Protein Alignment AGO1 and AGO3

DIOPT Version :10

• Sequence 1: NP_725341.1
• Gene: AGO1 / 36544
• FlyBaseID: FBgn0262739
• Length: 984
• Species: Drosophila melanogaster
• Sequence 2: NP_174414.1
• Gene: AGO3 / 840017
• AraportID: AT1G31290
• Length: 1194
• Species: Arabidopsis thaliana
• Alignment Length: 1009
• Identity: 301/1009 - (29%)
• Similarity: 489/1009 - (48%)
• Gaps: 123/1009 - (12%)

  Fly    34 GIIGKVYESQWTPSPTRPQSPSQAQTSFDTLTSPPAPGSSV-------NPTAVTSPSAQNVAAGG 91
            |..|:..:.|........||.||.|.|....|.....|:..       :.|.:.|.|:.||
plant   249 GHFGRGTQLQQPQPQAVSQSSSQGQVSQSFATGGVGLGAWARKPQLFSDSTVLPSSSSSNV---- 309

  Fly    92 ATVAGAAATAAQVASALGATTGSVTPAIATA---TPATQPDMPVFTCPRRPNLGREGRPIVLRAN 153
              ||...|:.:||          :||..:::   .|..:||       :..|:..:| .|.|..|
plant   310 --VASHTASGSQV----------MTPKPSSSDKKEPVKRPD-------KGGNIKVKG-VINLSVN 354

  Fly   154 HFQVTM-PRGYVHHYDINIQPDKCPRKVNR---EIIETMVHAYSKIFGVLKPVFDGRNNLYTRDP 214
            ||:|:. ....:.|||::|:.:...:|::|   .:::..:...:..|......:||:.|:::...
plant   355 HFRVSFSTESVIRHYDVDIKGENSSKKISRFELAMVKEKLFKDNNDFPNAMTAYDGQKNIFSAVE 419

  Fly   215 LPIGNERL---ELEVTLPGEGKDRIFRVTIKWQAQVSLFNLEEALEGRTRQIPYDAILALDVVMR 276
            ||.|:.::   |.|..:.|    |.:...||...::.|.:|:..::||:..||.|.:..:||||:
plant   420 LPTGSFKVDFSETEEIMRG----RSYTFIIKQVKELKLLDLQAYIDGRSTFIPRDVLQGMDVVMK 480

  Fly   277 HLPSMTYTPVGRSFFSS----PEGYYHPLGGGREVWFGFHQSVRPSQWKMMLNIDVSATAFYKAQ 337
            ..||.....||:.|||:    ..||  .:|..:    |||.:::|:...:.|.::.|..||.||.
plant   481 EHPSKRMITVGKRFFSTRLEIDFGY--GVGAAK----GFHHTLKPTVQGLSLCLNSSLLAFRKAI 539

  Fly   338 PVIDFMCEVLDIRDINEQRKPLTDSQRVKFTKEIKGLKIEITHCGQMRRKYRVCNVTRRPAQMQS 402
            .||:::......|:|.:.:....|.    ..:|:.|||:.:.| .:.::|:.:..:::...:...
plant   540 SVIEYLKLYFGWRNIRQFKNCRPDD----VVQELIGLKVTVDH-RKTKQKFIIMGLSKDDTKDIK 599

  Fly   403 FPL--QLENGQTVECTVAKYFLDKYRMKLRYPHLPCLQVGQEHKHTYLPLEVCNIVAGQRCIKKL 465
            |..  ...|....:.::.:||.:||...:.:..:|||.:|::.:..::|:|.||:|.||...|:.
plant   600 FDFIDHAGNQPPRKISIVEYFKEKYGRDIDHKDIPCLNLGKKGRENFVPMEFCNLVEGQIFPKEK 664

  Fly   466 TDMQTSTMIKATARSAPDRERE-INNLVKRADF-NNDSYVQEFGLTISNSMMEVRGRVLPPPKLQ 528
            ....::..:|..:...|.:..| ||.::|.:|. .....:..|||.:..:|..|.||||..|.|:
plant   665 LYRDSAAWLKELSLVTPQQRLENINKMIKSSDGPRGGDIIGNFGLRVDPNMTTVEGRVLEAPTLK 729

  Fly   529 YGGRVSTGLTGQQLFPPQNKVSLASPNQGVWDMRGKQFFTGVEIRIWAIACFAPQRTVREDALRN 593
                    ||.::..|...|: ::..||  |::..|....|..|:.||:..|....::::.....
plant   730 --------LTDRRGNPIHEKL-MSESNQ--WNLTTKGVTKGSIIKHWAVLDFTASESLKKKMPGY 783

  Fly   594 FTQQLQKISNDAGMPIIGQPCFCKYAT-----GPDQVEPMFRYL----KITFPGL--QLVVVVLP 647
            |..:|.:.....||. :..|..||.::     ..:.:|.:.|.:    .....|.  .||:..:.
plant   784 FVNKLIERCKGLGMQ-MEAPIVCKTSSMETLYDGNALEELLRSVIDEASHNHGGACPTLVLCAMT 847

  Fly   648 GKTPVYAEVKRVGDTVLGMATQC---VQAKNVNKTSPQTLSNLCLKINVKLGGINSILVPSIRPK 709
            ||...|..:|.:.:|.||:.|||   :.|......|.|.|:||.||||.|:||.|..||.:|
plant   848 GKHDGYKTLKWIAETKLGLVTQCFLTISAIKGETVSDQYLANLALKINAKVGGTNVELVDNI--- 909

  Fly   710 VFN-----EPVIFLGADVTHPPAGDNKKPSIAAVVGSMD-AHPSRYAATVRVQQHRQEIIQELSS 768
             |:     :.|:|:||||.||.|.||..|||.||||::: ...:||||.|:.|.||:|.||....
plant   910 -FSFFKKEDKVMFIGADVNHPAAHDNMSPSIVAVVGTLNWPEANRYAARVKAQSHRKEEIQGFGE 973

  Fly   769 MVRELLIMFYKSTGGYKPHRIILYRDGVSEGQFPHVLQHELTAIREACIKLEPEYRPGITFIVVQ 833
            ...| ||..:......:|::|:::|||||:|||..||..||..:::...|:  .|.|.||.||.|
plant   974 TCWE-LIEAHSQAPEKRPNKIVIFRDGVSDGQFDMVLNVELQNVKDVFAKV--GYNPQITVIVAQ 1035

  Fly   834 KRHHTRLFCAEKKEQSGKSGNIPAGTTVDVGITHPTEFDFYLCSHQGIQGTSRPSHYHVLWDDNH 898
            |||.||.|.|...:.....||:|:||.||..|.||.|:||||||..|..|||:|:||:||.|:..
plant  1036 KRHQTRFFPATTSKDGRAKGNVPSGTVVDTTIIHPFEYDFYLCSQHGAIGTSKPTHYYVLSDEIG 1100

  Fly   899 FDSDELQCLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYH----LVEKEHDSGEGSHQSGCS 959
            |:|:::|.|.:.||.|:.|||:.|::..|..||...|.|.|.:    |::|......|:..|..|
plant  1101 FNSNQIQKLIFDLCFTFTRCTKPVALVPPVSYADKAASRGRVYYEASLMKKNSKQSRGASSSSAS 1165

  Fly   960 ----------EDRTPGAMARAITVHADTKKVMYF 983
                      ||:      ....|||..:..|:|
plant  1166 VASSSSSVTMEDK------EIFKVHAGIENFMFF 1193

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO1	NP_725341.1	ArgoN	146..275	CDD:465134	34/135 (25%)
		ArgoL1	285..335	CDD:462567	16/53 (30%)
		PAZ_argonaute_like	336..456	CDD:239212	26/121 (21%)
		Piwi_ago-like	502..942	CDD:240015	169/463 (37%)
AGO3	NP_174414.1	ArgoN	409..479	CDD:465134	21/73 (29%)
		PAZ	542..665	CDD:460472	28/127 (22%)
		Piwi_ago-like	703..1144	CDD:240015	169/459 (37%)