DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGO1 and ago3b

DIOPT Version :9

Sequence 1:	NP_001246314.1	Gene:	AGO1 / 36544	FlyBaseID:	FBgn0262739	Length:	984	Species:	Drosophila melanogaster
Sequence 2:	XP_005159513.1	Gene:	ago3b / 568159	ZFINID:	ZDB-GENE-060503-452	Length:	867	Species:	Danio rerio

Alignment Length:	884	Identity:	635/884 - (71%)
Similarity:	728/884 - (82%)	Gaps:	31/884 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 TTGSVTPAIATATPATQPDMPVFTCPRRPNLGREGRPIVLRANHFQVTMPRGYVHHYDINIQPDK 175
            |||:|..|            |.|:.||||..|..|:||.|.||.|||.:|:..|:.||::|:|:|
Zfish     5 TTGAVGAA------------PQFSVPRRPGYGTMGKPIKLLANCFQVDIPKMDVYLYDVDIKPEK 57

  Fly   176 CPRKVNREIIETMV-HAYSKIFGVLKPVFDGRNNLYTRDPLPIGNERLELEVTLPGE-GKDRIFR 238
            |||:||||::::|| |....|||..:||:||:.:|||..|||:.:..::|:|||||| ||||||:
Zfish    58 CPRRVNREVVDSMVQHFKVTIFGDRRPVYDGKKSLYTAQPLPVASAGVDLDVTLPGEGGKDRIFK 122

  Fly   239 VTIKWQAQVSLFNLEEALEGRT--------RQIPYDAILALDVVMRHLPSMTYTPVGRSFFSSPE 295
            ||||:.:.||...|.|.|.||:        :.|..:.:.|:|||:||||||.|||||||||||||
Zfish   123 VTIKFVSLVSWHMLHEVLTGRSTPDPLELDKPISTNPVHAVDVVLRHLPSMRYTPVGRSFFSSPE 187

  Fly   296 GYYHPLGGGREVWFGFHQSVRPSQWKMMLNIDVSATAFYKAQPVIDFMCEVLDIRDINEQRKPLT 360
            ||.|||||||||||||||||||:.|||||||||||||||||||||.||||||||.:|:||.:|||
Zfish   188 GYDHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIQFMCEVLDIHNIDEQPRPLT 252

  Fly   361 DSQRVKFTKEIKGLKIEITHCGQMRRKYRVCNVTRRPAQMQSFPLQLENGQTVECTVAKYFLDKY 425
            ||.||||||||||||:|:||||.|||||||||||||||..|:||||||||||||.|||:||.:||
Zfish   253 DSHRVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQTFPLQLENGQTVERTVAQYFREKY 317

  Fly   426 RMKLRYPHLPCLQVGQEHKHTYLPLEVCNIVAGQRCIKKLTDMQTSTMIKATARSAPDREREINN 490
            .::|:||||||||||||.||||||||||||||||||||||||.||||||||||||||||:.||:.
Zfish   318 NLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISR 382

  Fly   491 LVKRADFNNDSYVQEFGLTISNSMMEVRGRVLPPPKLQYGGRVSTGLTGQQLFPPQNKVSLASPN 555
            ||:.|::|:|.:||||...:.:.|.||.|||||.|.||||||||:     :.|  .|: ::|:|:
Zfish   383 LVRSANYNSDPFVQEFQFRVRDEMAEVTGRVLPAPMLQYGGRVSS-----EHF--MNR-TVATPS 439

  Fly   556 QGVWDMRGKQFFTGVEIRIWAIACFAPQRTVREDALRNFTQQLQKISNDAGMPIIGQPCFCKYAT 620
            .||||||||||.|||||::|||||||.||..||:.|:.||.||:|||.||||||.|||||||||.
Zfish   440 HGVWDMRGKQFHTGVEIKMWAIACFATQRQCREEVLKGFTDQLRKISKDAGMPIQGQPCFCKYAQ 504

  Fly   621 GPDQVEPMFRYLKITFPGLQLVVVVLPGKTPVYAEVKRVGDTVLGMATQCVQAKNVNKTSPQTLS 685
            |.|.||||||:||.|:.||||::|:|||||||||||||||||:|||||||||.|||.||||||||
Zfish   505 GADNVEPMFRHLKNTYAGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLS 569

  Fly   686 NLCLKINVKLGGINSILVPSIRPKVFNEPVIFLGADVTHPPAGDNKKPSIAAVVGSMDAHPSRYA 750
            ||||||||||||||:||||..||.||.:||||||||||||||||.|||||||||||||||||||.
Zfish   570 NLCLKINVKLGGINNILVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPSRYC 634

  Fly   751 ATVRVQQHRQEIIQELSSMVRELLIMFYKSTGGYKPHRIILYRDGVSEGQFPHVLQHELTAIREA 815
            ||||||:.|||:||:|:||||||||.||||| .|||.|||.||||||||||..||.:||.|||||
Zfish   635 ATVRVQRPRQEVIQDLASMVRELLIQFYKST-HYKPTRIIFYRDGVSEGQFRQVLYYELLAIREA 698

  Fly   816 CIKLEPEYRPGITFIVVQKRHHTRLFCAEKKEQSGKSGNIPAGTTVDVGITHPTEFDFYLCSHQG 880
            ||.||.||:||||:||||||||||||||::.|:.|:|||||||||||..||||.|||||||||.|
Zfish   699 CISLEKEYQPGITYIVVQKRHHTRLFCADRAERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAG 763

  Fly   881 IQGTSRPSHYHVLWDDNHFDSDELQCLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVEK 945
            ||||||||||:||||||.|.:||.|.|||||||||||||||||||||||||||||||||||||:|
Zfish   764 IQGTSRPSHYYVLWDDNCFTADEFQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDK 828

  Fly   946 EHDSGEGSHQSGCSEDRTPGAMARAITVHADTKKVMYFA 984
            ||||.||||.||.|..|.|.|:|:|:.:|.||.:.||||
Zfish   829 EHDSAEGSHVSGQSNGRDPQALAKAVQIHHDTLRTMYFA 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGO1	NP_001246314.1	ArgoN	146..275	CDD:406799	66/138 (48%)
		ArgoL1	285..335	CDD:400854	46/49 (94%)
		PAZ_argonaute_like	336..456	CDD:239212	97/119 (82%)
		Piwi_ago-like	502..942	CDD:240015	339/439 (77%)
ago3b	XP_005159513.1	PLN03202	11..866	CDD:215631	628/875 (72%)
		ArgoN	20..167	CDD:293095	70/146 (48%)
		ArgoL1	178..227	CDD:285861	45/48 (94%)
		PAZ_argonaute_like	228..348	CDD:239212	97/119 (82%)
		Piwi_ago-like	393..825	CDD:240015	339/440 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	530	1.000	Domainoid score	I273
eggNOG	1	0.900	-	-		E1_KOG1041
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1299	1.000	Inparanoid score	I154
OMA	1	1.010	-	-		QHG58336
OrthoDB	1	1.010	-	-		D159407at2759
OrthoFinder	1	1.000	-	-		FOG0000468
OrthoInspector	1	1.000	-	-		otm25237
orthoMCL	1	0.900	-	-		OOG6_100361
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X379
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.840