Protein Alignment CG6701 and helz

DIOPT Version :9

• Sequence 1: NP_001188923.1
• Gene: CG6701 / 36550
• FlyBaseID: FBgn0033889
• Length: 1333
• Species: Drosophila melanogaster
• Sequence 2: XP_031749843.1
• Gene: helz / 100145753
• XenbaseID: XB-GENE-5912847
• Length: 1948
• Species: Xenopus tropicalis
• Alignment Length: 1627
• Identity: 344/1627 - (21%)
• Similarity: 556/1627 - (34%)
• Gaps: 544/1627 - (33%)

  Fly    22 PTPPPTPPINAGIKPPGTYANGMPRKPTVPWERELMGSFLLEMARLQVIS--------AQTEWY- 77
            ||.|||.|                                 |::|:|..|        .|.:.|
 Frog    43 PTNPPTQP---------------------------------ELSRIQTESLLYRIASFLQLKNYD 74

  Fly    78 ----------------VDKAKMRKLFEVHLNA-LPNSSEIRQK---------LSSQGATNIGSLL 116
                            :|.:....|..:||.. |...|.:..|         |.::..|.:..||
 Frog    75 QADEDCRHVLGPGRTRLDSSVHAVLCSLHLEGKLQAVSSVLSKCLAGETLNGLVTKDLTRLKILL 139

  Fly   117 HRTNFLINTPRGNPNYRIKNFSLMDFRKEKFNLLDE------QHR--LRGIASTTDVPGGAPAEG 173
            .....:.||.|.:    .....|.|.....|.:.|.      |.|  .||:.|:
 Frog   140 AEIETVSNTVRSS----YHGDDLEDGTNCSFTIYDGGSHDGWQFRPPPRGVTSS----------- 189

  Fly   174 NKPIIEEYKL-----------------DTDVKPTLLKFQKR-----LLLQSDKDFELQSLGCYIC 216
                 |||.|                 ....:..|.::|||     :.|:..|: ..|..|.|:
 Frog   190 -----EEYTLCKRFLEQGICRYGAQCTSAHSQEELEEWQKRYASRLIRLKQQKE-NTQFSGSYM- 247

  Fly   217 QENFEKIEKYEE---------------HVEYHGDESDFQSLKKMKKYPTPIVSLSYQTCVDSHYF 266
             |:.  |||:..               ||||..|.|...:.||           |:||..    |
 Frog   248 -ESL--IEKWMNSLSPEKVLSECADGVHVEYSPDLSVTVTTKK-----------SHQTWT----F 294

  Fly   267 GFTLKTFRKDLVVDKFIIVQLRQFYYVYGAQMP-------------------------------L 300
            ..|.|..|           .|::...:|.|..|                               :
 Frog   295 LLTCKPAR-----------PLQRVALLYDAHRPHFSIVAIAAGDSNSQVSQEVPESCQEWVGGNM 348

  Fly   301 PVNGSGELVFFV----DSHVFMILREQPIVIGFTIQGEKYVEQHHFMRTEALPKASFNINPYRLS 361
            ..||....::.|    .:.:|...| |.:|..|   |.:.|.....|    :..||.....|.:.
 Frog   349 AQNGMDHCIYKVVIAFTTEIFGTFR-QTVVFDF---GAEPVLMQRIM----VDAASTEDLEYLMH 405

  Fly   362 SKETFKSKGLPPANPPIQVLSALKHEDA-QMCLASFDNQYQNYCERG------------------ 407
            :::              |:|:..|..|: ...:..|:.......||.
 Frog   406 ARQ--------------QLLTTAKRWDSMSKTIVEFEPNETTEMERSLLSRYQIPLSADQLFTQS 456

  Fly   408 ---REITQENLTGTLRTLLQVEDIERLQHYLSLKQSEMELHQFGRELSVKMQMGTTSMSVEDILS 469
               :.:|:.|....|..||.:|:|.:.:          |:.:|  .:.|::|:..:.|
 Frog   457 VLDKSLTKCNYQARLHDLLYIEEIAQYK----------EVSKF--NIKVQLQLVASFM------- 502

  Fly   470 PGDDVLIINEKGNPKSAVRKMLENNNNVLE----------LALKDFDSILRWARNVDGMVGSLDK 524
                  :....|..|.|....|.....:.|          |.:...:::.......:..|.|...
 Frog   503 ------LTGVSGGAKYAQNGQLFGRFKLTETLSEDTLAGRLVMTKVNAVYVLPVTKERSVQSQGT 561

  Fly   525 QPRVY------------FARILGVSTQRVNITCERQLPDNTTYTLIFRPLRAVMRYQYRALQQLS 577
            :.:||            |.||.......:.:..:|::.....:.|...|| ..|.|....::..|
 Frog   562 KEKVYEAVIEEKTKDYIFLRICKDCCDELKLKPDREMQVELQFQLNRLPL-CEMHYALDRVKDNS 625

  Fly   578 FTRHSDVQRILFPG-----EIPNTPLASGVLQLNNKLISTNPEQMQAVRQIA--LSPRLKAPYIV 635
                     ||||.     .||.:|.......|:.:|   |.:|.:|:..|.  ||.:| .|.::
 Frog   626 ---------ILFPDLSMTPPIPWSPNRQWDELLDPRL---NAKQKEAILAITTPLSVQL-PPILI 677

  Fly   636 FGPPGTGKTSTIVEAIYQLYINRPETHILVLAGSNTACDEVALRLLRAIAKAPQSQPRPLTRIFS 700
            .||.|||||.|:.:|:..: :.:.||.:|:...||:|.|......|....:....|.||| |::.
 Frog   678 IGPYGTGKTFTLAQAVKHI-LKQQETRVLICTHSNSAADLYIKDYLHPYVETGNPQARPL-RVYF 740

  Fly   701 ANCDRRIDNIDDLLLEY---SNMYTVHFYPAVQAVHQYRIVICTLSLAGKLS----TGGFAANNV 758
            .|  |.:..:..::.:|   |:.::|...|..:.:.|:|:|:.|||.:..|.    ..||
 Frog   741 RN--RWVKTVHPVVHQYCLISSTHSVFQMPQKEDILQHRVVVVTLSTSQYLCQLDLEPGF----- 798

  Fly   759 YTHVFVDEAAASTEAEVLMGITCTLSPTLNLILSGDHKQLGPVLQSQRANEWGLGLTLFERLLQR 823
            :||:.:||||.:.|.|.:|.:... |.:..::|:|||.||.|.:.|:.|.|..|.::|.:||
 Frog   799 FTHILLDEAAQAMECETIMPLALA-SKSTRIVLAGDHMQLSPFVYSEFARERNLHVSLLDRL--- 859

  Fly   824 KCYQVEEDGSYNASVQTRLI--RNFRSHPEIVSLYNNMYYEGHLRTEAPMEIVCRFHNWFYLPNA 886
              |::     |......|::  .|:|||..|::..:.::|||.|........    |..||
 Frog   860 --YEL-----YPVDFPCRILLCENYRSHEAIINYTSELFYEGKLMASGKQPA----HKDFY---- 909

  Fly   887 TFPIMFHSVFGTTMNTKSSVSLCNNKEIDVVMDYVKDL-----MYFGLNGEKLLQTDIGIISPYK 946
              |:.|.:..|..:..|:|.:..||.|:..|::.|::|     :.:|    ||.:..||:::||.
 Frog   910 --PLTFFTARGEDVQEKNSTAFYNNAEVFEVVERVEELRRKWPVAWG----KLDEGSIGVVTPYA 968

  Fly   947 NQYQRIQEQLNMRNWSQIDCGSVELFQGKEKHVIIVSFVRS-------FTP-------------- 990
            :|..||:.:|..:..|:|....|...|||:..|:.:|.||:       .||
 Frog   969 DQVFRIRAELRKKRLSEISVERVLNVQGKQFRVLFLSTVRTRHTCKHKQTPIKRKEQLLEDSTED 1033

  Fly   991 -KLGFLNNERRLNVLLSRPISLLILIGNPRTLSQ----NSDFQHIIEMCRNRKTLVG---EQYLN 1047
             ..|||:|.:.||..::|..||:.::|:|..|..    ...::..|.:|...|:|.|   ||..:
 Frog  1034 LDYGFLSNYKLLNTAITRAQSLVAVVGDPIALCSIGRCRKFWEQFISICHENKSLHGITFEQIKS 1098

  Fly  1048 E-DFITNKKTGANNVNKGGAAGDQPASGLRQPLK--------RKNHAKNPVQD--------AKIF 1095
            : :.:..|||...|                 ||.        |:.|:.||.:.        .|..
 Frog  1099 QLEALELKKTYVLN-----------------PLAPEFIPRALRQQHSGNPSKQQQQQSPPKCKGH 1146

  Fly  1096 YSKNELLNLGNECQRKKSELETIFDEL-----PKVPRS-VDHDLDEVRSIEAQLKDFQLETKQDA 1154
            :::|:........|:..|.|  |.:.:     |..|.| :......|:.|:..
 Frog  1147 HNQNDHFPGDGLVQQNPSVL--IGNPIRAYTPPLGPHSNIGKSPSPVQRIDPH------------ 1197

  Fly  1155 AGTSILVTNA-----PVTNAAAP----------SVIPRAGLMKQETPAL---------------- 1188
            .|||||...|     .|.:...|          ||.||  ||.....|.
 Frog  1198 TGTSILYVPAVYGGNMVMSVPLPVPWPSYQGRFSVDPR--LMTHTAMAYNMNLLQAHGRGSPIPF 1260

  Fly  1189 ---HSSSVSRPAIRKPTV------------------------SAATPVAKSRSPMP--EIPSSSK 1224
               |.|.|:....::|..                        ...||..|...|.|  ..|::.:
 Frog  1261 GLGHHSPVNVGPPQQPLQHPDKDQHEQHRNGKSESNQGTDLNKLRTPEKKPLEPKPGDMDPNAQR 1325

  Fly  1225 HPISMSS----NP----LSTNTERCVNGVLCGIEAVPPSENKTTRSSAYNHI-----PSGNFRFE 1276
            .|.|..:    ||    ....::|.:|     :...||.......|..|.|:     |..:.:.:
 Frog  1326 SPDSRGNTAFLNPKFHRKENPSQRHLN-----VHLAPPQPQFPLPSRHYQHLSQLQRPPFSIQQQ 1385

  Fly  1277 NV---------------RPTPEE-VRRFN-----GANDQRRARPFREPHGNWSNFGWSPPPRDPT 1320
            ||               .|.|.: |.:.|     .|....:..|...|..|.|.|. :|.|..|.
 Frog  1386 NVLTQQQNHLSELQNQIPPQPGQLVPQLNHLTQPPAPQGSQLSPAFPPGANHSFFN-NPMPGRPH 1449

  Fly  1321 PP 1322
            .|
 Frog  1450 SP 1451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6701	NP_001188923.1	TIGR00376	424..1037	CDD:273041	168/681 (25%)
		AAA_19	618..687	CDD:289986	23/70 (33%)
		AAA_12	812..1019	CDD:289832	63/235 (27%)
helz	XP_031749843.1	zf-CCCH	192..216	CDD:395517	2/23 (9%)
		DEXXQc_HELZ	652..878	CDD:350835	74/249 (30%)
		AAA_12	851..1062	CDD:404073	63/234 (27%)
		Atrophin-1	<1154..>1471	CDD:397323	62/320 (19%)
		PHA03247	<1403..1831	CDD:223021	14/50 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D286011at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010