DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cp1 and ctslb

DIOPT Version :9

Sequence 1:	NP_523735.2	Gene:	Cp1 / 36546	FlyBaseID:	FBgn0013770	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	NP_571273.2	Gene:	ctslb / 30443	ZFINID:	ZDB-GENE-980526-285	Length:	352	Species:	Danio rerio

Alignment Length:	340	Identity:	169/340 - (49%)
Similarity:	228/340 - (67%)	Gaps:	12/340 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 LLPLLALLAVAQAVSFADVVMEEWHTFKLEHRKNYQDETEERFRLKIFNENKHKIAKHNQRFAEG 100
            ||..|.:.||..|.|....:.:.|:::|.:|.|:|.::.|...|: |:.||..||.:||..::.|
Zfish    21 LLVTLYISAVFAAPSIDIQLDDHWNSWKSQHGKSYHEDVEVGRRM-IWEENLRKIEQHNFEYSYG 84

  Fly   101 KVSFKLAVNKYADLLHHEFRQLMNGFNYTLHKQLRAADESFKGVTFISPAHVTLPKSVDWRTKGA 165
            ..:||:.:|::.|:.:.||||.|||:.:.       .:::.:|..|:.|:....|:.||||.:|.
Zfish    85 NHTFKMGMNQFGDMTNEEFRQAMNGYTHD-------PNQTSQGPLFMEPSFFAAPQQVDWRQRGY 142

  Fly   166 VTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYI 230
            ||.||||..|||||:||||||||||.|||:|.|:|:|||||||||...||.||||||||.||:|:
Zfish   143 VTPVKDQKQCGSCWSFSSTGALEGQLFRKTGKLISMSEQNLVDCSRPQGNQGCNGGLMDQAFQYV 207

  Fly   231 KDNGGIDTEKSYPYEAIDD-SCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASH 294
            |:|.|:|:|:||||.|.|| .|.::.....|...||.|||.|:|..:..|||.||||||||||||
Zfish   208 KENKGLDSEQSYPYLARDDLPCRYDPRFNVAKITGFVDIPSGNELALMNAVAAVGPVSVAIDASH 272

  Fly   295 ESFQFYSEGVYNEPQCDAQNLDHGVLVVGF---GTDESGEDYWLVKNSWGTTWGDKGFIKMLRNK 356
            :|.|||..|:|.|..|.:..|||.|||||:   |.|.:|..||:|||||...|||||:|.|.::|
Zfish   273 QSLQFYQSGIYYERACSSSRLDHAVLVVGYGYQGADVAGNRYWIVKNSWSDKWGDKGYIYMAKDK 337

  Fly   357 ENQCGIASASSYPLV 371
            .|.||:|:.:||||:
Zfish   338 NNHCGVATKASYPLM 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cp1	NP_523735.2	Inhibitor_I29	59..118	CDD:214853	19/58 (33%)
Cp1	NP_523735.2	Peptidase_C1	154..370	CDD:278538	131/219 (60%)
ctslb	NP_571273.2	Inhibitor_I29	44..102	CDD:214853	19/58 (33%)
ctslb	NP_571273.2	Peptidase_C1	131..351	CDD:306594	131/219 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	367	1.000	Inparanoid score	I2109
OMA	1	1.010	-	-		QHG53545
OrthoDB	1	1.010	-	-		D1275401at2759
OrthoFinder	1	1.000	-	-		FOG0000114
OrthoInspector	1	1.000	-	-		otm25207
orthoMCL	1	0.900	-	-		OOG6_100116
Panther	1	1.100	-	-	O	PTHR12411
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X64
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.880