DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PheRS-m and fars2

DIOPT Version :9

Sequence 1:	NP_477283.1	Gene:	PheRS-m / 36547	FlyBaseID:	FBgn0275436	Length:	453	Species:	Drosophila melanogaster
Sequence 2:	NP_001099064.1	Gene:	fars2 / 793097	ZFINID:	ZDB-GENE-070928-38	Length:	449	Species:	Danio rerio

Alignment Length:	440	Identity:	221/440 - (50%)
Similarity:	298/440 - (67%)	Gaps:	23/440 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 TRCLASSAAPAKSPSSPPQLEVSGSTYATDGWTNVTPKILSYVGANKHLQTDHPLSIIRQRIVNY 81
            :|||::..:..:.......:::....|..|..||||.||||.||...|.:..|||.:|::||.::
Zfish    29 SRCLSTDGSAEQPQIQENSVQLFNHVYPRDDMTNVTAKILSKVGCQLHNRPHHPLWLIKERIKDH 93

  Fly    82 FYGAYRNQRGNPLFSVYDQMNPVVTVQQNFDNLLIPADHVSRQKSDCYYINQQHLLRAHTTAHQV 146
            ||.:|..:.|||:|||:|.:.|||||:||||:|||||||.|.:|.:.||:|:.|:|||||:|||.
Zfish    94 FYRSYVGRTGNPIFSVHDNLRPVVTVEQNFDSLLIPADHPSCKKGENYYLNRTHMLRAHTSAHQK 158

  Fly   147 ELISGGLDNFLVVGEVYRRDEIDSTHYPVFHQADAVRLVTKDKLF---ERNPGLELFEETWSGTL 208
            ||:..|||.||:.|:||||||:||:|||||||.:.|||.:..:||   |....|.|||.   |..
Zfish   159 ELVRSGLDCFLLAGDVYRRDEVDSSHYPVFHQMEGVRLFSNHELFAGVENGEDLSLFER---GGR 220

  Fly   209 ADPKLILPSSKFMDQTKQPCHTLEAVKLMEHEMKHVLVGLTKDLFGPRIKYRWVDTYFPFTQPSW 273
            ..|:            ||..||||||||:|.::|..|..|.:.|||..::.||||.|||||.||:
Zfish   221 RTPQ------------KQETHTLEAVKLLEFDLKRALTRLVRHLFGEDLEIRWVDCYFPFTHPSF 273

  Fly   274 ELEIYFKDNWLEVLGCGIMRHEILQRSGVHQSIGYAFGVGLERLAMVLFDIPDIRLFWSNDSGFL 338
            |:|::|:.:|:||||||:|..|:::.:|....:|:|||:||||||||||.|||||||||.|..||
Zfish   274 EMEVFFQGDWMEVLGCGVMEQELVRSAGADNKMGWAFGLGLERLAMVLFGIPDIRLFWSEDERFL 338

  Fly   339 SQFSEKDLHNLPKYKPISHYPQCTNDLSFWLPQDIEVDAGFSPNDFYDLVRSVAGDMVEQISLVD 403
            .||...|::....::|:|.||...||:|||||.:     |::.|||:|||||:.||:||:::|||
Zfish   339 KQFRLSDIYQPVTFQPLSKYPPLFNDISFWLPAE-----GYTENDFFDLVRSIGGDLVEKVTLVD 398

  Fly   404 KFKHPKTGKSSVCFRIVYRHMERTLTQAEVNEIHKQIASASVDSFNVQIR 453
            .|.|||..|.|.|:|:|||||||||||.||:.:|..|.:|......||.|
Zfish   399 TFTHPKMKKVSHCYRLVYRHMERTLTQEEVSIVHTAIQTAVEQELGVQGR 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PheRS-m	NP_477283.1	pheS_mito	29..452	CDD:129561	216/425 (51%)
		PheRS_alpha_core	69..334	CDD:238277	145/267 (54%)
		FDX-ACB	356..453	CDD:214893	52/96 (54%)
fars2	NP_001099064.1	PLN02788	54..448	CDD:215422	217/413 (53%)
		PheRS_alpha_core	81..336	CDD:238277	146/269 (54%)
		FDX-ACB	356..448	CDD:214893	52/96 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581341
Domainoid	1	1.000	136	1.000	Domainoid score	I4902
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4788
Inparanoid	1	1.050	453	1.000	Inparanoid score	I1568
OMA	1	1.010	-	-		QHG54668
OrthoDB	1	1.010	-	-		D1115196at2759
OrthoFinder	1	1.000	-	-		FOG0003716
OrthoInspector	1	1.000	-	-		oto40549
orthoMCL	1	0.900	-	-		OOG6_102538
Panther	1	1.100	-	-	LDO	PTHR11538
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1439
SonicParanoid	1	1.000	-	-		X3075
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940