Protein Alignment AGO1 and AGO4

DIOPT Version :10

• Sequence 1: NP_725341.1
• Gene: AGO1 / 36544
• FlyBaseID: FBgn0262739
• Length: 984
• Species: Drosophila melanogaster
• Sequence 2: NP_565633.1
• Gene: AGO4 / 817246
• AraportID: AT2G27040
• Length: 924
• Species: Arabidopsis thaliana
• Alignment Length: 963
• Identity: 308/963 - (31%)
• Similarity: 471/963 - (48%)
• Gaps: 129/963 - (13%)

  Fly   102 AQVASALGATTGSVTPAIATATPATQPDM--------------PVFTCPRRPNLGREGRPIVLRA 152
            |.:.||.||....||.|:....|...|::              ||.....|...|..|:.|.|..
plant     9 ADLESANGANGSGVTEALPPPPPVIPPNVEPVRVKTELAEKKGPVRVPMARKGFGTRGQKIPLLT 73

  Fly   153 NHFQVTMP--RGYVHHYDINI-QPDKCP---RKVNREIIETMVHAYSKIFGVLKPVFDGRNNLYT 211
            |||:|.:.  :|:..||.:.: ..|..|   :.|.|:|::.:...|.......:..:||...|:|
plant    74 NHFKVDVANLQGHFFHYSVALFYDDGRPVEQKGVGRKILDKVHQTYHSDLDGKEFAYDGEKTLFT 138

  Fly   212 RDPLPIGNERLELEVTL-------------------PGEG---------KDRIFRVTIKWQAQVS 248
            ...||  :.:::..|.|                   |.:|         :.:.|||.|.:.|::.
plant   139 YGALP--SNKMDFSVVLEEVSATRANGNGSPNGNESPSDGDRKRLRRPNRSKNFRVEISYAAKIP 201

  Fly   249 LFNLEEALEGRTRQIPYDAILALDVVMR-HLPSMTYTPVGRSFFSSPEGYYHPLGGGREVWFGFH 312
            |..|..|:.|:..:...:||..||:::| |........|.:|||.:......|:||......|||
plant   202 LQALANAMRGQESENSQEAIRVLDIILRQHAARQGCLLVRQSFFHNDPTNCEPVGGNILGCRGFH 266

  Fly   313 QSVRPSQWKMMLNIDVSATAFYKAQPVIDFMCEVLDIRDINEQRKPLT-DSQRVKFTKEIKGLKI 376
            .|.|.:|..|.||:||:.|...|..||:||:....:.||      |.: |..:.|.|  :|.|::
plant   267 SSFRTTQGGMSLNMDVTTTMIIKPGPVVDFLIANQNARD------PYSIDWSKAKRT--LKNLRV 323

  Fly   377 EITHCGQMRRKYRVCNVTRRPAQMQSFPLQL----ENG--QTVECTVAKYFLDKYRMKLRY-PHL 434
            :::..||   ::::..::.:|.:.|:|.|:.    |||  :|.|.|||.||.|...:.|:| ..|
plant   324 KVSPSGQ---EFKITGLSDKPCREQTFELKKRNPNENGEFETTEVTVADYFRDTRHIDLQYSADL 385

  Fly   435 PCLQVGQEHKHTYLPLEVCNIVAGQRCIKKLTDMQTSTMIKATARSAPDREREINNLVKRADFNN 499
            ||:.||:..:.||:|||:|.:|..||..|.||..|.|.:::.:.:...:|...::..:|.::::.
plant   386 PCINVGKPKRPTYIPLELCALVPLQRYTKALTTFQRSALVEKSRQKPQERMTVLSKALKVSNYDA 450

  Fly   500 DSYVQEFGLTISNSMMEVRGRVLPPPKLQYGGRVSTGLTGQQLFPPQNKVSLASPNQGVWDMRGK 564
            :..::..|::||::..:|.|||||.|||:.|       .|.:.|          |..|.|:...|
plant   451 EPLLRSCGISISSNFTQVEGRVLPAPKLKMG-------CGSETF----------PRNGRWNFNNK 498

  Fly   565 QFFTGVEIRIWAIACFAPQRTVREDALRNFTQQLQKISNDAGMPIIGQPCFCKYATGPD------ 623
            :|....:|:.|.:..|:.:..||:     ....|.||....|:.|...  |..:..|..
plant   499 EFVEPTKIQRWVVVNFSARCNVRQ-----VVDDLIKIGGSKGIEIASP--FQVFEEGNQFRRAPP 556

  Fly   624 --QVEPMFRYLKITFPGL-QLVVVVLPGK--TPVYAEVKRVGDTVLGMATQCVQAKNVNKTSPQT 683
              :||.||:.::...||: |.::.|||.|  :.:|...|:...|..|:.|||:..  ..:.:.|.
plant   557 MIRVENMFKDIQSKLPGVPQFILCVLPDKKNSDLYGPWKKKNLTEFGIVTQCMAP--TRQPNDQY 619

  Fly   684 LSNLCLKINVKLGGINSILVPSIRPK---VFNEPVIFLGADVTHPPAGDNKKPSIAAVVGSMDAH 745
            |:||.||||.||||:||:|.....|.   :...|.|.||.||:|...|.:..|||||||.|.: .
plant   620 LTNLLLKINAKLGGLNSMLSVERTPAFTVISKVPTIILGMDVSHGSPGQSDVPSIAAVVSSRE-W 683

  Fly   746 P--SRYAATVRVQQHRQEIIQEL--------SSMVRELLIMFYKSTGGYKPHRIILYRDGVSEGQ 800
            |  |:|.|:||.|..:.|:|:.|        ..:::|||:.||.|:...||..||::||||||.|
plant   684 PLISKYRASVRTQPSKAEMIESLVKKNGTEDDGIIKELLVDFYTSSNKRKPEHIIIFRDGVSESQ 748

  Fly   801 FPHVLQHELTAIREACIKLEPEYRPGITFIVVQKRHHTRLFCAEKKEQSGKSGNIPAGTTVDVGI 865
            |..||..||..|.|||..|:..:.|....:|.||.|||:.|      |.....|:|.||.:|..|
plant   749 FNQVLNIELDQIIEACKLLDANWNPKFLLLVAQKNHHTKFF------QPTSPENVPPGTIIDNKI 807

  Fly   866 THPTEFDFYLCSHQGIQGTSRPSHYHVLWDDNHFDSDELQCLTYQLCHTYVRCTRSVSIPAPAYY 930
            .||...|||||:|.|:.||:||:|||||:|:..|.:||||.|.:.|.:.|.|.|.::|:.||..|
plant   808 CHPKNNDFYLCAHAGMIGTTRPTHYHVLYDEIGFSADELQELVHSLSYVYQRSTSAISVVAPICY 872

  Fly   931 AHLVAFRARYHLVEKEHDSGEGSHQSGCSEDRTPGAMARAITVHADTKKVMYF 983
            |||.|  |:.....|..|..|.|...|......|.::|:...:..:....|:|
plant   873 AHLAA--AQLGTFMKFEDQSETSSSHGGITAPGPISVAQLPRLKDNVANSMFF 923

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO1	NP_725341.1	ArgoN	146..275	CDD:465134	38/162 (23%)
		ArgoL1	285..335	CDD:462567	19/49 (39%)
		PAZ_argonaute_like	336..456	CDD:239212	42/127 (33%)
		Piwi_ago-like	502..942	CDD:240015	172/463 (37%)
AGO4	NP_565633.1	PLN03202	45..924	CDD:215631	298/927 (32%)