DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cp1 and Ctsll3

DIOPT Version :9

Sequence 1:	NP_523735.2	Gene:	Cp1 / 36546	FlyBaseID:	FBgn0013770	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	NP_081620.2	Gene:	Ctsll3 / 70202	MGIID:	1917452	Length:	331	Species:	Mus musculus

Alignment Length:	346	Identity:	174/346 - (50%)
Similarity:	218/346 - (63%)	Gaps:	20/346 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 MRTAVLLPLLALLAVAQAVSF---ADVVMEEWHTFKLEHRKNY--QDETEERFRLKIFNENKHKI 90
            |....||..|.|..|:.|.:.   .|.|.|||   |.:|:|.|  .||.::|   .::..||..|
Mouse     1 MTPVFLLATLCLGVVSAAPAHNPSLDAVWEEW---KTKHKKTYNMNDEGQKR---AVWENNKKMI 59

  Fly    91 AKHNQRFAEGKVSFKLAVNKYADLLHHEFRQLMNGFNYTLHKQLRAADESFKGVTFISPAHVTLP 155
            ..||:.:.:||..|.|.:|.:.||.:.|||:||.||.....|.:..        .|..|....:|
Mouse    60 DLHNEDYLKGKHGFSLEMNAFGDLTNTEFRELMTGFQGQKTKMMMK--------VFQEPLLGDVP 116

  Fly   156 KSVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNG 220
            ||||||..|.||.|||||.||||||||:.|:||||.|||:|.||.||.|||||||...||.||:|
Mouse   117 KSVDWRDHGYVTPVKDQGSCGSCWAFSAVGSLEGQMFRKTGKLVPLSVQNLVDCSWSQGNQGCDG 181

  Fly   221 GLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGP 285
            ||.|.||:|:|||||:||..||||||::.:|.:|.....||..||.:: |..|..:.:|||||||
Mouse   182 GLPDLAFQYVKDNGGLDTSVSYPYEALNGTCRYNPKNSAATVTGFVNV-QSSEDALMKAVATVGP 245

  Fly   286 VSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFI 350
            :||.||..|:|||||.||:|.||.|.:..|||.|||||:|.:..|..|||||||||..||..|:|
Mouse   246 ISVGIDTKHKSFQFYKEGMYYEPDCSSTVLDHAVLVVGYGEESDGRKYWLVKNSWGRDWGMNGYI 310

  Fly   351 KMLRNKENQCGIASASSYPLV 371
            ||.:::.|.|||||.:|||:|
Mouse   311 KMAKDRNNNCGIASDASYPVV 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cp1	NP_523735.2	Inhibitor_I29	59..118	CDD:214853	20/60 (33%)
Cp1	NP_523735.2	Peptidase_C1	154..370	CDD:278538	131/215 (61%)
Ctsll3	NP_081620.2	PTZ00203	7..330	CDD:185513	170/337 (50%)
		Inhibitor_I29	29..87	CDD:214853	22/63 (35%)
		Peptidase_C1	115..330	CDD:278538	131/215 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	303	1.000	Domainoid score	I1389
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	366	1.000	Inparanoid score	I2141
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53545
OrthoDB	1	1.010	-	-		D1275401at2759
OrthoFinder	1	1.000	-	-		FOG0000114
OrthoInspector	1	1.000	-	-		otm42924
orthoMCL	1	0.900	-	-		OOG6_100116
Panther	1	1.100	-	-	O	PTHR12411
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X64
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.880