DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rpn13 and adrm1

DIOPT Version :9

Sequence 1:	NP_001137662.1	Gene:	Rpn13 / 36545	FlyBaseID:	FBgn0033886	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	XP_005162019.1	Gene:	adrm1 / 796450	ZFINID:	ZDB-GENE-040426-905	Length:	411	Species:	Danio rerio

Alignment Length:	444	Identity:	188/444 - (42%)
Similarity:	255/444 - (57%)	Gaps:	91/444 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 GSSSNSSN-LVEFRAGRMNMVGKMVHPDPRKGLVYMTQSDDGLMHFCWKDRTSGKVEDDLIVFPD 72
            ||.|:||. |||||||:|.:.|..|.||.|||.||:.|:||.|:||||||||||.||||||:|||
Zfish    13 GSRSSSSKYLVEFRAGKMTLKGSTVTPDKRKGTVYIQQTDDSLIHFCWKDRTSGNVEDDLIIFPD 77

  Fly    73 DFEYKRVDQCKTGRVYVLKFKSSTRRMFFWMQEPKTDKDDEQCRRINELLNNP--PSAHQRGGGG 135
            |.|:|||:||.||||||||||:.::|:||||||||||||||.||::||.||||  |.|...||||
Zfish    78 DCEFKRVNQCTTGRVYVLKFKAGSKRLFFWMQEPKTDKDDEYCRKVNEYLNNPPMPGALGSGGGG 142

  Fly   136 SN-------DGDLQYMLNNMSQQQLMQLFG--GVGQMG-----GLSSLLGQ----MNSRTPSSRN 182
            .:       :|.||.:|.|||..|||||.|  |:|.:|     ||:||||.    .:|.|.|||:
Zfish   143 GHELSALGGEGGLQSLLGNMSHNQLMQLIGPTGLGGLGALAGPGLASLLGSGGPATSSSTSSSRS 207

  Fly   183 TSSS---GGGGASALQTPENVSVPRTPSAPSKSGSSRSSSNVNSQVGEGAGSSVDADAPGKNSTT 244
            .|::   ..|.|:.|.:.:..:.|.||:|.|.                           |..:.|
Zfish   208 QSAAATPSSGSAARLSSTQAPTTPVTPAATSS---------------------------GSPTVT 245

  Fly   245 STTTASKSTGAYANP-----------FQAYLSNLS----PEHGAGRSLNIDLSTALPGADAINQI 294
            .||.|:::....|.|           .|:.|:.::    |..|:|    :||::.|. .|.:..|
Zfish   246 PTTPAAQTPSLPAGPASSTQPIQLSDLQSILATMNVPAMPTEGSG----VDLASVLT-PDVMAPI 305

  Fly   295 IADPEHVKTLIVHLPESEDVDDDRKQQIKDNITSPQFQQALAQFSSALQSAQLGPVIKQFELSNE 359
            :|:||..:.|:.:||..|.:... .::|::.:||||||||::.|||||.|.||||::.||.|.:|
Zfish   306 LANPEVQQRLLPYLPSGESLPQS-AEEIQNTLTSPQFQQAMSMFSSALASGQLGPLMNQFGLPSE 369

  Fly   360 AVAAAFSGNLEDFVRALEKSLPPGATMGGKPSASEKKASDPETPTSVARDENTD 413
            ||.||..|::|.|.:|:|                   .||.:|....::|:..|
Zfish   370 AVDAANKGDVEAFAKAME-------------------GSDSKTDDGDSKDKKDD 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpn13	NP_001137662.1	PH_Rpn13	18..122	CDD:270124	75/103 (73%)
Rpn13	NP_001137662.1	RPN13_C	267..376	CDD:293158	45/112 (40%)
adrm1	XP_005162019.1	PH_Rpn13	23..127	CDD:270124	75/103 (73%)
		GET2	222..>308	CDD:285853	23/117 (20%)
		RPN13_C	279..386	CDD:293158	45/112 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581970
Domainoid	1	1.000	133	1.000	Domainoid score	I4999
eggNOG	1	0.900	-	-		E1_KOG3037
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	297	1.000	Inparanoid score	I2721
OMA	1	1.010	-	-		QHG59102
OrthoDB	1	1.010	-	-		D1479349at2759
OrthoFinder	1	1.000	-	-		FOG0003818
OrthoInspector	1	1.000	-	-		oto38708
orthoMCL	1	0.900	-	-		OOG6_102724
Panther	1	1.100	-	-	LDO	PTHR12225
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1994
SonicParanoid	1	1.000	-	-		X2662
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.840