Protein Alignment AGO1 and ago3b

DIOPT Version :10

• Sequence 1: NP_725341.1
• Gene: AGO1 / 36544
• FlyBaseID: FBgn0262739
• Length: 984
• Species: Drosophila melanogaster
• Sequence 2: XP_005159513.1
• Gene: ago3b / 568159
• ZFINID: ZDB-GENE-060503-452
• Length: 867
• Species: Danio rerio
• Alignment Length: 884
• Identity: 635/884 - (71%)
• Similarity: 728/884 - (82%)
• Gaps: 31/884 - (3%)

  Fly   111 TTGSVTPAIATATPATQPDMPVFTCPRRPNLGREGRPIVLRANHFQVTMPRGYVHHYDINIQPDK 175
            |||:|..|            |.|:.||||..|..|:||.|.||.|||.:|:..|:.||::|:|:|
Zfish     5 TTGAVGAA------------PQFSVPRRPGYGTMGKPIKLLANCFQVDIPKMDVYLYDVDIKPEK 57

  Fly   176 CPRKVNREIIETMV-HAYSKIFGVLKPVFDGRNNLYTRDPLPIGNERLELEVTLPGE-GKDRIFR 238
            |||:||||::::|| |....|||..:||:||:.:|||..|||:.:..::|:|||||| ||||||:
Zfish    58 CPRRVNREVVDSMVQHFKVTIFGDRRPVYDGKKSLYTAQPLPVASAGVDLDVTLPGEGGKDRIFK 122

  Fly   239 VTIKWQAQVSLFNLEEALEGRT--------RQIPYDAILALDVVMRHLPSMTYTPVGRSFFSSPE 295
            ||||:.:.||...|.|.|.||:        :.|..:.:.|:|||:||||||.|||||||||||||
Zfish   123 VTIKFVSLVSWHMLHEVLTGRSTPDPLELDKPISTNPVHAVDVVLRHLPSMRYTPVGRSFFSSPE 187

  Fly   296 GYYHPLGGGREVWFGFHQSVRPSQWKMMLNIDVSATAFYKAQPVIDFMCEVLDIRDINEQRKPLT 360
            ||.|||||||||||||||||||:.|||||||||||||||||||||.||||||||.:|:||.:|||
Zfish   188 GYDHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIQFMCEVLDIHNIDEQPRPLT 252

  Fly   361 DSQRVKFTKEIKGLKIEITHCGQMRRKYRVCNVTRRPAQMQSFPLQLENGQTVECTVAKYFLDKY 425
            ||.||||||||||||:|:||||.|||||||||||||||..|:||||||||||||.|||:||.:||
Zfish   253 DSHRVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQTFPLQLENGQTVERTVAQYFREKY 317

  Fly   426 RMKLRYPHLPCLQVGQEHKHTYLPLEVCNIVAGQRCIKKLTDMQTSTMIKATARSAPDREREINN 490
            .::|:||||||||||||.||||||||||||||||||||||||.||||||||||||||||:.||:.
Zfish   318 NLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISR 382

  Fly   491 LVKRADFNNDSYVQEFGLTISNSMMEVRGRVLPPPKLQYGGRVSTGLTGQQLFPPQNKVSLASPN 555
            ||:.|::|:|.:||||...:.:.|.||.|||||.|.||||||||:     :.|  .|: ::|:|:
Zfish   383 LVRSANYNSDPFVQEFQFRVRDEMAEVTGRVLPAPMLQYGGRVSS-----EHF--MNR-TVATPS 439

  Fly   556 QGVWDMRGKQFFTGVEIRIWAIACFAPQRTVREDALRNFTQQLQKISNDAGMPIIGQPCFCKYAT 620
            .||||||||||.|||||::|||||||.||..||:.|:.||.||:|||.||||||.|||||||||.
Zfish   440 HGVWDMRGKQFHTGVEIKMWAIACFATQRQCREEVLKGFTDQLRKISKDAGMPIQGQPCFCKYAQ 504

  Fly   621 GPDQVEPMFRYLKITFPGLQLVVVVLPGKTPVYAEVKRVGDTVLGMATQCVQAKNVNKTSPQTLS 685
            |.|.||||||:||.|:.||||::|:|||||||||||||||||:|||||||||.|||.||||||||
Zfish   505 GADNVEPMFRHLKNTYAGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLS 569

  Fly   686 NLCLKINVKLGGINSILVPSIRPKVFNEPVIFLGADVTHPPAGDNKKPSIAAVVGSMDAHPSRYA 750
            ||||||||||||||:||||..||.||.:||||||||||||||||.|||||||||||||||||||.
Zfish   570 NLCLKINVKLGGINNILVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPSRYC 634

  Fly   751 ATVRVQQHRQEIIQELSSMVRELLIMFYKSTGGYKPHRIILYRDGVSEGQFPHVLQHELTAIREA 815
            ||||||:.|||:||:|:||||||||.||||| .|||.|||.||||||||||..||.:||.|||||
Zfish   635 ATVRVQRPRQEVIQDLASMVRELLIQFYKST-HYKPTRIIFYRDGVSEGQFRQVLYYELLAIREA 698

  Fly   816 CIKLEPEYRPGITFIVVQKRHHTRLFCAEKKEQSGKSGNIPAGTTVDVGITHPTEFDFYLCSHQG 880
            ||.||.||:||||:||||||||||||||::.|:.|:|||||||||||..||||.|||||||||.|
Zfish   699 CISLEKEYQPGITYIVVQKRHHTRLFCADRAERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAG 763

  Fly   881 IQGTSRPSHYHVLWDDNHFDSDELQCLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVEK 945
            ||||||||||:||||||.|.:||.|.|||||||||||||||||||||||||||||||||||||:|
Zfish   764 IQGTSRPSHYYVLWDDNCFTADEFQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDK 828

  Fly   946 EHDSGEGSHQSGCSEDRTPGAMARAITVHADTKKVMYFA 984
            ||||.||||.||.|..|.|.|:|:|:.:|.||.:.||||
Zfish   829 EHDSAEGSHVSGQSNGRDPQALAKAVQIHHDTLRTMYFA 867

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO1	NP_725341.1	ArgoN	146..275	CDD:465134	66/138 (48%)
		ArgoL1	285..335	CDD:462567	46/49 (94%)
		PAZ_argonaute_like	336..456	CDD:239212	97/119 (82%)
		Piwi_ago-like	502..942	CDD:240015	339/439 (77%)
ago3b	XP_005159513.1	ArgoN	73..167	CDD:465134	42/93 (45%)
		ArgoL1	177..227	CDD:462567	46/49 (94%)
		PAZ_argonaute_like	228..348	CDD:239212	97/119 (82%)
		Piwi_ago-like	393..825	CDD:240015	339/440 (77%)