DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PheRS-m and Farsa

DIOPT Version :9

Sequence 1:	NP_477283.1	Gene:	PheRS-m / 36547	FlyBaseID:	FBgn0275436	Length:	453	Species:	Drosophila melanogaster
Sequence 2:	NP_079924.2	Gene:	Farsa / 66590	MGIID:	1913840	Length:	508	Species:	Mus musculus

Alignment Length:	371	Identity:	81/371 - (21%)
Similarity:	135/371 - (36%)	Gaps:	122/371 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 HWLKSTRCLASSAAPAKSPSSPPQLEVSGSTYATDGWTN--VTPKILSYVGA---NKHLQTDHPL 71
            :|:...:..::|.:..::..||..:. |||      |.:  ..|...|..|.   :.||   |||
Mouse   173 YWVSKGKAFSTSVSKQEAELSPEMIS-SGS------WRDRPFKPYNFSARGVLPDSGHL---HPL 227

  Fly    72 SIIRQRIVNYFYGAYRNQRGNPLFSVYDQMNPVVTVQQNFDNLLIPADHVSRQKSDCYYIN---- 132
            ..:|.:....|.     :.|   |:.....|.:.:...|||.|..|..|.:|.:.|.:::.
Mouse   228 LKVRSQFRQIFL-----EMG---FTEMPTDNFIESSFWNFDALFQPQQHPARDQHDTFFLRDPAE 284

  Fly   133 -----------------------------------QQHLLRAHTTAHQVELISGGLD-------N 155
                                               :::|||.||||.....:.....       .
Mouse   285 ALQLPMGYVQRVKRTHSQGGYGSQGYKYTWKLEEARKNLLRTHTTAASARALYQLAQKKPFTPAK 349

  Fly   156 FLVVGEVYRRDEIDSTHYPVFHQADAVRLVTKDKLFERNPGLELFEETWSGTLADPKLILPSSKF 220
            :..:..|:|.:.:|:||...|||.:                         |.:||..|.|.
Mouse   350 YFSIDRVFRNETLDATHLAEFHQIE-------------------------GVIADHGLTLG---- 385

  Fly   221 MDQTKQPCHTLEAVKLMEHEMKHVLVGLTKDLFGPRIKYRWVDTYFPFTQPSWELEIYFK--DNW 283
                    |.:..  |.|...|   :|:|:..|.|        .|.|:|:||.|:..|.:  ..|
Mouse   386 --------HLMGV--LREFFTK---LGITQLRFKP--------AYNPYTEPSMEVFSYHQGLKKW 429

  Fly   284 LEVLGCGIMRHEILQRSGVHQSIG-YAFGVGLERLAMVLFDIPDIR 328
            :||...|:.|.|:|...|:.:::. .|:|:.|||..|:.:.|.:||
Mouse   430 VEVGNSGVFRPEMLLPMGLPENVSVIAWGLSLERPTMIKYGINNIR 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PheRS-m	NP_477283.1	pheS_mito	29..452	CDD:129561	79/354 (22%)
		PheRS_alpha_core	69..334	CDD:238277	68/309 (22%)
		FDX-ACB	356..453	CDD:214893
Farsa	NP_079924.2	PLN02853	22..497	CDD:215458	81/371 (22%)
		tRNA-synt_2d	209..482	CDD:279717	73/328 (22%)
		L-phenylalanine binding. /evidence=ECO:0000250\|UniProtKB:Q9Y285	372..374		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0016
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810