Protein Alignment CG6701 and setx

DIOPT Version :10

• Sequence 1: NP_610920.3
• Gene: CG6701 / 36550
• FlyBaseID: FBgn0033889
• Length: 1333
• Species: Drosophila melanogaster
• Sequence 2: XP_002936221.1
• Gene: setx / 100145435
• XenbaseID: XB-GENE-966858
• Length: 2535
• Species: Xenopus tropicalis
• Alignment Length: 1554
• Identity: 311/1554 - (20%)
• Similarity: 539/1554 - (34%)
• Gaps: 460/1554 - (29%)

  Fly    35 KPPGTYANGMPRKPTVPWERELMGSFLLEMARLQVISAQTEWYVD---KAKMRKLFEVHLNALPN 96
            ||    :.|:.:||......   |:|     .::.:|:.:.:..|   .||.::...:|.:....
 Frog  1075 KP----SKGLQKKPKAKGSE---GTF-----SVKGVSSSSFYRKDVPIAAKHKEKANIHTSPKKT 1127

  Fly    97 SS-------------EIRQKLSSQGATN--------IGSLLHRTNFLINTPRGNPNYRIK----- 135
            ||             .:.||:.|:...|        .|..:.|.|.:..:|...|..:|:
 Frog  1128 SSLSSKVVRGKKTETVVAQKIISKSKANRTKSPLRSRGENVRRENLIRTSPAVVPPKKIRMAPEP 1192

  Fly   136 --NFSLMDFRKEKFNLLD-EQHRLRGIASTTDVPGGAPAEGNKPIIEEYKLDTDVKP--TLLKFQ 195
              ....:.|:|......| .|..|..:|...:  .|..|...:|...:.||   :.|  .|:|..
 Frog  1193 SSTAEKLGFKKAPRKAFDLSQRSLDSVAELRN--HGKMAGFVEPKKTKAKL---ISPQSLLVKCN 1252

  Fly   196 KRLLLQSDKDFELQS--------LGCYICQENFEKIEKYEEHVEYHGDESD--FQS----LKKMK 246
            |::|...|..|..||        ......::...|||.....::.:|..|.  ||:    .:.:.
 Frog  1253 KKMLACQDLQFYRQSRPNVPGKRKQAEALEDGNRKIENAAHKIDKNGTSSSRHFQATTSHAEAIS 1317

  Fly   247 KYPTPIVSLSYQTCVDSHYFGFTLKTFRKDL------------------VVDKFIIVQLRQFYYV 293
            ..|.....||    :.:.:...:..:..|..                  |::| ::.......:|
 Frog  1318 NKPRDERKLS----ISNEHLEISRTSSNKSTAQNGEISLNSKLEKSSSHVLEK-LVTSADDNAFV 1377

  Fly   294 YGAQMPLPVNGSGELVFFVDSHVFMILREQPIVIGFTIQGEKYVEQHH--------FMRTEA--- 347
                  ||.....|...:.|.:...:.:..|:.:....|.|..::...        |..::|
 Frog  1378 ------LPPTNEKESNNYEDDYDLFLTQADPVDMEMCSQVEYDIDLDEGGASRVSDFSGSDAELP 1436

  Fly   348 ---------LPKASFNIN------------------------PYRLSSKETFKSKGLPP--ANPP 377
                     |||...|..                        |...:....|...||||  :.|.
 Frog  1437 KLATGSGTELPKMGLNDGVPKCKYTNCTEMVKVAGDHCPKHMPPEKADDHLFAKPGLPPSVSKPS 1501

  Fly   378 IQVLSALKHEDAQMCLASFDNQYQNYCE-RG-----------------REITQENLTGTLRTLLQ 424
            ...:.|..:...   .||.....:|:.. :|                 :.:|.:|......::||
 Frog  1502 TTKVFASSNTSR---TASLTKDLENFPRPQGILKAKPQSAKAPVPKLPKPLTVQNRASDTNSVLQ 1563

  Fly   425 ----------------VEDIERLQHYLSLKQSEM--------ELHQFGRELSVKM-QMGTTS--- 461
                            |.:..:|:.|.:.|..:.        ||.|:..|:...: :.|..|
 Frog  1564 PLINQSNVPSKPSYSAVSEAGKLRPYAAQKPLQQRDQGWLMRELLQWKFEMFDNVSRFGPPSNLC 1628

  Fly   462 -----------MSVEDILSPGDDVLIIN---EKGNPKSAVRKMLENNNNVLELALKDF--DSILR 510
                       .|.|:..:....::::|   ......|..:|.:  :.::.:|.|::|  |.::.
 Frog  1629 QLPLLKVPIKFSSYEEYFNVFFPLMLLNTFESLAQEWSVKQKAI--HTDLCKLHLQNFCPDGLVN 1691

  Fly   511 ------WARNVDGMVGSLDKQPRVYF-------------------ARILGVS-TQRVNITCERQL 549
                  |.|:.|..:....|:..:.|                   ||:.... ..|.|.:...|.
 Frog  1692 RGEFQVWFRDADLCMQRHPKEDDLVFLCMPESTPSLSGEEMVSHGARVYHTGYVSRFNRSHRTQS 1756

  Fly   550 PDNTTYTL------------IFRPLR---AVM------RYQYRALQQLSFTRHSDVQRILFPGEI 593
            .:...|||            .||..:   ||:      :.|:|||.||.  |:...:.|:.|...
 Frog  1757 QEKEQYTLCDLCIHTQGNLSAFRNQQVRCAVIGSLITTQRQFRALLQLQ--RNPLFRPIILPNPA 1819

  Fly   594 PNTPLASGVLQLNN--KLISTNPEQMQAVRQ----IALSPRLKAPYIVFGPPGTGKTSTIVEAIY 652
            ...|..:...:.::  .|...|.:|..|:.:    :...|||....::.|||||||:.|||..:|
 Frog  1820 DFIPRDNAASESSSFPSLKEYNSDQRYAIEKAYSMVKQHPRLPRICLIHGPPGTGKSKTIVGLLY 1884

  Fly   653 QLYI--------------NRPETHILVLAGSNTACDEVALRLLRAIAKAPQSQPRP--------L 695
            ::.:              ......:||.|.||.|.|::..:::....:...::..|        |
 Frog  1885 RILMENGSSTVPVQNLSAKNKRNRVLVCAPSNAALDDLMKKIILEFKEKCHNKNTPLGNCGDINL 1949

  Fly   696 TRI------------FSANC----------------------DRRIDN----------------- 709
            .|:            ||.:|                      |||:|.
 Frog  1950 VRLGAEKTISSDVVKFSLDCQVNHRITRAQQDQELHKRKELLDRRLDELSRRRALEKCNKNTCAP 2014

  Fly   710 IDDLLLEYS--------NMYTVHFYPAV---QAVHQYRIVICTLSLAGKLSTGGFAANNVYTH-- 761
            :|:.:...|        ::..|...|..   ..:.:..::.||||     ::||....:.:..
 Frog  2015 LDEEIARLSKERQLLADSLKLVRRRPQELQRTIILESHVICCTLS-----TSGGILLESAFRQLG 2074

  Fly   762 ------VFVDEAAASTEAEVLMGITCTLSPTLNLILSGDHKQLGPVLQSQRANEWGLGLTLFERL 820
                  |.||||..|.|.|.|:.:   |.....|:|.||.:||.|.:.|.:|.|.|.|    :.|
 Frog  2075 QEPFSCVIVDEAGQSCEVENLIPL---LHRCSKLVLVGDPEQLPPTVISMKAEELGYG----QSL 2132

  Fly   821 LQRKCYQVEEDGSYNASVQTRLIRNFRSHPEIVSLYNNMYYEGHLRTEAPMEIVCRFHNWFYLPN 885
            :.|.|..::..|:  .|....|...:|.||:|....::.:|:..|:|:...|.|....:|.:.|.
 Frog  2133 MSRMCSFLDSTGT--KSPVLHLTVQYRMHPDICLFPSHYFYKRMLKTDRATEEVRCSSDWPFQPY 2195

  Fly   886 ATFPIMFHSVFGTTMNTKSSVSLCNNKEIDVVMDYVKDLMYFGLNGEKLLQT--------DIGII 942
            ..|.:      ......|...|.||.:||.|.:..:           ||:::        :||:|
 Frog  2196 MVFDV------ADGFEQKERESFCNPQEIKVAVALI-----------KLIKSRKKEFCFRNIGVI 2243

  Fly   943 SPYKNQYQRIQEQLNMRNWSQIDCGSVEL---FQGKEKHVIIVSFVRSFTPK--LGFLNNERRLN 1002
            :||:.|..||.|:|.....:.|..|.|:.   |||::|..|||:.||:.:.:  :|||.:.:|||
 Frog  2244 TPYRAQKMRIIEELRRAFGNDIRPGEVDTVDGFQGRQKDCIIVTCVRANSTQGGIGFLASRQRLN 2308

  Fly  1003 VLLSRPISLLILIGNPRTLSQNSDFQHIIEMCRNRKTLV--GEQYLNEDF--ITNKKTGANNVNK 1063
            |.::|....|.::|:.|||.:|.|:.|:|:..:.|..|:  .|::...|.  |...|.....
 Frog  2309 VTITRAKFSLFILGSLRTLMENKDWNHLIQDAQRRGALIKTREEHYQRDVGKILKLKPVVQR--- 2370

  Fly  1064 GGAAGDQPASGLRQPLKRKNHAKNPVQDAKIFYSKNELLNLGNECQRKKSELETIFDELPKVPRS 1128
               |...|.|  |...|:|:.:..|.:                 .:..|...:.....||...|.
 Frog  2371 ---APIHPNS--RPEEKQKDSSAPPPR-----------------IEPPKETTQPPRKPLPAPSRP 2413

  Fly  1129 VDHDLDEVRSIEAQLKDFQLETKQDAAGTSILVTNAPVTNAAAPSVIPRAGLMKQETPALHSSSV 1193
            |.|.              .::.::|:..|.    |||..:|..|  :|.|...|.:.|.|.....
 Frog  2414 VIHP--------------AVDFRRDSFNTH----NAPSGSAVGP--LPPAPRSKLQDPRLARWQE 2458

  Fly  1194 SRPAIRKPTV--SAATPVAKSRSPMPEIPSSSKHPI----------SMSSNPLSTNTER 1240
            ::.....||.  |.|.....|..|...:...| ||.          |.|||..:.:.:|
 Frog  2459 TKTDTSPPTTLDSNARISTHSSHPSSSVAGGS-HPARRDSRAVSDGSRSSNSWNRDRDR 2516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6701	NP_610920.3	DEXXQc_Helz-like	611..847	CDD:350796	72/331 (22%)
		SF1_C_Upf1	848..1035	CDD:350195	59/199 (30%)
setx	XP_002936221.1	SEN1_N	38..>347	CDD:432746
		DEXXQc_SETX	1840..2157	CDD:438712	72/330 (22%)
		DNA2	<1946..2343	CDD:440729	107/427 (25%)
		PHA03247	<2365..2534	CDD:223021	40/198 (20%)