DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cp1 and CTSB

DIOPT Version :9

Sequence 1:	NP_523735.2	Gene:	Cp1 / 36546	FlyBaseID:	FBgn0013770	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	NP_001371643.1	Gene:	CTSB / 1508	HGNCID:	2527	Length:	339	Species:	Homo sapiens

Alignment Length:	251	Identity:	74/251 - (29%)
Similarity:	105/251 - (41%)	Gaps:	47/251 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 LPKSVD----WRTKGAVTAVKDQGHCGSCWAFSSTGALEGQ---HFRKSGVLVSLSEQNLVDCST 211
            ||.|.|    |.....:..::|||.|||||||.:..|:..:   | ..:.|.|.:|.::|:.|..
Human    80 LPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIH-TNAHVSVEVSAEDLLTCCG 143

  Fly   212 KYGNNGCNGGLMDNAFRYIKDNGGID--TEKSY----PYEAIDDSCHFNKGTVGATDRGFTDIPQ 270
            ....:|||||....|:.:....|.:.  ..:|:    ||.......|.|......|..|  |.|:
Human   144 SMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEG--DTPK 206

  Fly   271 ---------------------------GDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEP 308
                                       ..||.:...:...|||..|... :..|..|..|||...
Human   207 CSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSV-YSDFLLYKSGVYQHV 270

  Fly   309 QCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIAS 364
            ..:... .|.:.::|:|. |:|..||||.|||.|.|||.||.|:||.::: |||.|
Human   271 TGEMMG-GHAIRILGWGV-ENGTPYWLVANSWNTDWGDNGFFKILRGQDH-CGIES 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cp1	NP_523735.2	Inhibitor_I29	59..118	CDD:214853
Cp1	NP_523735.2	Peptidase_C1	154..370	CDD:278538	74/251 (29%)
CTSB	NP_001371643.1	Propeptide_C1	26..65	CDD:400445
CTSB	NP_001371643.1	Peptidase_C1A_CathepsinB	81..328	CDD:239111	73/250 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53545
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820