DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGO1 and AGO9

DIOPT Version :9

Sequence 1:	NP_001246314.1	Gene:	AGO1 / 36544	FlyBaseID:	FBgn0262739	Length:	984	Species:	Drosophila melanogaster
Sequence 2:	NP_197613.2	Gene:	AGO9 / 832241	AraportID:	AT5G21150	Length:	896	Species:	Arabidopsis thaliana

Alignment Length:	931	Identity:	298/931 - (32%)
Similarity:	451/931 - (48%)	Gaps:	122/931 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 ATATPATQPDMPVFTCP-RRP-NLGREGRPIVLRANHFQV--TMPRGYVHHYDINIQ-PDKCP-- 177
            |...|..:|.......| .|| ..|.:|:.|.|..|||.|  ..|.||..||.:.|. .|..|
plant    20 ANLVPEVEPVKKNILLPMARPRGSGSKGQKIPLLTNHFGVKFNKPSGYFFHYSVAINYEDGRPVE 84

  Fly   178 -RKVNREIIETMVHAYSKIFGVLKPVFDGRNNLYTRDPLPIGNERLELEVTL------------- 228
             :.:.|:|::.:...|....|.....:||...|:|...||  :.:|:..|.|
plant    85 AKGIGRKILDKVQETYQSDLGAKYFAYDGEKTLFTVGALP--SNKLDFSVVLEEIPSSRNHAGND 147

  Fly   229 -----------PGEGKDRIFRVTIKWQAQVSLFNLEEALEGRTRQIPYDAILALDVVMRHLPS-M 281
                       |.:.|.  |.|.|.:.|::.:..:..||:|:..:...||:..||:::|...: .
plant   148 TNDADRKRSRRPNQTKK--FMVEISYAAKIPMQAIASALQGKETENLQDALRVLDIILRQSAARQ 210

  Fly   282 TYTPVGRSFFSSPEGYYHPLGGGREVWFGFHQSVRPSQWKMMLNIDVSATAFYKAQPVIDFMCEV 346
            ....|.:|||.:....:.|:|||.....|||.|.|.:|..:.||||.|.|...:..||:||:.
plant   211 GCLLVRQSFFHNDVKNFVPIGGGVSGCRGFHSSFRTTQGGLSLNIDTSTTMIVQPGPVVDFLL-- 273

  Fly   347 LDIRDINEQRKPLTDSQRVKFTKEIKGLKIEITHCGQMRRKYRVCNVTRRPAQMQSFPLQLENG- 410
                 .|:.:|........|..:.:|.|:::||   ...|:|::..::....:.|.|..:..|.
plant   274 -----ANQNKKDPYGMDWNKARRVLKNLRVQIT---LSNREYKISGLSEHSCKDQLFTWRKPNDK 330

  Fly   411 ---QTVECTVAKYFLDKYRMKLRYP-HLPCLQVGQEHKHTYLPLEVCNIVAGQRCIKKLTDMQTS 471
               :.||.||..|:.:: .:::||. ..||:.||:..:.||.|:|.||:|:.||..|.||:.|.:
plant   331 GEFEEVEITVLNYYKER-NIEVRYSGDFPCINVGKPKRPTYFPIEFCNLVSLQRYTKSLTNFQRA 394

  Fly   472 TMIKATARSAPDREREINNLVKRADFNNDSYVQEFGLTISNSMMEVRGRVLPPPKLQYGGRVSTG 536
            .:::.:.:..|:|...:...:|.:::|.|..:|:.|::|..:..:|.||:||.|.|:.|
plant   395 ALVEKSRQKPPERMASLTKGLKDSNYNADPVLQDSGVSIITNFTQVEGRILPTPMLKVG------ 453

  Fly   537 LTGQQLFPPQNKVSLASPNQGVWDMRGKQFFTGVEIRIWAIACFAPQ---RTVREDALR------ 592
             .|:.|          ||.:|.|:...|.......:..||:..|:.:   .|:..|.::
plant   454 -KGENL----------SPIKGKWNFMRKTLAEPTTVTRWAVVNFSARCDTNTLIRDLIKCGREKG 507

  Fly   593 -NFTQQLQKISNDAGMPIIGQPCFCKYATGPDQVEPMFRYL--KITFPGLQLVVVVLPGK-TPVY 653
             |.....:.:.|:       .|.| :.|....:||.||..:  |:..|.|.|:.::...| :.||
plant   508 INVEPPFKDVINE-------NPQF-RNAPATVRVENMFEQIKSKLPKPPLFLLCILAERKNSDVY 564

  Fly   654 AEVKRVGDTVLGMATQCVQAKNVNKTSPQTLSNLCLKINVKLGGINSILV----PSIRPKVFNEP 714
            ...|:.....||:.|||:....:|   .|.|:|:.||||.||||:||:|.    |:: |||...|
plant   565 GPWKKKNLVDLGIVTQCIAPTRLN---DQYLTNVLLKINAKLGGLNSLLAMERSPAM-PKVTQVP 625

  Fly   715 VIFLGADVTHPPAGDNKKPSIAAVVGSMDAHP--SRYAATVRVQQHRQEIIQEL--------SSM 769
            .|.:|.||:|...|.:..|||||||.|.. .|  |:|.|.||.|..:.|:|..|        ..|
plant   626 TIIVGMDVSHGSPGQSDIPSIAAVVSSRQ-WPLISKYKACVRTQSRKMEMIDNLFKPVNGKDEGM 689

  Fly   770 VRELLIMFYKSTGGYKPHRIILYRDGVSEGQFPHVLQHELTAIREACIKLEPEYRPGITFIVVQK 834
            .||||:.||.|:...||..||::||||||.||..||..||..:.:||..|:..:.|..|.||.||
plant   690 FRELLLDFYYSSENRKPEHIIIFRDGVSESQFNQVLNIELDQMMQACKFLDDTWHPKFTVIVAQK 754

  Fly   835 RHHTRLFCAEKKEQSGKSGNIPAGTTVDVGITHPTEFDFYLCSHQGIQGTSRPSHYHVLWDDNHF 899
            .|||:.|      ||....|:|.||.:|..|.||..||||||:|.|:.||:||:|||||:|:..|
plant   755 NHHTKFF------QSRGPDNVPPGTIIDSQICHPRNFDFYLCAHAGMIGTTRPTHYHVLYDEIGF 813

  Fly   900 DSDELQCLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVEKEHDSGEGSHQSGCSEDRTP 964
            .:|:||.|.:.|.:.|.|.|.::|:.||..||||.|  |:...|.|..:..|.|...|  ...||
plant   814 ATDDLQELVHSLSYVYQRSTTAISVVAPVCYAHLAA--AQMGTVMKYEELSETSSSHG--GITTP 874

  Fly   965 GA--MARAITVHADTKKVMYF 983
            ||  :.....:|.:....|:|
plant   875 GAVPVPPMPQLHNNVSTSMFF 895

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGO1	NP_001246314.1	ArgoN	146..275	CDD:406799	40/158 (25%)
		ArgoL1	285..335	CDD:400854	20/49 (41%)
		PAZ_argonaute_like	336..456	CDD:239212	33/124 (27%)
		Piwi_ago-like	502..942	CDD:240015	172/466 (37%)
AGO9	NP_197613.2	PLN03202	17..896	CDD:215631	298/931 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1041
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D159407at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920