DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PheRS-m and fars2

DIOPT Version :9

Sequence 1:	NP_477283.1	Gene:	PheRS-m / 36547	FlyBaseID:	FBgn0275436	Length:	453	Species:	Drosophila melanogaster
Sequence 2:	XP_031759688.1	Gene:	fars2 / 100491109	XenbaseID:	XB-GENE-944560	Length:	479	Species:	Xenopus tropicalis

Alignment Length:	430	Identity:	227/430 - (52%)
Similarity:	294/430 - (68%)	Gaps:	27/430 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 PSSP---PQLEVSGSTYATDGWTNVTPKILSYVGANKHLQTDHPLSIIRQRIVNYFYGAYRNQRG 91
            |||.   ..:::.||.|..|.:||||.||||.||.|.|.|..|||.:|::||.::||..|..:.|
Frog    70 PSSTNIHNHVQLLGSLYPRDDYTNVTSKILSKVGKNLHNQKYHPLWLIKERIKDHFYKEYVGRFG 134

  Fly    92 NPLFSVYDQMNPVVTVQQNFDNLLIPADHVSRQKSDCYYINQQHLLRAHTTAHQVELISGGLDNF 156
            ||||||:|.::||||.:||||.||||.||.||:|.|.||:|:.|:|||||:|||.:|::.|||.|
Frog   135 NPLFSVFDNLSPVVTTEQNFDRLLIPLDHPSRKKGDNYYLNRYHMLRAHTSAHQWDLMNSGLDAF 199

  Fly   157 LVVGEVYRRDEIDSTHYPVFHQADAVRLVTKDKLF---ERNPGLELFEETWSGTLADPKLILPSS 218
            |.||:||||||||.:|||.|||.:.|.|.:...||   |......|||                :
Frog   200 LAVGDVYRRDEIDRSHYPAFHQMEGVCLFSNHTLFAEVECKDSCHLFE----------------N 248

  Fly   219 KFMDQTKQPCHTLEAVKLMEHEMKHVLVGLTKDLFGPRIKYRWVDTYFPFTQPSWELEIYFKDNW 283
            .|....||..||||||||:|..:|..|..|...|||..::.||||.|||||.||:|:||.|:..|
Frog   249 GFRTTNKQESHTLEAVKLVEFRLKQTLSKLIAHLFGEGLEIRWVDCYFPFTHPSFEMEIKFQGEW 313

  Fly   284 LEVLGCGIMRHEILQRSGVHQSIGYAFGVGLERLAMVLFDIPDIRLFWSNDSGFLSQFSEKDLHN 348
            :||||||:|..:|:..:|.|..||:|||:|||||||:|:.|||||||||.:..||.||...|::.
Frog   314 MEVLGCGVMEQQIVNSAGAHNKIGWAFGLGLERLAMILYGIPDIRLFWSENELFLKQFQVADINQ 378

  Fly   349 LPKYKPISHYPQCTNDLSFWLPQDIEVDAGFSPNDFYDLVRSVAGDMVEQISLVDKFKHPKTGKS 413
            ...::|:|.||..|||:|||||::     |:|.|||||||||:.||:||:::|||:||||||.|:
Frog   379 QITFQPLSKYPCLTNDISFWLPEE-----GYSENDFYDLVRSIGGDLVEKVTLVDQFKHPKTQKT 438

  Fly   414 SVCFRIVYRHMERTLTQAEVNEIHKQIASASVDSFNVQIR 453
            |.|:|||||||||||:|.|:|.:||.|..::|....|:.|
Frog   439 SHCYRIVYRHMERTLSQMEINVLHKNIEQSAVQELGVEGR 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PheRS-m	NP_477283.1	pheS_mito	29..452	CDD:129561	226/427 (53%)
		PheRS_alpha_core	69..334	CDD:238277	143/267 (54%)
		FDX-ACB	356..453	CDD:214893	57/96 (59%)
fars2	XP_031759688.1	PLN02788	79..478	CDD:215422	223/419 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	131	1.000	Domainoid score	I5124
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4788
Inparanoid	1	1.050	453	1.000	Inparanoid score	I1563
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1115196at2759
OrthoFinder	1	1.000	-	-		FOG0003716
OrthoInspector	1	1.000	-	-		oto104814
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3075
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060