DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cp1 and Ctsl

DIOPT Version :9

Sequence 1:	NP_523735.2	Gene:	Cp1 / 36546	FlyBaseID:	FBgn0013770	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	NP_034114.1	Gene:	Ctsl / 13039	MGIID:	88564	Length:	334	Species:	Mus musculus

Alignment Length:	342	Identity:	180/342 - (52%)
Similarity:	236/342 - (69%)	Gaps:	17/342 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 LLPLLALLAVAQAVS---FADVVMEEWHTFKLEHRKNYQDETEERFRLKIFNENKHKIAKHNQRF 97
            ||.|||:|.:..|::   |......|||.:|..||:.| ...||.:|..|:.:|...|..||..:
Mouse     3 LLLLLAVLCLGTALATPKFDQTFSAEWHQWKSTHRRLY-GTNEEEWRRAIWEKNMRMIQLHNGEY 66

  Fly    98 AEGKVSFKLAVNKYADLLHHEFRQLMNGFNYTLHKQLRAADESFKGVTFISPAHVTLPKSVDWRT 162
            :.|:..|.:.:|.:.|:.:.||||::||:.:..||         ||..|..|..:.:|||||||.
Mouse    67 SNGQHGFSMEMNAFGDMTNEEFRQVVNGYRHQKHK---------KGRLFQEPLMLKIPKSVDWRE 122

  Fly   163 KGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAF 227
            ||.||.||:||.||||||||::|.||||.|.|:|.|:|||||||||||...||.||||||||.||
Mouse   123 KGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHAQGNQGCNGGLMDFAF 187

  Fly   228 RYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDA 292
            :|||:|||:|:|:||||||.|.||.:......|.|.||.|||| .||.:.:|||||||:|||:||
Mouse   188 QYIKENGGLDSEESYPYEAKDGSCKYRAEFAVANDTGFVDIPQ-QEKALMKAVATVGPISVAMDA 251

  Fly   293 SHESFQFYSEGVYNEPQCDAQNLDHGVLVVGF---GTDESGEDYWLVKNSWGTTWGDKGFIKMLR 354
            ||.|.||||.|:|.||.|.::|||||||:||:   |||.:...|||||||||:.||.:|:||:.:
Mouse   252 SHPSLQFYSSGIYYEPNCSSKNLDHGVLLVGYGYEGTDSNKNKYWLVKNSWGSEWGMEGYIKIAK 316

  Fly   355 NKENQCGIASASSYPLV 371
            :::|.||:|:|:|||:|
Mouse   317 DRDNHCGLATAASYPVV 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cp1	NP_523735.2	Inhibitor_I29	59..118	CDD:214853	18/58 (31%)
Cp1	NP_523735.2	Peptidase_C1	154..370	CDD:278538	139/218 (64%)
Ctsl	NP_034114.1	Inhibitor_I29	29..87	CDD:214853	18/58 (31%)
Ctsl	NP_034114.1	Peptidase_C1	114..331	CDD:365882	138/217 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	303	1.000	Domainoid score	I1389
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H76699
Inparanoid	1	1.050	366	1.000	Inparanoid score	I2141
Isobase	1	0.950	-	0	Normalized mean entropy	S2922
OMA	1	1.010	-	-		QHG53545
OrthoDB	1	1.010	-	-		D1275401at2759
OrthoFinder	1	1.000	-	-		FOG0000114
OrthoInspector	1	1.000	-	-		otm42924
orthoMCL	1	0.900	-	-		OOG6_100116
Panther	1	1.100	-	-	LDO	PTHR12411
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3411
SonicParanoid	1	1.000	-	-		X64
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.860