 903
               |...:|.||.|.|:.|.::|:.||......|......:|  ||.    :.|::|.||. ..:
Frog  1713 ---LRTQYRCHPAICSIANELFYDSHLINGVSEEDRKPLLDW--LPT----LCFYNVNGTE-QVE 1767

  Fly   904 SSVSLCNNKEIDVVMDYVKDLMYFGLNGEKLLQTDIGIISPYKNQYQRIQEQL------NMRNWS 962
            .:.|..|.:|.:..:..::.|:..|:.|..     ||:|:.||:|..:|...|      :..:..
Frog  1768 GNNSFYNMEEANFTVKLIQSLIASGIEGSM-----IGVITLYKSQMYKIFSLLASSAHCDSTDIK 1827

  Fly   963 QIDCGSVELFQGKEKHVIIVSFVRSFTPKLGFLNNERRLNVLLSRPISLLILIGNPRTLSQNSDF 1027
            .:...:|:.|||.||.:||:|.||  |.::||:::|:|:||.|:|....|::|.|...|.:|..:
Frog  1828 AVQVSTVDAFQGAEKEIIILSCVR--TRQVGFIDSEKRMNVGLTRGKRHLLIIANLACLRKNKLW 1890

  Fly  1028 QHIIEMCRNRKTLV-----GEQYLN-----------EDFITNKKTGAN--NVN 1062
            :|:|..|..:|..:     .|:.||           |:.:..||:.|.  |||
Frog  1891 EHVIHHCERQKNGLKHVSQWEEKLNAILLRYQEKKIEEDMKKKKSKARECNVN 1943

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6701	NP_001188923.1	TIGR00376	424..1037	CDD:273041	180/788 (23%)
		AAA_19	618..687	CDD:289986	28/101 (28%)
		AAA_12	812..1019	CDD:289832	63/212 (30%)
zgrf1	XP_031758647.1	DUF2439	6..71	CDD:402138
		zf-GRF	1191..1234	CDD:399670	8/44 (18%)
		DEAD-like_helicase_N	1460..1718	CDD:421690	76/283 (27%)
		AAA_12	1695..1880	CDD:404073	62/210 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910