Protein Alignment Cp1 and CTSL

DIOPT Version :9

• Sequence 1: NP_523735.2
• Gene: Cp1 / 36546
• FlyBaseID: FBgn0013770
• Length: 371
• Species: Drosophila melanogaster
• Sequence 2: NP_001244900.1
• Gene: CTSL / 1514
• HGNCID: 2537
• Length: 333
• Species: Homo sapiens
• Alignment Length: 344
• Identity: 179/344 - (52%)
• Similarity: 232/344 - (67%)
• Gaps: 14/344 - (4%)

  Fly    31 MRTAVLLPLLALLAVAQAVSFADVVMEEWHTFKLEHRKNYQDETEERFRLKIFNENKHKIAKHNQ 95
            |...::|....|...:..::|...:..:|..:|..|.:.| ...||.:|..::.:|...|..|||
Human     1 MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLY-GMNEEGWRRAVWEKNMKMIELHNQ 64

  Fly    96 RFAEGKVSFKLAVNKYADLLHHEFRQLMNGFNYTLHKQLRAADESFKGVTFISPAHVTLPKSVDW 160
            .:.|||.||.:|:|.:.|:...||||:||||.   :::.|      ||..|..|.....|:||||
Human    65 EYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQ---NRKPR------KGKVFQEPLFYEAPRSVDW 120

  Fly   161 RTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDN 225
            |.||.||.||:||.||||||||:|||||||.|||:|.|:|||||||||||...||.||||||||.
Human   121 REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDY 185

  Fly   226 AFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAI 290
            ||:|::||||:|:|:||||||.::||.:|.....|.|.||.|||: .||.:.:|||||||:||||
Human   186 AFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPK-QEKALMKAVATVGPISVAI 249

  Fly   291 DASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFG---TDESGEDYWLVKNSWGTTWGDKGFIKM 352
            ||.||||.||.||:|.||.|.::::||||||||:|   |:.....|||||||||..||..|::||
Human   250 DAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKM 314

  Fly   353 LRNKENQCGIASASSYPLV 371
            .:::.|.||||||:|||.|
Human   315 AKDRRNHCGIASAASYPTV 333

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cp1	NP_523735.2	Inhibitor_I29	59..118	CDD:214853	20/58 (34%)
		Peptidase_C1	154..370	CDD:278538	140/218 (64%)
CTSL	NP_001244900.1	Inhibitor_I29	29..87	CDD:214853	20/58 (34%)
		Peptidase_C1	114..332	CDD:395062	140/218 (64%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	305	1.000	Domainoid score	I1367
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	360	1.000	Inparanoid score	I2210
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53545
OrthoDB	1	1.010	-	-		D1275401at2759
OrthoFinder	1	1.000	-	-		FOG0000114
OrthoInspector	1	1.000	-	-		otm40851
orthoMCL	1	0.900	-	-		OOG6_100116
Panther	1	1.100	-	-	LDO	PTHR12411
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3411
SonicParanoid	1	1.000	-	-		X64
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.910