DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cp1 and Ctsb

DIOPT Version :9

Sequence 1:	NP_523735.2	Gene:	Cp1 / 36546	FlyBaseID:	FBgn0013770	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	NP_072119.2	Gene:	Ctsb / 64529	RGDID:	621509	Length:	339	Species:	Rattus norvegicus

Alignment Length:	260	Identity:	81/260 - (31%)
Similarity:	107/260 - (41%)	Gaps:	61/260 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 VTLPKSVD----WRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFR-----KSGVLVSLSEQNLV 207
            :.||:|.|    |.....:..::|||.|||||||   ||:|....|     ...|.|.:|.::|:
  Rat    78 INLPESFDAREQWSNCPTIAQIRDQGSCGSCWAF---GAVEAMSDRICIHTNGRVNVEVSAEDLL 139

  Fly   208 DCSTKYGNNGCNGGLMDNAFRYIKD----NGGI------------------------------DT 238
            .|......:|||||....|:.:...    :||:                              ||
  Rat   140 TCCGIQCGDGCNGGYPSGAWNFWTRKGLVSGGVYNSHIGCLPYTIPPCEHHVNGSRPPCTGEGDT 204

  Fly   239 EKSYPYEAIDDSCHFNKGTVGATDR--GFTDIPQGDEKK--MAEAVATVGPVSVAIDASHESFQF 299
            .|      .:..|.....|....|:  |:|.....|.:|  ||| :...|||..|... ...|..
  Rat   205 PK------CNKMCEAGYSTSYKEDKHYGYTSYSVSDSEKEIMAE-IYKNGPVEGAFTV-FSDFLT 261

  Fly   300 YSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIAS 364
            |..|||.....|... .|.:.::|:|. |:|..||||.|||...|||.||.|:||. ||.|||.|
  Rat   262 YKSGVYKHEAGDVMG-GHAIRILGWGI-ENGVPYWLVANSWNVDWGDNGFFKILRG-ENHCGIES 323

Fly 365 364
Rat 324 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cp1	NP_523735.2	Inhibitor_I29	59..118	CDD:214853
Cp1	NP_523735.2	Peptidase_C1	154..370	CDD:278538	81/258 (31%)
Ctsb	NP_072119.2	Propeptide_C1	26..65	CDD:285358
Ctsb	NP_072119.2	Peptidase_C1A_CathepsinB	81..328	CDD:239111	80/257 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53545
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820