DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cp1 and ctsf

DIOPT Version :9

Sequence 1:	NP_523735.2	Gene:	Cp1 / 36546	FlyBaseID:	FBgn0013770	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	NP_001071036.1	Gene:	ctsf / 565588	ZFINID:	ZDB-GENE-030131-9831	Length:	473	Species:	Danio rerio

Alignment Length:	346	Identity:	124/346 - (35%)
Similarity:	190/346 - (54%)	Gaps:	29/346 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 MRTAVLLPLLALLAVAQAVSFADVVMEEWHTFKLEHRKNYQDETEERFRLKIFNENKHKIAKHNQ 95
            ::....:||.....:.::|.    ::..:..|.:.:.:.|..:.|...||:||.:|. |.|:..|
Zfish   151 LKKVAAVPLTHSKPMKESVE----LLTMFKNFMITYNRTYSSQEEAEKRLRIFQQNM-KTAQTLQ 210

  Fly    96 RFAEGKVSFKLAVNKYADLLHHEFRQL-MNGF--NYTLHKQLRAADESFKGVTFISPAHVTLPKS 157
            ...:|...:  .:.|::||...|||.: :|..  .::|.|:::.|          .||....|.:
Zfish   211 SLEQGSAEY--GITKFSDLTEDEFRMMYLNPMLSQWSLKKEMKPA----------IPASAPAPDT 263

  Fly   158 VDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGL 222
            .|||..|||:.||:||.||||||||.||.:|||.|:|:|.|:|||||.||||...  :..|.|||
Zfish   264 WDWRDHGAVSPVKNQGMCGSCWAFSVTGNIEGQWFKKTGQLLSLSEQELVDCDKL--DQACGGGL 326

  Fly   223 MDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVS 287
            ..||:..|::.||::||..|.|.....||.|:.|.|.|......::|: |||::|..:|..||||
Zfish   327 PSNAYEAIENLGGLETETDYSYTGHKQSCDFSTGKVAAYINSSVELPK-DEKEIAAFLAENGPVS 390

  Fly   288 VAIDASHESFQFYSEGVYNEPQ--CDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFI 350
            .|::|.  :.|||.:||.:..:  |:...:||.||:|||| ..:|..:|.:|||||..:|::|:.
Zfish   391 AALNAF--AMQFYRKGVSHPLKIFCNPWMIDHAVLLVGFG-QRNGVPFWAIKNSWGEDYGEQGYY 452

  Fly   351 KMLRNKENQCGIASASSYPLV 371
            .:.|. ...|||....|..:|
Zfish   453 YLYRG-SGLCGIHKMCSSAIV 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cp1	NP_523735.2	Inhibitor_I29	59..118	CDD:214853	15/58 (26%)
Cp1	NP_523735.2	Peptidase_C1	154..370	CDD:278538	96/217 (44%)
ctsf	NP_001071036.1	CY	34..144	CDD:214484
		PTZ00203	143..472	CDD:185513	123/344 (36%)
		Inhibitor_I29	175..231	CDD:214853	15/58 (26%)
		Peptidase_C1	262..471	CDD:278538	95/215 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53545
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100116
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.720