DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PheRS-m and Fars2

DIOPT Version :9

Sequence 1:	NP_477283.1	Gene:	PheRS-m / 36547	FlyBaseID:	FBgn0275436	Length:	453	Species:	Drosophila melanogaster
Sequence 2:	NP_077236.1	Gene:	Fars2 / 69955	MGIID:	1917205	Length:	451	Species:	Mus musculus

Alignment Length:	446	Identity:	229/446 - (51%)
Similarity:	303/446 - (67%)	Gaps:	28/446 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 RHWLKSTRCLASSAAPAKSPSSPPQLEVSGSTYATDGWTNVTPKILSYVGANKHLQTDHPLSIIR 75
            |.|  |::..||.:|...:|.|  .||:.|.:|..|..||:|.|:||.||.|.|.|..|||.:|:
Mouse    30 RAW--SSKPAASQSAVQGAPGS--VLEILGKSYPQDDHTNLTQKVLSKVGRNLHNQKFHPLWLIK 90

  Fly    76 QRIVNYFYGAYRNQRGNPLFSVYDQMNPVVTVQQNFDNLLIPADHVSRQKSDCYYINQQHLLRAH 140
            :|:..:||..|..:...||||||||:.||||..||||:|||||||.||:|.|.||:|:.|:||||
Mouse    91 ERVKEHFYQQYMVRSRTPLFSVYDQLPPVVTTWQNFDSLLIPADHPSRKKGDNYYLNRAHMLRAH 155

  Fly   141 TTAHQVELISGGLDNFLVVGEVYRRDEIDSTHYPVFHQADAVRLVTKDKLF---ERNPGLELFEE 202
            |:|||.:|:..||:.|||||:|||||:||..|||||||.:.|||.:|.:||   :....|:||||
Mouse   156 TSAHQWDLLHAGLNAFLVVGDVYRRDQIDCQHYPVFHQLEGVRLFSKHELFAGVKDGESLQLFEE 220

  Fly   203 TWSGTLADPKLILPSSKFMDQTKQPCHTLEAVKLMEHEMKHVLVGLTKDLFGPRIKYRWVDTYFP 267
               |:             ....||..||:|||||:|.::|.||..|...|||..::.||||.|||
Mouse   221 ---GS-------------RSAHKQETHTMEAVKLVEFDLKQVLTRLVTHLFGDGLEVRWVDCYFP 269

  Fly   268 FTQPSWELEIYFKDNWLEVLGCGIMRHEILQRSGVHQSIGYAFGVGLERLAMVLFDIPDIRLFWS 332
            ||.||:|:||.|:..||||||||:|..:::..:|....||:|||:|||||||||:||||||||||
Mouse   270 FTHPSFEMEINFRGEWLEVLGCGVMEQQLVNSAGAQDRIGWAFGLGLERLAMVLYDIPDIRLFWS 334

  Fly   333 NDSGFLSQFSEKDLHNLPKYKPISHYPQCTNDLSFWLPQDIEVDAGFSPNDFYDLVRSVAGDMVE 397
            .|..||.||...|::...|::|:|.||...||:|||||.:     .::.|||||:||:|.||:||
Mouse   335 EDERFLKQFLLSDINQSVKFQPLSKYPAVFNDISFWLPSE-----NYTENDFYDIVRTVGGDLVE 394

  Fly   398 QISLVDKFKHPKTGKSSVCFRIVYRHMERTLTQAEVNEIHKQIASASVDSFNVQIR 453
            ::.|:|||:||||.::|.|:||.||||||||:|.||..:|:.:..|:|....|:.|
Mouse   395 KVDLIDKFEHPKTHRTSHCYRITYRHMERTLSQREVGNVHQAVQEAAVQLLGVEGR 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PheRS-m	NP_477283.1	pheS_mito	29..452	CDD:129561	222/425 (52%)
		PheRS_alpha_core	69..334	CDD:238277	147/267 (55%)
		FDX-ACB	356..453	CDD:214893	49/96 (51%)
Fars2	NP_077236.1	PLN02788	32..450	CDD:215422	227/442 (51%)
		Substrate binding. /evidence=ECO:0000250	157..160		1/2 (50%)
		Substrate binding. /evidence=ECO:0000250	186..188		0/1 (0%)
		Substrate binding. /evidence=ECO:0000250	193..195		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837637
Domainoid	1	1.000	137	1.000	Domainoid score	I4878
eggNOG	1	0.900	-	-		E1_COG0016
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4788
Inparanoid	1	1.050	451	1.000	Inparanoid score	I1597
Isobase	1	0.950	-	0	Normalized mean entropy	S935
OMA	1	1.010	-	-		QHG54668
OrthoDB	1	1.010	-	-		D1115196at2759
OrthoFinder	1	1.000	-	-		FOG0003716
OrthoInspector	1	1.000	-	-		oto94617
orthoMCL	1	0.900	-	-		OOG6_102538
Panther	1	1.100	-	-	LDO	PTHR11538
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1439
SonicParanoid	1	1.000	-	-		X3075
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750