Protein Alignment CtsL1 and CTSF

DIOPT Version :10

• Sequence 1: NP_523735.2
• Gene: CtsL1 / 36546
• FlyBaseID: FBgn0013770
• Length: 371
• Species: Drosophila melanogaster
• Sequence 2: NP_003784.2
• Gene: CTSF / 8722
• HGNCID: 2531
• Length: 484
• Species: Homo sapiens
• Alignment Length: 338
• Identity: 129/338 - (38%)
• Similarity: 181/338 - (53%)
• Gaps: 32/338 - (9%)

  Fly    38 PLLALLAVAQAVSFADVVMEEWHTFKLEHRKNYQDETEERFRLKIFNENKHKIAKHNQRFAEGKV 102
            ||...|.|..|..|.:        |.:.:.:.|:.:.|.|:||.:|..|..: |:..|....|..
Human   174 PLSQDLPVKMASIFKN--------FVITYNRTYESKEEARWRLSVFVNNMVR-AQKIQALDRGTA 229

  Fly   103 SFKLAVNKYADLLHHEFRQLMNGFNYTLHKQLRAADESFKGVTFISPAHVTLPKSVDWRTKGAVT 167
            .:  .|.|::||...|||.:.  .|..|.|:.....:..|.|..::      |...|||:|||||
Human   230 QY--GVTKFSDLTEEEFRTIY--LNTLLRKEPGNKMKQAKSVGDLA------PPEWDWRSKGAVT 284

  Fly   168 AVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKD 232
            .|||||.||||||||.||.:|||.|...|.|:|||||.|:||...  :..|.|||..||:..||:
Human   285 KVKDQGMCGSCWAFSVTGNVEGQWFLNQGTLLSLSEQELLDCDKM--DKACMGGLPSNAYSAIKN 347

  Fly   233 NGGIDTEKSYPYEAIDDSCHFN--KGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHE 295
            .||::||..|.|:....||:|:  |..|...|.  .::.| :|:|:|..:|..||:||||:|.
Human   348 LGGLETEDDYSYQGHMQSCNFSAEKAKVYINDS--VELSQ-NEQKLAAWLAKRGPISVAINAF-- 407

  Fly   296 SFQFYSEGVYN--EPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKEN 358
            ..|||..|:..  .|.|....:||.||:||:| :.|...:|.:||||||.||:||:..:.|. ..
Human   408 GMQFYRHGISRPLRPLCSPWLIDHAVLLVGYG-NRSDVPFWAIKNSWGTDWGEKGYYYLHRG-SG 470

  Fly   359 QCGIASASSYPLV 371
            .||:.:.:|..:|
Human   471 ACGVNTMASSAVV 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CtsL1	NP_523735.2	Inhibitor_I29	59..118	CDD:214853	15/58 (26%)
		Peptidase_C1	154..370	CDD:425470	99/219 (45%)
CTSF	NP_003784.2	Inhibitor_I29	187..243	CDD:214853	16/66 (24%)
		Peptidase_C1	271..482	CDD:425470	99/225 (44%)