DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cp1 and CTSZ

DIOPT Version :9

Sequence 1:	NP_523735.2	Gene:	Cp1 / 36546	FlyBaseID:	FBgn0013770	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	NP_001327.2	Gene:	CTSZ / 1522	HGNCID:	2547	Length:	303	Species:	Homo sapiens

Alignment Length:	236	Identity:	86/236 - (36%)
Similarity:	124/236 - (52%)	Gaps:	43/236 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 FISPAHVTLPKSVDWRTKGAV---TAVKDQ---GHCGSCWAFSSTGALEGQ-HFRKSGVLVS--L 201
            ::|||  .||||.|||....|   :..::|   .:||||||.:||.|:..: :.::.|...|  |
Human    56 YLSPA--DLPKSWDWRNVDGVNYASITRNQHIPQYCGSCWAHASTSAMADRINIKRKGAWPSTLL 118

  Fly   202 SEQNLVDCSTKYGNNG-CNGG----LMDNAFRYIKDNGGIDTEKSYPYEAIDDSC-HFNK-GTVG 259
            |.||::||    ||.| |.||    :.|.|.::     ||..|....|:|.|..| .||: ||..
Human   119 SVQNVIDC----GNAGSCEGGNDLSVWDYAHQH-----GIPDETCNNYQAKDQECDKFNQCGTCN 174

  Fly   260 A-----TDRGFTDIPQGD-------EKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDA 312
            .     ..|.:|....||       ||.|||..|. ||:|..|.|: |....|:.|:|.|.| |.
Human   175 EFKECHAIRNYTLWRVGDYGSLSGREKMMAEIYAN-GPISCGIMAT-ERLANYTGGIYAEYQ-DT 236

  Fly   313 QNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKML 353
            ..::|.|.|.|:|..: |.:||:|:||||..||::|:::::
Human   237 TYINHVVSVAGWGISD-GTEYWIVRNSWGEPWGERGWLRIV 276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cp1	NP_523735.2	Inhibitor_I29	59..118	CDD:214853
Cp1	NP_523735.2	Peptidase_C1	154..370	CDD:278538	83/228 (36%)
CTSZ	NP_001327.2	Peptidase_C1A_CathepsinX	62..302	CDD:239149	83/228 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1275401at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820