DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGO1 and AGO6

DIOPT Version :9

Sequence 1:	NP_001246314.1	Gene:	AGO1 / 36544	FlyBaseID:	FBgn0262739	Length:	984	Species:	Drosophila melanogaster
Sequence 2:	NP_180853.2	Gene:	AGO6 / 817856	AraportID:	AT2G32940	Length:	878	Species:	Arabidopsis thaliana

Alignment Length:	945	Identity:	287/945 - (30%)
Similarity:	444/945 - (46%)	Gaps:	143/945 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 TGSVTPAIATATPATQPDMPVFTCPRRPNLGREGRPIVLRANHFQVTM--PRGYVHHYDINIQPD 174
            |.|..|....:....||....:....|..:|..|.||.|..|||.|::  |....:.|.::|..:
plant     3 TSSSLPLSPISIEPEQPSHRDYDITTRRGVGTTGNPIELCTNHFNVSVRQPDVVFYQYTVSITTE 67

  Fly   175 KCP----RKVNREIIETMVHAYSKIFGVLKPVFDGRNNLYTRDPLPIGNERLELEVTLPGEGK-- 233
            ...    ..::|::::.:...||......:..:||...|||..|||    :.|.:..:..||.
plant    68 NGDAVDGTGISRKLMDQLFKTYSSDLDGKRLAYDGEKTLYTVGPLP----QNEFDFLVIVEGSFS 128

  Fly   234 ------------------------DRIFRVTIKWQAQVSLFNLEEALEGRTR------QIPYDAI 268
                                    .|.::|.|.:.|::.|    :.:.|..|      :...||:
plant   129 KRDCGVSDGGSSSGTCKRSKRSFLPRSYKVQIHYAAEIPL----KTVLGTQRGAYTPDKSAQDAL 189

  Fly   269 LALDVVMRHLPSMTYTPVGRSFFSSPEGYYHPLGGGREVWFGFHQSVRPSQWKMMLNIDVSATAF 333
            ..||:|:|...:.....:.|..|...:|:...:|||.....|.|.|.||:...:.||||||.|..
plant   190 RVLDIVLRQQAAERGCLLVRQAFFHSDGHPMKVGGGVIGIRGLHSSFRPTHGGLSLNIDVSTTMI 254

  Fly   334 YKAQPVIDFMCEVLDIRDINEQRKPLTDSQRVKFTKEIKGLKIEITHCGQMRRKYRVCNVTRRPA 398
            .:..|||:|:       ..|:..:.......:|..|.:|.::::.||   ...::::..::.:|.
plant   255 LEPGPVIEFL-------KANQSVETPRQIDWIKAAKMLKHMRVKATH---RNMEFKIIGLSSKPC 309

  Fly   399 QMQSFPLQLENGQTV----ECTVAKYFLDKYRMKLRYPHLPCLQVGQEHKHTYLPLEVCNIVAGQ 459
            ..|.|.:::::|:..    |.||..||...|...:...:.|||.||:..:..|||||.||:|:.|
plant   310 NQQLFSMKIKDGEREVPIREITVYDYFKQTYTEPISSAYFPCLDVGKPDRPNYLPLEFCNLVSLQ 374

  Fly   460 RCIKKLTDMQTSTMIKATARSAPDREREINNLVKRADFNNDSYVQEFGLTISNSMMEVRGRVLPP 524
            |..|.|:..|...:::::.:...:|.:.:|:.:....::.|.::...|::|...|.:|.||||.|
plant   375 RYTKPLSGRQRVLLVESSRQKPLERIKTLNDAMHTYCYDKDPFLAGCGISIEKEMTQVEGRVLKP 439

  Fly   525 PKLQYGGRVSTGLTGQQLFPPQNKVSLASPNQGVWDMRGKQFFTGVEIRIWAIACFA-P------ 582
            |.|::|        ..:.|.|.|         |.|:...|.......|:.|||..|: |
plant   440 PMLKFG--------KNEDFQPCN---------GRWNFNNKMLLEPRAIKSWAIVNFSFPCDSSHI 487

  Fly   583 QRTVREDALRNFTQQLQKISNDAGMPIIGQPCFCKYATGPDQVEPMFRYLKITFPG-LQLVVVVL 646
            .|.:....:|      :.|..|....::.:....|.|...::||.|...:|:.||. ...::.:|
plant   488 SRELISCGMR------KGIEIDRPFALVEEDPQYKKAGPVERVEKMIATMKLKFPDPPHFILCIL 546

  Fly   647 PGK--TPVYAEVKRVGDTVLGMATQCVQAKNVNKTSPQTLSNLCLKINVKLGGINSIL------- 702
            |.:  :.:|...|::..|..|:.|||:..   .|.|.|.|:|:.||||.|||||||:|
plant   547 PERKTSDIYGPWKKICLTEEGIHTQCICP---IKISDQYLTNVLLKINSKLGGINSLLGIEYSYN 608

  Fly   703 VPSIRPKVFNEPVIFLGADVTHPPAGDNKKPSIAAVVGSMDAHP--SRYAATVRVQQHRQEIIQE 765
            :|.|. |:   |.:.||.||:|.|.|....||:|||||| ...|  |||.|.||.|..|.|:|..
plant   609 IPLIN-KI---PTLILGMDVSHGPPGRADVPSVAAVVGS-KCWPLISRYRAAVRTQSPRLEMIDS 668

  Fly   766 L-----------SSMVRELLIMFYKSTGGYKPHRIILYRDGVSEGQFPHVLQHELTAIREACIKL 819
            |           :.::.||.:.||:::...||.:||::||||||.||..||:.|:..|.:|..:|
plant   669 LFQPIENTEKGDNGIMNELFVEFYRTSRARKPKQIIIFRDGVSESQFEQVLKIEVDQIIKAYQRL 733

  Fly   820 EPEYRPGITFIVVQKRHHTRLFCAEKKEQSGKSGNIPAGTTVDVGITHPTEFDFYLCSHQGIQGT 884
            .....|..|.||.||.|||:||.|:..|      |:||||.||..|.|||.:|||:|:|.|..||
plant   734 GESDVPKFTVIVAQKNHHTKLFQAKGPE------NVPAGTVVDTKIVHPTNYDFYMCAHAGKIGT 792

  Fly   885 SRPSHYHVLWDDNHFDSDELQCLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFR-ARYHLVEKEHD 948
            |||:|||||.|:..|..|:||.|.:.|.:...|.|.:.||.||..||||.|.: |::...|
plant   793 SRPAHYHVLLDEIGFSPDDLQNLIHSLSYVNQRSTTATSIVAPVRYAHLAAAQVAQFTKFE---- 853

  Fly   949 SGEGSHQSGCSEDRTPGAMARAITVHADTKKVMYF 983
                    |.|||   |.:.....:|.:.:..|:|
plant   854 --------GISED---GKVPELPRLHENVEGNMFF 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGO1	NP_001246314.1	ArgoN	146..275	CDD:406799	35/166 (21%)
		ArgoL1	285..335	CDD:400854	18/49 (37%)
		PAZ_argonaute_like	336..456	CDD:239212	32/123 (26%)
		Piwi_ago-like	502..942	CDD:240015	174/470 (37%)
AGO6	NP_180853.2	PLN03202	15..878	CDD:215631	284/933 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1041
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910