DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cp1 and Ctsz

DIOPT Version :9

Sequence 1:	NP_523735.2	Gene:	Cp1 / 36546	FlyBaseID:	FBgn0013770	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	NP_899159.1	Gene:	Ctsz / 252929	RGDID:	708479	Length:	306	Species:	Rattus norvegicus

Alignment Length:	249	Identity:	88/249 - (35%)
Similarity:	127/249 - (51%)	Gaps:	37/249 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 FISPAHVTLPKSVDWRTKGAV---TAVKDQ---GHCGSCWAFSSTGALEGQ-HFRKSGVLVS--L 201
            ::|||  .|||:.|||....|   :..::|   .:||||||..||.||..: :.::.|...|  |
  Rat    58 YLSPA--DLPKNWDWRNVNGVNYASVTRNQHIPQYCGSCWAHGSTSALADRINIKRKGAWPSTLL 120

  Fly   202 SEQNLVDCSTKYGNNG-CNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSC-HFNK-GTVGA--- 260
            |.||::||    ||.| |.||.....:.|...: ||..|....|:|.|..| .||: ||...
  Rat   121 SVQNVIDC----GNAGSCEGGNDLPVWEYAHKH-GIPDETCNNYQAKDQECDKFNQCGTCTEFKE 180

  Fly   261 --TDRGFTDIPQGD-------EKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLD 316
              |.:.:|....||       ||.|||..|. ||:|..|.|: |....|:.|:|.|.|..| .::
  Rat   181 CHTIQNYTLWRVGDYGSLSGREKMMAEIYAN-GPISCGIMAT-ERMSNYTGGIYTEYQNQA-IIN 242

  Fly   317 HGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPL 370
            |.:.|.|:|....|.:||:|:||||..||::|:::::.:....   .:.|||.|
  Rat   243 HIISVAGWGVSNDGIEYWIVRNSWGEPWGERGWMRIVTSTYKG---GTGSSYNL 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cp1	NP_523735.2	Inhibitor_I29	59..118	CDD:214853
Cp1	NP_523735.2	Peptidase_C1	154..370	CDD:278538	84/239 (35%)
Ctsz	NP_899159.1	Peptidase_C1A_CathepsinX	64..305	CDD:239149	85/241 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1275401at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820