Protein Alignment CtsL1 and CTSS

DIOPT Version :10

• Sequence 1: NP_523735.2
• Gene: CtsL1 / 36546
• FlyBaseID: FBgn0013770
• Length: 371
• Species: Drosophila melanogaster
• Sequence 2: NP_004070.3
• Gene: CTSS / 1520
• HGNCID: 2545
• Length: 331
• Species: Homo sapiens
• Alignment Length: 341
• Identity: 164/341 - (48%)
• Similarity: 213/341 - (62%)
• Gaps: 14/341 - (4%)

  Fly    31 MRTAVLLPLLALLAVAQAVSFADVVME-EWHTFKLEHRKNYQDETEERFRLKIFNENKHKIAKHN 94
            |:..|.:.|:...||||.  ..|..:: .||.:|..:.|.|:::.||..|..|:.:|...:..||
Human     1 MKRLVCVLLVCSSAVAQL--HKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHN 63

  Fly    95 QRFAEGKVSFKLAVNKYADLLHHEFRQLMNGFNYTLHKQLRAADESFKGVTFISPAHVTLPKSVD 159
            ...:.|..|:.|.:|...|:...|...||:        .||...:..:.:|:.|..:..||.|||
Human    64 LEHSMGMHSYDLGMNHLGDMTSEEVMSLMS--------SLRVPSQWQRNITYKSNPNRILPDSVD 120

  Fly   160 WRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCST-KYGNNGCNGGLM 223
            ||.||.||.||.||.||:|||||:.||||.|...|:|.|||||.|||||||| ||||.|||||.|
Human   121 WREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFM 185

  Fly   224 DNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSV 288
            ..||:||.||.|||::.||||:|:|..|.::.....||...:|::|.|.|..:.||||..|||||
Human   186 TTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSV 250

  Fly   289 AIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKML 353
            .:||.|.||..|..|||.||.| .||::|||||||:| |.:|::|||||||||..:|::|:|:|.
Human   251 GVDARHPSFFLYRSGVYYEPSC-TQNVNHGVLVVGYG-DLNGKEYWLVKNSWGHNFGEEGYIRMA 313

  Fly   354 RNKENQCGIASASSYP 369
            |||.|.|||||..|||
Human   314 RNKGNHCGIASFPSYP 329

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CtsL1	NP_523735.2	Inhibitor_I29	59..118	CDD:214853	17/58 (29%)
		Peptidase_C1	154..370	CDD:425470	132/217 (61%)
CTSS	NP_004070.3	Inhibitor_I29	28..87	CDD:214853	17/58 (29%)
		Peptidase_C1	115..329	CDD:425470	130/215 (60%)