Protein Alignment CtsL1 and TINAG

DIOPT Version :10

• Sequence 1: NP_523735.2
• Gene: CtsL1 / 36546
• FlyBaseID: FBgn0013770
• Length: 371
• Species: Drosophila melanogaster
• Sequence 2: NP_055279.3
• Gene: TINAG / 27283
• HGNCID: 14599
• Length: 476
• Species: Homo sapiens
• Alignment Length: 284
• Identity: 77/284 - (27%)
• Similarity: 120/284 - (42%)
• Gaps: 66/284 - (23%)

  Fly   122 LMNGFNYTL-----HKQLRAADESFKGVTFISPAHVTLPK----SVDWR--TKGAVTAVKDQGHC 175
            |.:||.:.|     ...|.:.:|    :|...||...||:    |..|.  |.|.:    ||.:|
Human   184 LEDGFKFRLGTLPPSPMLLSMNE----MTASLPATTDLPEFFVASYKWPGWTHGPL----DQKNC 240

  Fly   176 GSCWAFSSTG------ALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNG 234
            .:.||||:..      |::.    |.....:||.|||:.|..| ..:|||.|.:|.|:.|::..
Human   241 AASWAFSTASVAADRIAIQS----KGRYTANLSPQNLISCCAK-NRHGCNSGSIDRAWWYLRKR- 299

  Fly   235 GIDTEKSYP----YEAIDDSC------------HFNK---GTVGATDRGFTDIP----QGDEKKM 276
            |:.:...||    ..|.::.|            |..|   ..|..::|.:...|    ..:|.::
Human   300 GLVSHACYPLFKDQNATNNGCAMASRSDGRGKRHATKPCPNNVEKSNRIYQCSPPYRVSSNETEI 364

  Fly   277 AEAVATVGPVSVAIDASHESFQFYSEGVY------NEPQCDAQNLD-HGVLVVGFGT----DESG 330
            .:.:...|||. ||....|.|..|..|:|      |:.....:.|. |.|.:.|:||    ....
Human   365 MKEIMQNGPVQ-AIMQVREDFFHYKTGIYRHVTSTNKESEKYRKLQTHAVKLTGWGTLRGAQGQK 428

  Fly   331 EDYWLVKNSWGTTWGDKGFIKMLR 354
            |.:|:..||||.:||:.|:.::||
Human   429 EKFWIAANSWGKSWGENGYFRILR 452

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CtsL1	NP_523735.2	Inhibitor_I29	59..118	CDD:214853
		Peptidase_C1	154..370	CDD:425470	68/247 (28%)
TINAG	NP_055279.3	Somatomedin_B	61..106	CDD:470596
		VWC	120..>154	CDD:450195
		Peptidase_C1A_CathepsinB	218..466	CDD:239111	67/246 (27%)