DRSC/TRiP Functional Genomics Resources

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Protein Alignment PheRS-m and FARSA

DIOPT Version :9

Sequence 1:NP_477283.1 Gene:PheRS-m / 36547 FlyBaseID:FBgn0275436 Length:453 Species:Drosophila melanogaster
Sequence 2:NP_004452.1 Gene:FARSA / 2193 HGNCID:3592 Length:508 Species:Homo sapiens


Alignment Length:380 Identity:80/380 - (21%)
Similarity:139/380 - (36%) Gaps:126/380 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 LTLRVQGARHWLKSTRCLASSAAPAKSPSSPPQLEVSGSTYATDGWTNVTPKILSYVG-----AN 62
            :||:.    :|:......::|.:..::..||..:. |||      |.:...|..:::.     .:
Human   168 VTLKT----YWVSKGSAFSTSISKQETELSPEMIS-SGS------WRDRPFKPYNFLAHGVLPDS 221

  Fly    63 KHLQTDHPLSIIRQRIVNYFYGAYRNQRGNPLFSVYDQMNPVVTVQQNFDNLLIPADHVSRQKSD 127
            .||   |||..:|.:....|.     :.|   |:.....|.:.:...|||.|..|..|.:|.:.|
Human   222 GHL---HPLLKVRSQFRQIFL-----EMG---FTEMPTDNFIESSFWNFDALFQPQQHPARDQHD 275

  Fly   128 CYYIN---------------------------------------QQHLLRAHTTAHQVELISGGL 153
            .:::.                                       :::|||.|||:.....:....
Human   276 TFFLRDPAEALQLPMDYVQRVKRTHSQGGYGSQGYKYNWKLDEARKNLLRTHTTSASARALYRLA 340

  Fly   154 D-------NFLVVGEVYRRDEIDSTHYPVFHQADAVRLVTKDKLFERNPGLELFEETWSGTLADP 211
            .       .:..:..|:|.:.:|:||...|||.:                         |.:||.
Human   341 QKKPFTPVKYFSIDRVFRNETLDATHLAEFHQIE-------------------------GVVADH 380

  Fly   212 KLILPSSKFMDQTKQPCHTLEAVKLMEHEMKHVLVGLTKDLFGPRIKYRWVDTYFPFTQPSWELE 276
            .|.|.            |.:..  |.|...|   :|:|:..|.|        .|.|:|:||.|:.
Human   381 GLTLG------------HLMGV--LREFFTK---LGITQLRFKP--------AYNPYTEPSMEVF 420

  Fly   277 IYFK--DNWLEVLGCGIMRHEILQRSGVHQSIG-YAFGVGLERLAMVLFDIPDIR 328
            .|.:  ..|:||...|:.|.|:|...|:.:::. .|:|:.|||..|:.:.|.:||
Human   421 SYHQGLKKWVEVGNSGVFRPEMLLPMGLPENVSVIAWGLSLERPTMIKYGINNIR 475

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PheRS-mNP_477283.1 pheS_mito 29..452 CDD:129561 76/354 (21%)
PheRS_alpha_core 69..334 CDD:238277 67/309 (22%)
FDX-ACB 356..453 CDD:214893
FARSANP_004452.1 PTZ00326 1..484 CDD:240361 80/380 (21%)
L-phenylalanine binding. /evidence=ECO:0000269|PubMed:20223217, ECO:0007744|PDB:3L4G 372..374 1/1 (100%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0016
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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