DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGO1 and AGO10

DIOPT Version :9

Sequence 1:	NP_001246314.1	Gene:	AGO1 / 36544	FlyBaseID:	FBgn0262739	Length:	984	Species:	Drosophila melanogaster
Sequence 2:	NP_001190464.1	Gene:	AGO10 / 834403	AraportID:	AT5G43810	Length:	988	Species:	Arabidopsis thaliana

Alignment Length:	1017	Identity:	398/1017 - (39%)
Similarity:	553/1017 - (54%)	Gaps:	145/1017 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 TPSP---TRPQSPSQAQTSFDTLTSPPAPGSSVN-------------------------PTAVTS 81
            :|||   |.|.:.:|:|.|   ..|||:...|..                         |.:.|:
plant    38 SPSPVTVTTPATVTQSQAS---SPSPPSKNRSRRRNRGGRKSDQGDVCMRPSSRPRKPPPPSQTT 99

  Fly    82 PSAQNVAAGGATVAGAAATAAQVASALGATTGSVTPAIATATPATQPDMPVFTCPRRPNLGREGR 146
            .||.:||..|..|      |......:|....|      ...|             ||..|..|.
plant   100 SSAVSVATAGEIV------AVNHQMQMGVRKNS------NFAP-------------RPGFGTLGT 139

  Fly   147 PIVLRANHFQVTMPRGYVHHYDINIQPDKCPRKVNREIIETMVHAYSKI-FGVLKPVFDGRNNLY 210
            ..:::||||...:|...::.||:.|.|:...:.|||.||..:|..|.:. .|...|.:|||.:||
plant   140 KCIVKANHFLADLPTKDLNQYDVTITPEVSSKSVNRAIIAELVRLYKESDLGRRLPAYDGRKSLY 204

  Fly   211 TRDPLPIGNERLELEVT------LPGEGKDRIFRVTIKWQAQVSLFNLEEALEGRTRQIPYDAIL 269
            |...||...:...:::.      :.|..::|.::|.||:.|:.::.:|.|.|.|:....|.:|:.
plant   205 TAGELPFTWKEFSVKIVDEDDGIINGPKRERSYKVAIKFVARANMHHLGEFLAGKRADCPQEAVQ 269

  Fly   270 ALDVVMRHLPSMTYTPVGRSFFSSPEGYYHPLGGGREVWFGFHQSVRPSQWKMMLNIDVSATAFY 334
            .||:|:|.|....:.||||||||........||.|.|.|.||:||:||:|..:.||||:::.||.
plant   270 ILDIVLRELSVKRFCPVGRSFFSPDIKTPQRLGEGLESWCGFYQSIRPTQMGLSLNIDMASAAFI 334

  Fly   335 KAQPVIDFMCEVLDIRDINEQRKPLTDSQRVKFTKEIKGLKIEITHCGQMRRKYRVCNVTRRPAQ 399
            :..|||:|:.::|. :|:  ..|||:||.|||..|.::|:|:|:||...:||||||..:|.:|.:
plant   335 EPLPVIEFVAQLLG-KDV--LSKPLSDSDRVKIKKGLRGVKVEVTHRANVRRKYRVAGLTTQPTR 396

  Fly   400 MQSFPLQLENGQTVECT---VAKYFLDKYRMKLRYPHLPCLQVGQEHKHTYLPLEVCNIVAGQRC 461
            ...||:. ||     ||   |.:||.:.|...:::.||||||||.:.|.:|||:|.|.||.|||.
plant   397 ELMFPVD-EN-----CTMKSVIEYFQEMYGFTIQHTHLPCLQVGNQKKASYLPMEACKIVEGQRY 455

  Fly   462 IKKLTDMQTSTMIKATARSAPDREREINNLVKRADFNNDSYVQEFGLTISNSMMEVRGRVLPPPK 526
            .|:|.:.|.:.::|.|.:...|||.:|...|:...::.|.|.:|||:.||..:..|..|:||.|.
plant   456 TKRLNEKQITALLKVTCQRPRDRENDILRTVQHNAYDQDPYAKEFGMNISEKLASVEARILPAPW 520

  Fly   527 LQY--GGRVSTGLTGQQLFPPQNKVSLASPNQGVWDMRGKQFFTGVEIRIWAIACFAPQRTVRED 589
            |:|  .|:....|                |..|.|:|..|:...|:.:..||...|:  |:|:|:
plant   521 LKYHENGKEKDCL----------------PQVGQWNMMNKKMINGMTVSRWACVNFS--RSVQEN 567

  Fly   590 ALRNFTQQLQKISNDAGMPIIGQPCFCKYATGPDQVEPMFRYL------KITFPGLQLVVVVLPG 648
            ..|.|..:|.::...:||....:|....|:..|||||...:::      |.....|:|::.:||.
plant   568 VARGFCNELGQMCEVSGMEFNPEPVIPIYSARPDQVEKALKHVYHTSMNKTKGKELELLLAILPD 632

  Fly   649 KT-PVYAEVKRVGDTVLGMATQCVQAKNVNKTSPQTLSNLCLKINVKLGGINSILVPSIR---PK 709
            .. .:|.::||:.:|.||:.:||...|:|.|.|.|.|:|:.||||||:||.|::||.:|.   |.
plant   633 NNGSLYGDLKRICETELGLISQCCLTKHVFKISKQYLANVSLKINVKMGGRNTVLVDAISCRIPL 697

  Fly   710 VFNEPVIFLGADVTHPPAGDNKKPSIAAVVGSMD-AHPSRYAATVRVQQHRQEIIQEL------- 766
            |.:.|.|..|||||||..|:...|||||||.|.| ...::||..|..|.||||:||:|
plant   698 VSDIPTIIFGADVTHPENGEESSPSIAAVVASQDWPEVTKYAGLVCAQAHRQELIQDLYKTWQDP 762

  Fly   767 ------SSMVRELLIMFYKSTGGYKPHRIILYRDGVSEGQFPHVLQHELTAIREACIKLEPEYRP 825
                  ..|:|:|||.|.|:| |.||.|||.||||||||||..||.:||.|||:||..|||.|:|
plant   763 VRGTVSGGMIRDLLISFRKAT-GQKPLRIIFYRDGVSEGQFYQVLLYELDAIRKACASLEPNYQP 826

  Fly   826 GITFIVVQKRHHTRLFCAEKKEQSG--KSGNIPAGTTVDVGITHPTEFDFYLCSHQGIQGTSRPS 888
            .:||||||||||||||....::::.  :||||..||.||..|.||||||||||||.||||||||:
plant   827 PVTFIVVQKRHHTRLFANNHRDKNSTDRSGNILPGTVVDTKICHPTEFDFYLCSHAGIQGTSRPA 891

  Fly   889 HYHVLWDDNHFDSDELQCLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVEKEHDSGEGS 953
            |||||||:|:|.:|.:|.||..||:||.||||||||..|||||||.|||||::| |.|.....||
plant   892 HYHVLWDENNFTADGIQSLTNNLCYTYARCTRSVSIVPPAYYAHLAAFRARFYL-EPEIMQDNGS 955

  Fly   954 HQSGCSEDRTPGAMARAITVHAD------------TKKVMYF 983
                      ||......|...|            .|:||::
plant   956 ----------PGKKNTKTTTVGDVGVKPLPALKENVKRVMFY 987

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGO1	NP_001246314.1	ArgoN	146..275	CDD:406799	40/135 (30%)
		ArgoL1	285..335	CDD:400854	26/49 (53%)
		PAZ_argonaute_like	336..456	CDD:239212	52/122 (43%)
		Piwi_ago-like	502..942	CDD:240015	221/467 (47%)
AGO10	NP_001190464.1	PLN03202	131..988	CDD:215631	374/896 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	337	1.000	Domainoid score	I247
eggNOG	1	0.900	-	-		E1_KOG1041
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	688	1.000	Inparanoid score	I140
OMA	1	1.010	-	-		QHG58336
OrthoDB	1	1.010	-	-		D159407at2759
OrthoFinder	1	1.000	-	-		FOG0000468
OrthoInspector	1	1.000	-	-		otm2495
orthoMCL	1	0.900	-	-		OOG6_100361
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X379
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840