DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cp1 and ctsll

DIOPT Version :9

Sequence 1:	NP_523735.2	Gene:	Cp1 / 36546	FlyBaseID:	FBgn0013770	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	XP_005165198.1	Gene:	ctsll / 449826	ZFINID:	ZDB-GENE-041010-76	Length:	337	Species:	Danio rerio

Alignment Length:	339	Identity:	177/339 - (52%)
Similarity:	228/339 - (67%)	Gaps:	12/339 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 LPLLALLAVAQAVSFADVVMEEWHTFKLEHRKNYQDETEERFRLKIFNENKHKIAKHNQRFAEGK 101
            |..|.:.||..|.:....:.:.||.:|..|.|:|. |.||.:|..::.:|..||..||...:.||
Zfish     7 LVTLCISAVFAAPTLDQKLDDHWHLWKRWHEKSYH-EKEEGWRRMVWEKNLKKIELHNLEHSVGK 70

  Fly   102 VSFKLAVNKYADLLHHEFRQLMNGFNYTLHKQLRAADESFKGVTFISPAHVTLPKSVDWRTKGAV 166
            .:|:|.:|::.|:.:.||||.|||:|       |..:...||..||.|:..|.|:.:|||.||.|
Zfish    71 HTFRLGMNQFGDMTNEEFRQAMNGYN-------RDPNRKSKGSLFIEPSFFTAPQQIDWRQKGYV 128

  Fly   167 TAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIK 231
            |.:|||..||||||||||||||||.|||:|.|||||||||:|||...|||||:|||||.||:|::
Zfish   129 TPIKDQKRCGSCWAFSSTGALEGQVFRKTGKLVSLSEQNLMDCSRPQGNNGCDGGLMDQAFQYVQ 193

  Fly   232 DNGGIDTEKSYPYEAIDDS-CHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHE 295
            ||.|:|:|:||||.|.||. ||::.....|...||.|||.|.|..:.:|||.||||:|||||.||
Zfish   194 DNNGLDSEESYPYLATDDQPCHYDPRYSAANVTGFVDIPSGKEHALMKAVAAVGPVAVAIDAGHE 258

  Fly   296 SFQFYSEGVYNEPQCDAQNLDHGVLVVGF---GTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKE 357
            |||||..|:|.|..|..:.|||||||||:   |.|.:|..||:|||||...|||||:|.|.::.:
Zfish   259 SFQFYQSGIYYEKACSTEELDHGVLVVGYGYEGVDVAGRRYWIVKNSWTDRWGDKGYIYMAKDLK 323

  Fly   358 NQCGIASASSYPLV 371
            |.||||:::||||:
Zfish   324 NHCGIATSASYPLM 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cp1	NP_523735.2	Inhibitor_I29	59..118	CDD:214853	21/58 (36%)
Cp1	NP_523735.2	Peptidase_C1	154..370	CDD:278538	134/219 (61%)
ctsll	XP_005165198.1	Inhibitor_I29	29..87	CDD:214853	21/58 (36%)
ctsll	XP_005165198.1	Peptidase_C1	116..336	CDD:278538	134/219 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	367	1.000	Inparanoid score	I2109
OMA	1	1.010	-	-		QHG53545
OrthoDB	1	1.010	-	-		D1275401at2759
OrthoFinder	1	1.000	-	-		FOG0000114
OrthoInspector	1	1.000	-	-		otm25207
orthoMCL	1	0.900	-	-		OOG6_100116
Panther	1	1.100	-	-	O	PTHR12411
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X64
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.880