DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PheRS-m and SPCC736.03c

DIOPT Version :9

Sequence 1:	NP_477283.1	Gene:	PheRS-m / 36547	FlyBaseID:	FBgn0275436	Length:	453	Species:	Drosophila melanogaster
Sequence 2:	NP_587774.1	Gene:	SPCC736.03c / 2538914	PomBaseID:	SPCC736.03c	Length:	429	Species:	Schizosaccharomyces pombe

Alignment Length:	434	Identity:	164/434 - (37%)
Similarity:	250/434 - (57%)	Gaps:	55/434 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 TDGWTNVTPKILSYVGANKHLQTDHPLSIIRQRIVNYFYGAYRNQRGNPLFSVYDQMNPVVTVQQ 109
            ||.|:||...|.|.:|.|...:..||:..:||.:...|.....|.        ..:.:|:|:|:.
pombe    26 TDSWSNVPEHIHSKIGRNLFQKEGHPICSLRQLLEQQFQKFEMNN--------VQKESPIVSVET 82

  Fly   110 NFDNLLIPADHVSRQKSDCYYINQQHLLRAHTTAHQVE----LISGGL--DNFLVVGEVYRRDEI 168
            |||:|..|..||||.|||.||:|.:..||.||:|||.|    |...|.  :.||:..:||||||:
pombe    83 NFDSLGFPKTHVSRSKSDTYYMNNKTCLRTHTSAHQPEEFSRLAKEGFKKNGFLITADVYRRDEV 147

  Fly   169 DSTHYPVFHQADAVRLVTKDKLFERNPGLELFEETWSGTLADPKLILPSSKFM--DQT------- 224
            ||:|||:|||.:..      .::.||...::..:.....|:      ||.|.|  |:|
pombe   148 DSSHYPIFHQMEGA------LVWNRNDTAKMKNDLKKVALS------PSLKSMVDDETTALETHN 200

  Fly   225 -KQPCHTLEAVKLMEHEMKHVLVGLTKDLF---------GPRIKYRWVDTYFPFTQPSWELEIYF 279
             .|..::||..|.:...:|..|..:..||.         ..:::|||....||||:||::|||.:
pombe   201 DMQDIYSLEETKFVSQHLKDTLTTVIHDLVSLAPSISSGAEQVRYRWTYDSFPFTKPSFQLEIDW 265

  Fly   280 KDNWLEVLGCGIMRHEILQRSGVHQSIGYAFGVGLERLAMVLFDIPDIRLFWSNDSGFLSQFSEK 344
            |..|||:||||:::..:|:.:|::..||:|||:|||||||:|:.|||||||||.|..|..||..
pombe   266 KGKWLEILGCGVVQDRLLKGAGLNNYIGWAFGIGLERLAMILYGIPDIRLFWSLDERFSKQFLP- 329

  Fly   345 DLHNLPKYKPISHYPQCTNDLSFWLPQDIEVDAGFSPNDFYDLVRSVAGDMVEQISLVDKFKHPK 409
              :.:..:||.|.||.|..|::||:..|      |:|||||:::|.|..||||.::|:|::. .|
pombe   330 --NKISTFKPFSKYPACFKDIAFWINND------FNPNDFYEIIRDVCQDMVESVNLIDQYT-AK 385

  Fly   410 TGKSSVCFRIVYRHMERTLTQAEVNEIHKQIASASVDSFNVQIR 453
            :||:|:|:|:.||.|||:|...|::::.:::.:...:|..|::|
pombe   386 SGKTSLCYRVNYRSMERSLRNEEIDKLQEKLRNRVANSLRVELR 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PheRS-m	NP_477283.1	pheS_mito	29..452	CDD:129561	163/431 (38%)
		PheRS_alpha_core	69..334	CDD:238277	111/289 (38%)
		FDX-ACB	356..453	CDD:214893	37/96 (39%)
SPCC736.03c	NP_587774.1	pheS_mito	23..428	CDD:129561	163/431 (38%)
		PheRS_alpha_core	50..322	CDD:238277	112/291 (38%)
		FDX-ACB	339..429	CDD:214893	37/96 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	113	1.000	Domainoid score	I1564
eggNOG	1	0.900	-	-		E1_COG0016
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4788
Inparanoid	1	1.050	297	1.000	Inparanoid score	I614
OMA	1	1.010	-	-		QHG54668
OrthoFinder	1	1.000	-	-		FOG0003716
OrthoInspector	1	1.000	-	-		oto101793
orthoMCL	1	0.900	-	-		OOG6_102538
Panther	1	1.100	-	-	LDO	PTHR11538
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1439
SonicParanoid	1	1.000	-	-		X3075
TreeFam	1	0.960	-	-
	13	12.950