Protein Alignment AGO1 and Ago4

DIOPT Version :10

• Sequence 1: NP_725341.1
• Gene: AGO1 / 36544
• FlyBaseID: FBgn0262739
• Length: 984
• Species: Drosophila melanogaster
• Sequence 2: NP_694817.2
• Gene: Ago4 / 76850
• MGIID: 1924100
• Length: 861
• Species: Mus musculus
• Alignment Length: 870
• Identity: 615/870 - (70%)
• Similarity: 716/870 - (82%)
• Gaps: 29/870 - (3%)

  Fly   128 PDMPVFTCPRRPNLGREGRPIVLRANHFQVTMPRGYVHHYDINIQPDKCPRKVNREIIETMV-HA 191
            |...:|..||||.||..|:||.|.||||||.:|:..|:|||::|:|:|.||:||||:::||| |.
Mouse     8 PPASLFQPPRRPGLGTVGKPIRLLANHFQVQIPKIDVYHYDVDIKPEKRPRRVNREVVDTMVRHF 72

  Fly   192 YSKIFGVLKPVFDGRNNLYTRDPLPIGNERLELEVTLPGEGKDRIFRVTIKWQAQVSLFNLEEAL 256
            ..:|||..:|.:||:.|:||..|||||.:|:::||||||||||:.|:|:::|.:.|||..|.|||
Mouse    73 KMQIFGDRQPGYDGKRNMYTAHPLPIGRDRIDMEVTLPGEGKDQTFKVSVQWVSVVSLQLLLEAL 137

  Fly   257 EGRTRQIPYDAILALDVVMRHLPSMTYTPVGRSFFSSPEGYYHPLGGGREVWFGFHQSVRPSQWK 321
            .|...::|.|::.||||:.||||||.||||||||||.||||||||||||||||||||||||:.|.
Mouse   138 AGHLNEVPDDSVQALDVITRHLPSMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWN 202

  Fly   322 MMLNIDVSATAFYKAQPVIDFMCEVLDIRDINEQRKPLTDSQRVKFTKEIKGLKIEITHCGQMRR 386
            |||||||||||||:|||:|:||||||||::||||.|||||||||||||||:|||:|:||||||:|
Mouse   203 MMLNIDVSATAFYRAQPIIEFMCEVLDIQNINEQTKPLTDSQRVKFTKEIRGLKVEVTHCGQMKR 267

  Fly   387 KYRVCNVTRRPAQMQSFPLQLENGQTVECTVAKYFLDKYRMKLRYPHLPCLQVGQEHKHTYLPLE 451
            ||||||||||||..|:|||||||||.:|||||:||..||.::|::|||||||||||.||||||||
Mouse   268 KYRVCNVTRRPASHQTFPLQLENGQAMECTVAQYFKQKYSLQLKHPHLPCLQVGQEQKHTYLPLE 332

  Fly   452 VCNIVAGQRCIKKLTDMQTSTMIKATARSAPDREREINNLVKRADF--NNDSYVQEFGLTISNSM 514
            ||||||||||||||||.||||||||||||||||:.||:.|||....  ..|.|::|||:.:.|.|
Mouse   333 VCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVKSNSMVGGPDPYLKEFGIVVHNEM 397

  Fly   515 MEVRGRVLPPPKLQYGGRVSTGLTGQQLFPPQNKVSLASPNQGVWDMRGKQFFTGVEIRIWAIAC 579
            .|:.|||||.|.||||||              || ::|:|:|||||||||||:.|:||::||:||
Mouse   398 TELTGRVLPAPMLQYGGR--------------NK-TVATPSQGVWDMRGKQFYAGIEIKVWAVAC 447

  Fly   580 FAPQRTVREDALRNFTQQLQKISNDAGMPIIGQPCFCKYATGPDQVEPMFRYLKITFPGLQLVVV 644
            ||||:..|||.|::||.||:|||.||||||.|||||||||.|.|.|||||::||:|:.||||:||
Mouse   448 FAPQKQCREDLLKSFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFKHLKMTYVGLQLIVV 512

  Fly   645 VLPGKTPVYAEVKRVGDTVLGMATQCVQAKNVNKTSPQTLSNLCLKINVKLGGINSILVPSIRPK 709
            :|||||||||||||||||:|||||||||.|||.|||||||||||||:|.||||||::|||..||.
Mouse   513 ILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKMNAKLGGINNVLVPHQRPS 577

  Fly   710 VFNEPVIFLGADVTHPPAGDNKKPSIAAVVGSMDAHPSRYAATVRVQQHRQEI----------IQ 764
            ||.:||||||||||||||||.|||||||||||||.|||||.||||||..||||          :|
Mouse   578 VFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDGHPSRYCATVRVQTSRQEITQELLYSQEVVQ 642

  Fly   765 ELSSMVRELLIMFYKSTGGYKPHRIILYRDGVSEGQFPHVLQHELTAIREACIKLEPEYRPGITF 829
            :|:||.|||||.||||| .:||.|||.||.||||||...|...||.|||:|||.||.:||||||:
Mouse   643 DLTSMARELLIQFYKST-RFKPTRIIYYRGGVSEGQMKQVAWPELIAIRKACISLEEDYRPGITY 706

  Fly   830 IVVQKRHHTRLFCAEKKEQSGKSGNIPAGTTVDVGITHPTEFDFYLCSHQGIQGTSRPSHYHVLW 894
            ||||||||||||||:|.|:.|||||:|||||||..:|||:|||||||||.|||||||||||.|||
Mouse   707 IVVQKRHHTRLFCADKMERVGKSGNVPAGTTVDSTVTHPSEFDFYLCSHAGIQGTSRPSHYQVLW 771

  Fly   895 DDNHFDSDELQCLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVEKEHDSGEGSHQSGCS 959
            |||.|.:||||.|||||||||||||||||||||||||.|||||||||||:|:|||.||||.||.|
Mouse   772 DDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKDHDSAEGSHVSGQS 836

  Fly   960 EDRTPGAMARAITVHADTKKVMYFA 984
            ..|.|.|:|:|:.:|.||:..||||
Mouse   837 NGRDPQALAKAVQIHHDTQHTMYFA 861

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO1	NP_725341.1	ArgoN	146..275	CDD:465134	69/129 (53%)
		ArgoL1	285..335	CDD:462567	45/49 (92%)
		PAZ_argonaute_like	336..456	CDD:239212	96/119 (81%)
		Piwi_ago-like	502..942	CDD:240015	326/449 (73%)
Ago4	NP_694817.2	ArgoN	26..155	CDD:465134	68/128 (53%)
		ArgoL1	166..216	CDD:462567	45/49 (92%)
		PAZ_argonaute_like	217..337	CDD:239212	96/119 (81%)
		Piwi_ago-like	384..819	CDD:240015	326/450 (72%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	825..846		12/20 (60%)