Protein Alignment AGO1 and aub

DIOPT Version :10

• Sequence 1: NP_725341.1
• Gene: AGO1 / 36544
• FlyBaseID: FBgn0262739
• Length: 984
• Species: Drosophila melanogaster
• Sequence 2: NP_476734.1
• Gene: aub / 34524
• FlyBaseID: FBgn0000146
• Length: 866
• Species: Drosophila melanogaster
• Alignment Length: 968
• Identity: 221/968 - (22%)
• Similarity: 392/968 - (40%)
• Gaps: 204/968 - (21%)

  Fly    46 PSPT------RPQSPS--QAQTSFDTLTSPPAPGSSVNPTAVTSPSAQNVAAG----------GA 92
            |:|.      |.:.|:  :|...|     .|:.|...:|    |.|..|.|:|          |.
  Fly     5 PNPVIARGRGRGRKPNNVEANRGF-----APSLGQKSDP----SHSEGNQASGGNGGGGDAQVGP 60

  Fly    93 TVAGAAATAAQVASALGATTGSVT-PAIATATPATQPDMPVFTCPRRPNLGREGRPIVLRANHFQ 156
            ::..::.:|.|:..:.|...|||. ..:.|....::|  |..|..:    |..|..|.::||:|:
  Fly    61 SIEKSSLSAVQMHKSEGDPRGSVRGRRLITDLVYSRP--PGMTSKK----GVVGTHITVQANYFK 119

  Fly   157 V-TMPRGYVHHYDINIQPDKCPRKVNREIIETMVHAYSKIFGVLKPVFDGRN------------- 207
            | ..|...::.|.::..||....::.|    :.::.:..|.|..  :|||.|
  Fly   120 VLKRPNWTIYQYRVDFTPDVEATRLRR----SFLYEHKGILGGY--IFDGTNMFCINQFKAVQDS 178

  Fly   208 ----NLYTRDPLPIGNERLELEVTLPGEGKDRIFRVTIKWQAQVSLFNLEEALEGRTRQIPYDAI 268
                .|.|:..   ..|.:|:::...|.     .:.|...|.||....|..|:||
  Fly   179 PYVLELVTKSR---AGENIEIKIKAVGS-----VQSTDAEQFQVLNLILRRAMEG---------- 225

  Fly   269 LALDVVMRHLPSMTYTPVGRSFFSSPEGYYHP-----LGGGR-EVWFGFHQSVRPSQWKMMLNID 327
            |.|.:|.|:                   ||.|     |...| ::|.|:..|:|..:..::|..:
  Fly   226 LDLKLVSRY-------------------YYDPQAKINLENFRMQLWPGYQTSIRQHENDILLCSE 271

  Fly   328 VSATAFYKAQPVIDFMCEVLDIRDINEQRKPLTDSQRVKFTKEIKGLKIEITHCGQMRRKYRVCN 392
            :..... :.:.:.:.:.:.  |||        :|..:..|.:.:.|:.|...:   ..:.||:.:
  Fly   272 ICHKVM-RTETLYNILSDA--IRD--------SDDYQSTFKRAVMGMVILTDY---NNKTYRIDD 322

  Fly   393 VTRRPAQMQSFPLQLENGQTVECTVAKYFLDKYRMKLRYPHLPC---------LQVGQEHKHTYL 448
            |     ..||.||........|.:...|:..:|.:.:|....|.         ::.|.:.....:
  Fly   323 V-----DFQSTPLCKFKTNDGEISYVDYYKKRYNIIIRDLKQPLVMSRPTDKNIRGGNDQAIMII 382

  Fly   449 PLEVCNIVAGQRCIKKLTDMQTSTMIKATARSAPDRE----REINNLVKRADFNNDSYVQEFGLT 509
            | |:.........::  .|.:|...:....|..|||.    |..|..:|....:.:: ::.:.:.
  Fly   383 P-ELARATGMTDAMR--ADFRTLRAMSEHTRLNPDRRIERLRMFNKRLKSCKQSVET-LKSWNIE 443

  Fly   510 ISNSMMEVRGRVLPPPKLQYGGRVSTGLTGQQLFPPQNKVSLASPNQGVW--DMRGKQFFTGVEI 572
            :.::::|:..|||||.|:.:|        .|::|....:..        |  :.|....|..|.|
  Fly   444 LDSALVEIPARVLPPEKILFG--------NQKIFVCDARAD--------WTNEFRTCSMFKNVHI 492

  Fly   573 RIWAIACFAPQRTVREDALRNFTQQLQKISNDAGMPIIGQPCFCKYATGPDQVEPMFRY----LK 633
            ..|.:  ..|.|.:||  .:.|.|...:.::...|.|    |...|...||.....:..    ..
  Fly   493 NRWYV--ITPSRNLRE--TQEFVQMCIRTASSMKMNI----CNPIYEEIPDDRNGTYSQAIDNAA 549

  Fly   634 ITFPGLQLVVVVLPGKTPVYAEVKRVGDTVLGMATQCVQAKNV--NKTSPQTLSNLCLKI----N 692
            ...|.:.:||:..|.:.. |:.:|:.......:.:|.|..|.:  .:..|..|.::..|:    |
  Fly   550 ANDPQIVMVVMRSPNEEK-YSCIKKRTCVDRPVPSQVVTLKVIAPRQQKPTGLMSIATKVVIQMN 613

  Fly   693 VKLGGIN-SILVPSIRPKVFNEPVIFLGADVTHPPAGDNKKPSIAAVVGSMDAHPS-RYAATVRV 755
            .||.|.. .:::|.       ..::.:|.||.|.|  .||..|..|.|.:||...| ||.:||..
  Fly   614 AKLMGAPWQVVIPL-------HGLMTVGFDVCHSP--KNKNKSYGAFVATMDQKESFRYFSTVNE 669

  Fly   756 QQHRQEIIQELSSMVRELLIMFYKSTGGYKPHRIILYRDGVSEGQFPHVLQHELTAIREACIKLE 820
            ....||:.::: |:.....:..|:......|.||:.:||||.:||...|:..|:..:::   :|:
  Fly   670 HIKGQELSEQM-SVNMACALRSYQEQHRSLPERILFFRDGVGDGQLYQVVNSEVNTLKD---RLD 730

  Fly   821 PEYRPG-------ITFIVVQKRHHTRLFCAEKKEQSGKSGNIPAGTTVDVGITHPTEFDFYLCSH 878
            ..|:..       :|||:|.||.::|.|       :|....:| ||.||..||.|..:||:|.|.
  Fly   731 EIYKSAGKQEGCRMTFIIVSKRINSRYF-------TGHRNPVP-GTVVDDVITLPERYDFFLVSQ 787

  Fly   879 QGIQGTSRPSHYHVLWDDNHFDSDELQCLTYQLCHTYVRCTRSVSIPAPAYYAHLVAF 936
            ....||..|:.|:|:.|:...::|:||.|:|::.|.|...:.::.:||..:|||.:||
  Fly   788 AVRIGTVSPTSYNVISDNMGLNADKLQMLSYKMTHMYYNYSGTIRVPAVCHYAHKLAF 845

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO1	NP_725341.1	ArgoN	146..275	CDD:465134	31/146 (21%)
		ArgoL1	285..335	CDD:462567	10/55 (18%)
		PAZ_argonaute_like	336..456	CDD:239212	22/128 (17%)
		Piwi_ago-like	502..942	CDD:240015	120/456 (26%)
aub	NP_476734.1	PAZ_piwi_like	272..392	CDD:239211	22/139 (16%)
		Piwi_piwi-like_Euk	400..849	CDD:240016	128/493 (26%)