DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGO1 and ago1

DIOPT Version :9

Sequence 1:	NP_001246314.1	Gene:	AGO1 / 36544	FlyBaseID:	FBgn0262739	Length:	984	Species:	Drosophila melanogaster
Sequence 2:	XP_005158529.2	Gene:	ago1 / 570775	ZFINID:	ZDB-GENE-110606-3	Length:	871	Species:	Danio rerio

Alignment Length:	875	Identity:	630/875 - (72%)
Similarity:	725/875 - (82%)	Gaps:	30/875 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 PATQPDMPVFTCPRRPNLGREGRPIVLRANHFQVTMPRGYVHHYDINIQPDKCPRKVNREIIETM 188
            |...|...||..||||.:|..|:||.|.||:|:|.:|:..|.||:::|:||||||:||||::|.|
Zfish    13 PYPPPLQQVFQAPRRPGMGTVGKPIKLLANYFEVEIPKMDVFHYEVDIKPDKCPRRVNREVVEYM 77

  Fly   189 V-HAYSKIFGVLKPVFDGRNNLYTRDPLPIGNERLELEVTLPGEGKDRIFRVTIKWQAQVSLFNL 252
            | |...::||..|||:||:.|:||...||||:|:::.|||:|||||||||:|:|:|.|:||...|
Zfish    78 VQHFKPQLFGDRKPVYDGKKNIYTVLALPIGSEKVDFEVTIPGEGKDRIFKVSIRWLAKVSWRLL 142

  Fly   253 EEALEGRTRQIPYDAILALDVVMRHLPSMTYTPVGRSFFSSPEGYYHPLGGGREVWFGFHQSVRP 317
            :|.|.....|:|.:::.||||.||||.||.||||||||||.||||||||||||||||||||||||
Zfish   143 QETLVSGRLQVPLESVQALDVAMRHLASMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRP 207

  Fly   318 SQWKMMLNIDVSATAFYKAQPVIDFMCEVLDIRDINEQRKPLTDSQRVKFTKEIK---------- 372
            :.|||||||||||||||||||||:|||||||||:|:||.|.|||||||:||||||
Zfish   208 AMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRNIDEQPKTLTDSQRVRFTKEIKGILQKHSPGV 272

  Fly   373 ---GLKIEITHCGQMRRKYRVCNVTRRPAQMQSFPLQLENGQTVECTVAKYFLDKYRMKLRYPHL 434
               |||:|:||||||:|||||||||||||..|:||||||:|||||||||:||..||.::|:||||
Zfish   273 SFVGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQTVECTVAQYFKQKYNLQLKYPHL 337

  Fly   435 PCLQVGQEHKHTYLPLEVCNIVAGQRCIKKLTDMQTSTMIKATARSAPDREREINNLVKRADFNN 499
            ||||||||.||||||||||||||||||||||||.||||||||||||||||:.||:.|:|.|:||.
Zfish   338 PCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLMKNANFNL 402

  Fly   500 DSYVQEFGLTISNSMMEVRGRVLPPPKLQYGGRVSTGLTGQQLFPPQNKVSLASPNQGVWDMRGK 564
            |.|:||||:.:.:.|.||.|||||.|.||||||              |: ::|:|||||||||||
Zfish   403 DPYIQEFGIKVKDDMTEVTGRVLPAPILQYGGR--------------NR-AIATPNQGVWDMRGK 452

  Fly   565 QFFTGVEIRIWAIACFAPQRTVREDALRNFTQQLQKISNDAGMPIIGQPCFCKYATGPDQVEPMF 629
            ||:.|:||::|||||||||:..||:.|:|||.||:|||.||||||.|||||||||.|.|.|||||
Zfish   453 QFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMF 517

  Fly   630 RYLKITFPGLQLVVVVLPGKTPVYAEVKRVGDTVLGMATQCVQAKNVNKTSPQTLSNLCLKINVK 694
            |:||.|:.||||::|:|||||||||||||||||:|||||||||.|||.|||||||||||||||||
Zfish   518 RHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINVK 582

  Fly   695 LGGINSILVPSIRPKVFNEPVIFLGADVTHPPAGDNKKPSIAAVVGSMDAHPSRYAATVRVQQHR 759
            |||||:||||..|..||.:||||||||||||||||.|||||.|||||||||||||.||||||:.|
Zfish   583 LGGINNILVPHQRSAVFQQPVIFLGADVTHPPAGDGKKPSITAVVGSMDAHPSRYCATVRVQRPR 647

  Fly   760 QEIIQELSSMVRELLIMFYKSTGGYKPHRIILYRDGVSEGQFPHVLQHELTAIREACIKLEPEYR 824
            ||||::||.|||||||.||||| .:||.|||.|||||.|||.|.:|.:||.|||:||||||.:|:
Zfish   648 QEIIEDLSYMVRELLIQFYKST-RFKPTRIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQ 711

  Fly   825 PGITFIVVQKRHHTRLFCAEKKEQSGKSGNIPAGTTVDVGITHPTEFDFYLCSHQGIQGTSRPSH 889
            ||||:||||||||||||||:|.|:.|||||||||||||..||||.|||||||||.||||||||||
Zfish   712 PGITYIVVQKRHHTRLFCADKSERIGKSGNIPAGTTVDTSITHPFEFDFYLCSHAGIQGTSRPSH 776

  Fly   890 YHVLWDDNHFDSDELQCLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVEKEHDSGEGSH 954
            |:||||||.|.:||||.|||||||||||||||||||||||||.|||||||||||:||||||||||
Zfish   777 YYVLWDDNRFTADELQILTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHDSGEGSH 841

  Fly   955 QSGCSEDRTPGAMARAITVHADTKKVMYFA 984
            .||.|..|.|.|:|:|:.:|.|:.:.||||
Zfish   842 VSGQSNGRDPQALAKAVQIHHDSLRTMYFA 871

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGO1	NP_001246314.1	ArgoN	146..275	CDD:406799	68/129 (53%)
		ArgoL1	285..335	CDD:400854	46/49 (94%)
		PAZ_argonaute_like	336..456	CDD:239212	98/132 (74%)
		Piwi_ago-like	502..942	CDD:240015	334/439 (76%)
ago1	XP_005158529.2	PLN03202	1..870	CDD:215631	627/872 (72%)
		ArgoN	27..165	CDD:293095	72/137 (53%)
		ArgoL1	176..225	CDD:285861	45/48 (94%)
		PAZ_argonaute_like	226..359	CDD:239212	98/132 (74%)
		Piwi_ago-like	404..829	CDD:240015	334/440 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	530	1.000	Domainoid score	I273
eggNOG	1	0.900	-	-		E1_KOG1041
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1299	1.000	Inparanoid score	I154
OMA	1	1.010	-	-		QHG58336
OrthoDB	1	1.010	-	-		D159407at2759
OrthoFinder	1	1.000	-	-		FOG0000468
OrthoInspector	1	1.000	-	-		otm25237
orthoMCL	1	0.900	-	-		OOG6_100361
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X379
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.880