DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6701 and setx

DIOPT Version :9

Sequence 1:	NP_001188923.1	Gene:	CG6701 / 36550	FlyBaseID:	FBgn0033889	Length:	1333	Species:	Drosophila melanogaster
Sequence 2:	XP_002936221.1	Gene:	setx / 100145435	XenbaseID:	XB-GENE-966858	Length:	2535	Species:	Xenopus tropicalis

Alignment Length:	1554	Identity:	311/1554 - (20%)
Similarity:	539/1554 - (34%)	Gaps:	460/1554 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 KPPGTYANGMPRKPTVPWERELMGSFLLEMARLQVISAQTEWYVD---KAKMRKLFEVHLNALPN 96
            ||    :.|:.:||......   |:|     .::.:|:.:.:..|   .||.::...:|.:....
Frog  1075 KP----SKGLQKKPKAKGSE---GTF-----SVKGVSSSSFYRKDVPIAAKHKEKANIHTSPKKT 1127

  Fly    97 SS-------------EIRQKLSSQGATN--------IGSLLHRTNFLINTPRGNPNYRIK----- 135
            ||             .:.||:.|:...|        .|..:.|.|.:..:|...|..:|:
Frog  1128 SSLSSKVVRGKKTETVVAQKIISKSKANRTKSPLRSRGENVRRENLIRTSPAVVPPKKIRMAPEP 1192

  Fly   136 --NFSLMDFRKEKFNLLD-EQHRLRGIASTTDVPGGAPAEGNKPIIEEYKLDTDVKP--TLLKFQ 195
              ....:.|:|......| .|..|..:|...:  .|..|...:|...:.||   :.|  .|:|..
Frog  1193 SSTAEKLGFKKAPRKAFDLSQRSLDSVAELRN--HGKMAGFVEPKKTKAKL---ISPQSLLVKCN 1252

  Fly   196 KRLLLQSDKDFELQS--------LGCYICQENFEKIEKYEEHVEYHGDESD--FQS----LKKMK 246
            |::|...|..|..||        ......::...|||.....::.:|..|.  ||:    .:.:.
Frog  1253 KKMLACQDLQFYRQSRPNVPGKRKQAEALEDGNRKIENAAHKIDKNGTSSSRHFQATTSHAEAIS 1317

  Fly   247 KYPTPIVSLSYQTCVDSHYFGFTLKTFRKDL------------------VVDKFIIVQLRQFYYV 293
            ..|.....||    :.:.:...:..:..|..                  |::| ::.......:|
Frog  1318 NKPRDERKLS----ISNEHLEISRTSSNKSTAQNGEISLNSKLEKSSSHVLEK-LVTSADDNAFV 1377

  Fly   294 YGAQMPLPVNGSGELVFFVDSHVFMILREQPIVIGFTIQGEKYVEQHH--------FMRTEA--- 347
                  ||.....|...:.|.:...:.:..|:.:....|.|..::...        |..::|
Frog  1378 ------LPPTNEKESNNYEDDYDLFLTQADPVDMEMCSQVEYDIDLDEGGASRVSDFSGSDAELP 1436

  Fly   348 ---------LPKASFNIN------------------------PYRLSSKETFKSKGLPP--ANPP 377
                     |||...|..                        |...:....|...||||  :.|.
Frog  1437 KLATGSGTELPKMGLNDGVPKCKYTNCTEMVKVAGDHCPKHMPPEKADDHLFAKPGLPPSVSKPS 1501

  Fly   378 IQVLSALKHEDAQMCLASFDNQYQNYCE-RG-----------------REITQENLTGTLRTLLQ 424
            ...:.|..:...   .||.....:|:.. :|                 :.:|.:|......::||
Frog  1502 TTKVFASSNTSR---TASLTKDLENFPRPQGILKAKPQSAKAPVPKLPKPLTVQNRASDTNSVLQ 1563

  Fly   425 ----------------VEDIERLQHYLSLKQSEM--------ELHQFGRELSVKM-QMGTTS--- 461
                            |.:..:|:.|.:.|..:.        ||.|:..|:...: :.|..|
Frog  1564 PLINQSNVPSKPSYSAVSEAGKLRPYAAQKPLQQRDQGWLMRELLQWKFEMFDNVSRFGPPSNLC 1628

  Fly   462 -----------MSVEDILSPGDDVLIIN---EKGNPKSAVRKMLENNNNVLELALKDF--DSILR 510
                       .|.|:..:....::::|   ......|..:|.:  :.::.:|.|::|  |.::.
Frog  1629 QLPLLKVPIKFSSYEEYFNVFFPLMLLNTFESLAQEWSVKQKAI--HTDLCKLHLQNFCPDGLVN 1691

  Fly   511 ------WARNVDGMVGSLDKQPRVYF-------------------ARILGVS-TQRVNITCERQL 549
                  |.|:.|..:....|:..:.|                   ||:.... ..|.|.:...|.
Frog  1692 RGEFQVWFRDADLCMQRHPKEDDLVFLCMPESTPSLSGEEMVSHGARVYHTGYVSRFNRSHRTQS 1756

  Fly   550 PDNTTYTL------------IFRPLR---AVM------RYQYRALQQLSFTRHSDVQRILFPGEI 593
            .:...|||            .||..:   ||:      :.|:|||.||.  |:...:.|:.|...
Frog  1757 QEKEQYTLCDLCIHTQGNLSAFRNQQVRCAVIGSLITTQRQFRALLQLQ--RNPLFRPIILPNPA 1819

  Fly   594 PNTPLASGVLQLNN--KLISTNPEQMQAVRQ----IALSPRLKAPYIVFGPPGTGKTSTIVEAIY 652
            ...|..:...:.::  .|...|.:|..|:.:    :...|||....::.|||||||:.|||..:|
Frog  1820 DFIPRDNAASESSSFPSLKEYNSDQRYAIEKAYSMVKQHPRLPRICLIHGPPGTGKSKTIVGLLY 1884

  Fly   653 QLYI--------------NRPETHILVLAGSNTACDEVALRLLRAIAKAPQSQPRP--------L 695
            ::.:              ......:||.|.||.|.|::..:::....:...::..|        |
Frog  1885 RILMENGSSTVPVQNLSAKNKRNRVLVCAPSNAALDDLMKKIILEFKEKCHNKNTPLGNCGDINL 1949

  Fly   696 TRI------------FSANC----------------------DRRIDN----------------- 709
            .|:            ||.:|                      |||:|.
Frog  1950 VRLGAEKTISSDVVKFSLDCQVNHRITRAQQDQELHKRKELLDRRLDELSRRRALEKCNKNTCAP 2014

  Fly   710 IDDLLLEYS--------NMYTVHFYPAV---QAVHQYRIVICTLSLAGKLSTGGFAANNVYTH-- 761
            :|:.:...|        ::..|...|..   ..:.:..::.||||     ::||....:.:..
Frog  2015 LDEEIARLSKERQLLADSLKLVRRRPQELQRTIILESHVICCTLS-----TSGGILLESAFRQLG 2074

  Fly   762 ------VFVDEAAASTEAEVLMGITCTLSPTLNLILSGDHKQLGPVLQSQRANEWGLGLTLFERL 820
                  |.||||..|.|.|.|:.:   |.....|:|.||.:||.|.:.|.:|.|.|.|    :.|
Frog  2075 QEPFSCVIVDEAGQSCEVENLIPL---LHRCSKLVLVGDPEQLPPTVISMKAEELGYG----QSL 2132

  Fly   821 LQRKCYQVEEDGSYNASVQTRLIRNFRSHPEIVSLYNNMYYEGHLRTEAPMEIVCRFHNWFYLPN 885
            :.|.|..::..|:  .|....|...:|.||:|....::.:|:..|:|:...|.|....:|.:.|.
Frog  2133 MSRMCSFLDSTGT--KSPVLHLTVQYRMHPDICLFPSHYFYKRMLKTDRATEEVRCSSDWPFQPY 2195

  Fly   886 ATFPIMFHSVFGTTMNTKSSVSLCNNKEIDVVMDYVKDLMYFGLNGEKLLQT--------DIGII 942
            ..|.:      ......|...|.||.:||.|.:..:           ||:::        :||:|
Frog  2196 MVFDV------ADGFEQKERESFCNPQEIKVAVALI-----------KLIKSRKKEFCFRNIGVI 2243

  Fly   943 SPYKNQYQRIQEQLNMRNWSQIDCGSVEL---FQGKEKHVIIVSFVRSFTPK--LGFLNNERRLN 1002
            :||:.|..||.|:|.....:.|..|.|:.   |||::|..|||:.||:.:.:  :|||.:.:|||
Frog  2244 TPYRAQKMRIIEELRRAFGNDIRPGEVDTVDGFQGRQKDCIIVTCVRANSTQGGIGFLASRQRLN 2308

  Fly  1003 VLLSRPISLLILIGNPRTLSQNSDFQHIIEMCRNRKTLV--GEQYLNEDF--ITNKKTGANNVNK 1063
            |.::|....|.::|:.|||.:|.|:.|:|:..:.|..|:  .|::...|.  |...|.....
Frog  2309 VTITRAKFSLFILGSLRTLMENKDWNHLIQDAQRRGALIKTREEHYQRDVGKILKLKPVVQR--- 2370

  Fly  1064 GGAAGDQPASGLRQPLKRKNHAKNPVQDAKIFYSKNELLNLGNECQRKKSELETIFDELPKVPRS 1128
               |...|.|  |...|:|:.:..|.:                 .:..|...:.....||...|.
Frog  2371 ---APIHPNS--RPEEKQKDSSAPPPR-----------------IEPPKETTQPPRKPLPAPSRP 2413

  Fly  1129 VDHDLDEVRSIEAQLKDFQLETKQDAAGTSILVTNAPVTNAAAPSVIPRAGLMKQETPALHSSSV 1193
            |.|.              .::.::|:..|.    |||..:|..|  :|.|...|.:.|.|.....
Frog  2414 VIHP--------------AVDFRRDSFNTH----NAPSGSAVGP--LPPAPRSKLQDPRLARWQE 2458

  Fly  1194 SRPAIRKPTV--SAATPVAKSRSPMPEIPSSSKHPI----------SMSSNPLSTNTER 1240
            ::.....||.  |.|.....|..|...:...| ||.          |.|||..:.:.:|
Frog  2459 TKTDTSPPTTLDSNARISTHSSHPSSSVAGGS-HPARRDSRAVSDGSRSSNSWNRDRDR 2516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6701	NP_001188923.1	TIGR00376	424..1037	CDD:273041	180/814 (22%)
		AAA_19	618..687	CDD:289986	22/86 (26%)
		AAA_12	812..1019	CDD:289832	60/219 (27%)
setx	XP_002936221.1	DEXXQc_SETX	1840..2157	CDD:350800	72/330 (22%)
		AAA_12	2128..2323	CDD:404073	59/217 (27%)
		PHA03247	<2365..2534	CDD:223021	40/198 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148890at33208
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920