DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ITGA6 and mew

DIOPT Version :9

Sequence 1:NP_001381857.1 Gene:ITGA6 / 3655 HGNCID:6142 Length:1130 Species:Homo sapiens
Sequence 2:NP_001285196.1 Gene:mew / 32275 FlyBaseID:FBgn0004456 Length:1243 Species:Drosophila melanogaster


Alignment Length:1298 Identity:361/1298 - (27%)
Similarity:564/1298 - (43%) Gaps:336/1298 - (25%)


- Green bases have known domain annotations that are detailed below.


Human     8 CLLYLSAGLLSRLGAA-----FNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQ---PEDKRLLLV 64
            |.|..:.|:|..|...     |||:.|..  |.|||.|.|.||:|:|.|...:   |.....:||
  Fly    13 CRLRQNLGILIILQCVLTCYNFNLEQRLP--IVKYGHPHSHFGYSVATHTIGEANGPNKTNCVLV 75

Human    65 GAPRAEALPLQRANRT--GGLYSCDITAR-GPCTRI------EFDND--ADP-TSESKEDQWMGV 117
            |||..:.   ::.|.|  |.|:.|.:|.| ..|.::      .||::  :.| ..|.||||||||
  Fly    76 GAPLDQN---RQPNTTHSGALWRCPMTQRFDDCEQVITDGRRNFDSEILSPPGNDEIKEDQWMGV 137

Human   118 TV-----QSQGPGGKVVTCAHRYEKRQHVNTKQESRDIFGRCYVLSQNLRIEDDMDGGDWSFCDG 177
            ||     |:.|.||||:.|||||     :...:|:|...|.||:|:.:|:.|:..:.     |.|
  Fly   138 TVRSNPLQANGSGGKVIVCAHRY-----MYIVRENRYGQGLCYLLTNDLQFEEVHEP-----CKG 192

Human   178 R--LRGHEKFGSCQQGVAATFTKDFHYIVFGAPGTYNWKGIVRVEQKNNTFFDMNIFEDGPYEVG 240
            |  .|.||.:|.||.|.:|....| ..:|.|:||.|.|:|.:.|.|                 ||
  Fly   193 RPVQRQHEDYGLCQAGTSAALLDD-DTMVLGSPGPYTWRGSIWVTQ-----------------VG 239

Human   241 GETEHDESLVPVPANSYLGLLFLTSVSYTDPDQFVYKTRPPREQPDTFPDVMMNSYLGFSLDSGK 305
            ||                         |...|:..|.:    :..|....|...||||.|:..|:
  Fly   240 GE-------------------------YLQRDKTTYYS----DHSDLNSPVDKYSYLGMSVTGGR 275

Human   306 GIVSKDEITFVSGAPRANHSGAVVLLKRDMKSAHLLPEH-IFDGEGLASSFGYDVAVVDLNKDGW 369
            ..   ..:::.:||||:...|.||:.  |..:.:.:|.| |.|||...|||||::|..|:|.|..
  Fly   276 FF---GHMSYAAGAPRSEGHGQVVIF--DKSTDNPIPVHSILDGEQFGSSFGYELATADINGDHR 335

Human   370 QDIVIGAPQYFDRDGEVGGAVYVYMNQQGRWNNVKPIRLNGTKDSMFGIAVKNIGDINQDGYPDI 434
            .|:::.||.||.:  ..|||||||.|.|........::|.|..:|.||:|:.||||:|:|...|:
  Fly   336 PDLIVAAPLYFTK--TEGGAVYVYQNIQDTLPMKYTLKLTGPLESRFGLALANIGDLNKDNCEDL 398

Human   435 AVGAPYDDLGKVFIYHGSANGINTKPTQVLK-----GISP------YFGYSIAGNMDLDRNSYPD 488
            ||||||:..|.|:||.||:.|:|:||.|.::     |..|      .||.||:||.|||.|||||
  Fly   399 AVGAPYEGNGVVYIYLGSSQGLNSKPAQKIQASELGGTIPNGQPIRTFGISISGNTDLDDNSYPD 463

Human   489 VAVGSL-SDSVTIFRSRPVINIQKTI------TVTPNRIDLRQKTACGAPSGICLQVK----SCF 542
            |.:|:. |.:..|..:||:|:||.::      .:.||           .|.  ||...    :||
  Fly   464 VVIGAFNSSAAVILLARPIISIQTSVQRKELHNMDPN-----------TPG--CLDDPASNLTCF 515

Human   543 EYTA----NPAGY---NPSISIVGTLEAE---------------KERRKSGLSSRVQFRNQGSEP 585
            .:.|    .|  |   |..:.:..::|||               :|.:::.:.|||         
  Fly   516 TFRACCSIEP--YDEKNKELRLAYSVEAETFDHLKKFSRVFFFDRENKRTNVLSRV--------- 569

Human   586 KYTQELTLKRQKQKVCMEETLWLQDNIRDKLRPIPITASVEIQEP----SSRRRVNSLPEVLPIL 646
                 :.:....:..|...|.:::.|.||...|:.......:.||    |:..|:|      |||
  Fly   570 -----VRVHTNGRTECQAVTGYIKANTRDIQTPVRFRLKYSLVEPPLADSALVRLN------PIL 623

Human   647 NSDEPKTAHIDVH--FLKEGCGDDNVCNSNL--KLEYKFCTREGNQDKFSYLPIQKGVPELVLKD 707
            :..:   ||:|..  |.|: ||||::|.|||  ::|.......||:             ..::.|
  Fly   624 DQTQ---AHVDFEGTFQKD-CGDDDLCESNLIIRVEPNITESSGNE-------------YTLILD 671

Human   708 QKDIALEITVTNSPSNPRNPTKDGDDAHEAKLIATFPDTLTYSAYRELRAFPEKQLSCVANQ-NG 771
            :.::.:.|.|:|.          .|.|:||:|.......::|.|       .:|..:...|. |.
  Fly   672 ETELEVRINVSNL----------ADSAYEAQLFIAHQAGVSYVA-------TKKPTNATCNSYNT 719

Human   772 SQADCELGNPFKRNSNVTFYLVLSTTEVT--FDTPDLDINLKL-------ETTS--------NQD 819
            :...|.||||..|:         :||.||  |....|:.:.|:       .|||        .:|
  Fly   720 TLVACSLGNPMLRD---------TTTFVTIRFQPKGLEPSEKIMLFHIFANTTSKLVGPERPERD 775

Human   820 NLAPITAKAKVVIELLLSVSGVAKPSQVYFGGTVVGEQAMKSE------------DEVGSLIEYE 872
            ....:..:||      |:..|.|.|.|.::.|:.|......:.            |:|||.:.:.
  Fly   776 LRVNVVRRAK------LNFRGWAIPEQSFYSGSSVANSVANTAATDIEGHGPMGMDDVGSQVHHM 834

Human   873 FRVINLGKPLTNLGTATLNIQWPKEI----SNGK---WLLYLVKVESKGLEKVTCEPQKE-INSL 929
            |.:.|.| |.| .....:.|.||..:    .:|:   :||||.:|.:..:.:..|...|| :|.|
  Fly   835 FTIFNEG-PST-APKVQMVIHWPYSLYSDPQSGRPVQYLLYLEQVPTVEVSQGECHVAKEYVNPL 897

Human   930 NL---------------------------------------------------TESHNSRKKREI 943
            ||                                                   |:|:.:|.:|..
  Fly   898 NLASGSRENPAYLSAPAQMRMFPSQSRHSFNKSLIHSQRSYYSSSHRDDHSDDTQSNRNRVRRSF 962

Human   944 TEK-----QIDDNRKFSLFAERKYQ---TLNCSVN-VNCVNIRCPLRGLD--SKASLILRSRLWN 997
            .|:     ::..:.:.|..|..|.|   .|:|:.. .|||.|.|.:..:.  |:|.:::::||||
  Fly   963 LERVTRLERLMYDPESSNAANGKKQDIVELDCNKGATNCVRIECDILNMPALSEAQVVVKARLWN 1027

Human   998 STFLEEYSKLNYLDILMRAFIDVTAAAENIRLPNAGTQVRVTVFPS-KTVAQYSGVPWWIILVAI 1061
            ||.:.||.::..:.|...|...:..:.....:.:...:|....:|. :...:.:.:||.||::.|
  Fly  1028 STLVSEYPRVERVRIFSTATAQIPESYGVEVMDHNNIEVETRAYPELRNQQRDTSIPWLIIILGI 1092

Human  1062 LAGILMLALLVFILWKCGFFKRSRYDDSVPRYHAVRIRKEEREIKDEKYIDNLEKKQWITKWN 1124
            :.|:|:|||:.::|||.|||||.|..|.....:..::.:|:..:...|...::. ::....|:
  Fly  1093 VGGLLLLALVTYVLWKVGFFKRIRPTDPTLSGNLEKMNEEKPFLAPSKNTHHVFXQEGTVGWD 1155

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ITGA6NP_001381857.1 FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 30..95 24/70 (34%)
FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 101..166 31/72 (43%)
FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 176..229 20/54 (37%)
FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 283..339 16/55 (29%)
FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 340..402 29/62 (47%)
FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 403..458 26/54 (48%)
FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 459..518 28/76 (37%)
Interaction with HPS5 1077..1083 4/5 (80%)
GFFKR motif 1079..1083 3/3 (100%)
mewNP_001285196.1 Int_alpha 48..111 CDD:214549 21/65 (32%)
Int_alpha 317..368 CDD:214549 23/52 (44%)
Int_alpha 378..428 CDD:214549 28/49 (57%)
Int_alpha 446..491 CDD:214549 23/44 (52%)
Integrin_alpha2 479..1006 CDD:285619 133/612 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 123 1.000 Domainoid score I5581
eggNOG 1 0.900 - - E1_KOG3637
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H20091
Inparanoid 1 1.050 377 1.000 Inparanoid score I2089
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG46425
OrthoDB 1 1.010 - - D325432at33208
OrthoFinder 1 1.000 - - FOG0001200
OrthoInspector 1 1.000 - - otm41582
orthoMCL 1 0.900 - - OOG6_102503
Panther 1 1.100 - - O PTHR23220
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2587
SonicParanoid 1 1.000 - - X929
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.870

Return to query results.
Submit another query.