DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cp1 and ctsk

DIOPT Version :9

Sequence 1:	NP_523735.2	Gene:	Cp1 / 36546	FlyBaseID:	FBgn0013770	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	NP_001017778.1	Gene:	ctsk / 550475	ZFINID:	ZDB-GENE-001205-4	Length:	333	Species:	Danio rerio

Alignment Length:	336	Identity:	149/336 - (44%)
Similarity:	210/336 - (62%)	Gaps:	12/336 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 PLLALLAVAQAVSFADVVMEE-WHTFKLEHRKNYQDETEERFRLKIFNENKHKIAKHNQRFAEGK 101
            |||.||....|.|..::.::| |.::|:.|::.|....||..|..|:.:|...|..||:.:..|.
Zfish     8 PLLVLLWCGLAHSLDNLSLDEAWESWKITHKREYNGLNEESIRRTIWEKNMLFIEAHNKEYELGI 72

  Fly   102 VSFKLAVNKYADLLHHEFRQLMNGFNYTLHKQLRAADESFKGVTFISPAHV-TLPKSVDWRTKGA 165
            .::.|.:|.:.|:...|..:.:.|....:::.        ...||:....| .||||:|:|..|.
Zfish    73 HTYDLGMNHFGDMTLEEVAEKVMGLQMPMYRD--------PANTFVPDDRVGKLPKSIDYRKLGY 129

  Fly   166 VTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYI 230
            ||:||:||.|||||||||.||||||..:..|.||.||.||||||.|:  |:||.||.|.|||||:
Zfish   130 VTSVKNQGSCGSCWAFSSVGALEGQLMKTKGQLVDLSPQNLVDCVTE--NDGCGGGYMTNAFRYV 192

  Fly   231 KDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHE 295
            .:|.|||:|:||||...|..|.:|...|.|:.||:.:||||:|:.:..|||.||||||.|||...
Zfish   193 SNNQGIDSEESYPYVGTDQQCAYNTSGVAASCRGYKEIPQGNERALTAAVANVGPVSVGIDAMQS 257

  Fly   296 SFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQC 360
            :|.:|..|||.:|.|:.::::|.||.||:|....|:.||:||||||..||.||::.|.||:.|.|
Zfish   258 TFLYYKSGVYYDPNCNKEDVNHAVLAVGYGATPRGKKYWIVKNSWGEEWGKKGYVLMARNRNNAC 322

  Fly   361 GIASASSYPLV 371
            |||:.:|:|::
Zfish   323 GIANLASFPVM 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cp1	NP_523735.2	Inhibitor_I29	59..118	CDD:214853	16/58 (28%)
Cp1	NP_523735.2	Peptidase_C1	154..370	CDD:278538	119/215 (55%)
ctsk	NP_001017778.1	Inhibitor_I29	30..89	CDD:214853	16/58 (28%)
ctsk	NP_001017778.1	Peptidase_C1	118..332	CDD:278538	119/215 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53545
OrthoDB	1	1.010	-	-		D1275401at2759
OrthoFinder	1	1.000	-	-		FOG0000114
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100116
Panther	1	1.100	-	-	O	PTHR12411
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X64
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.830