Protein Alignment AGO1 and piwi

DIOPT Version :10

• Sequence 1: NP_725341.1
• Gene: AGO1 / 36544
• FlyBaseID: FBgn0262739
• Length: 984
• Species: Drosophila melanogaster
• Sequence 2: NP_476875.1
• Gene: piwi / 34521
• FlyBaseID: FBgn0004872
• Length: 843
• Species: Drosophila melanogaster
• Alignment Length: 839
• Identity: 205/839 - (24%)
• Similarity: 355/839 - (42%)
• Gaps: 153/839 - (18%)

  Fly   142 GREGRPIVLRANHFQV-TMPRGYVHHYDINIQPDKCPRKVNREIIETMVHAYSKIFGVLKPVFDG 205
            |.:|.|::|:.|.|:: |.|...:.||.:..:|.....:|...::..  ||.....|.|   |||
  Fly    91 GTDGVPVMLQTNFFRLKTKPEWRIVHYHVEFEPSIENPRVRMGVLSN--HANLLGSGYL---FDG 150

  Fly   206 RNNLYTRDPLPIGNERLELEVT-LPGEGK-DRIFRVTIKWQAQVSLFNLEEALEGRTRQIPYDAI 268
            .....||        :.|.|:| |.|:.| |..::::||:...:|      ..|.|..|:
  Fly   151 LQLFTTR--------KFEQEITVLSGKSKLDIEYKISIKFVGFIS------CAEPRFLQV----- 196

  Fly   269 LALDVVMRH-LPSMTYTPVGRSFFSSPEGYYHPLGGGREVWFGFHQSVRPSQWKMMLNIDVSATA 332
              |::::|. :..:....|||:.| .|...........|:|.|:..|:|..:..::|..:::...
  Fly   197 --LNLILRRSMKGLNLELVGRNLF-DPRAKIEIREFKMELWPGYETSIRQHEKDILLGTEITHKV 258

  Fly   333 FYKAQPVIDFM--CEVLDIRDINEQRKPLTDSQRVKFTKEIKGLKIEITHCGQMRRKYRVCNVTR 395
            . :.:.:.|.|  |.....|..:|.|..:.|             .|.:|...  .|.||:.:|
  Fly   259 M-RTETIYDIMRRCSHNPARHQDEVRVNVLD-------------LIVLTDYN--NRTYRINDV-- 305

  Fly   396 RPAQMQSFPLQLENGQTVECTVA---------KYFLDKYRMKLRYPHLP---------CLQVGQE 442
                        :.|||.:.|.:         :|:|.||.:::|..:.|         .|:....
  Fly   306 ------------DFGQTPKSTFSCKGRDISFVEYYLTKYNIRIRDHNQPLLISKNRDKALKTNAS 358

  Fly   443 HKHTYLPLEVCNIV---AGQRC-IKKLTDMQTSTMIKATARSAPDREREINNLVKRADFNNDSYV 503
            .....:| |:|.:.   |..|. .:.:..|.:.|.:....|:  ||.|..|:.::... .:...:
  Fly   359 ELVVLIP-ELCRVTGLNAEMRSNFQLMRAMSSYTRMNPKQRT--DRLRAFNHRLQNTP-ESVKVL 419

  Fly   504 QEFGLTISNSMMEVRGRVLPPPKLQY-GGRVSTGLTG--QQLFPPQNKVSLASPNQGVWDMRGKQ 565
            :::.:.:..::.||:||::....:.: .|:|..|...  |:.|..|.  .|.:|:.|
  Fly   420 RDWNMELDKNVTEVQGRIIGQQNIVFHNGKVPAGENADWQRHFRDQR--MLTTPSDG-------- 474

  Fly   566 FFTGVEIRIWAIACFAPQRTVREDALRNFTQQLQKISNDAGMPIIGQPCFCKY--ATGPDQVEPM 628
                  :..||:  .||||...|  ||.....|.:.::..|:.|.....|..|  .|| ..|..|
  Fly   475 ------LDRWAV--IAPQRNSHE--LRTLLDSLYRAASGMGLRIRSPQEFIIYDDRTG-TYVRAM 528

  Fly   629 FRYLKITFPGLQLVVVVLPG-KTPVYAEVKRVGDTVLGMATQCVQAKNV-NKTSPQTLSNLCLKI 691
            ...:: :.|  :|::.::|. ....|:.:|:.|.....:.||.|..|.. |::.....:.:.:::
  Fly   529 DDCVR-SDP--KLILCLVPNDNAERYSSIKKRGYVDRAVPTQVVTLKTTKNRSLMSIATKIAIQL 590

  Fly   692 NVKLGGINSILVPSIRPKVFNEP---VIFLGADVTHPPAGDNKKPSIAAVVGSMDAHP-SRYAAT 752
            |.|||         ..|.:...|   ::.:|.|:.  .:..::|.:..|::.|||... |.|.:|
  Fly   591 NCKLG---------YTPWMIELPLSGLMTIGFDIA--KSTRDRKRAYGALIASMDLQQNSTYFST 644

  Fly   753 VRVQQHRQEIIQELSSMVRELLIMFYKSTGGYKPHRIILYRDGVSEGQFPHVLQHELTAIREACI 817
            |........:...|..|:.:.|.. |:......|.||:.||||||.|....:.:.|:..|.|
  Fly   645 VTECSAFDVLANTLWPMIAKALRQ-YQHEHRKLPSRIVFYRDGVSSGSLKQLFEFEVKDIIE--- 705

  Fly   818 KLEPEYR------PGITFIVVQKRHHTRLFCAEKKEQSGKSGNIPAGTTVDVGITHPTEFDFYLC 876
            ||:.||.      |.:.:|||.:..:||.|.      :|:  |.|.||.||..||.|..:||||.
  Fly   706 KLKTEYARVQLSPPQLAYIVVTRSMNTRFFL------NGQ--NPPPGTIVDDVITLPERYDFYLV 762

  Fly   877 SHQGIQGTSRPSHYHVLWDDNHFDSDELQCLTYQLCHTYVRCTRSVSIPAPAYYAHLVA 935
            |.|..|||..|:.|:||:.......:::|.|||::||.|...:.:..:||...||..:|
  Fly   763 SQQVRQGTVSPTSYNVLYSSMGLSPEKMQKLTYKMCHLYYNWSGTTRVPAVCQYAKKLA 821

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO1	NP_725341.1	ArgoN	146..275	CDD:465134	33/131 (25%)
		ArgoL1	285..335	CDD:462567	11/49 (22%)
		PAZ_argonaute_like	336..456	CDD:239212	27/139 (19%)
		Piwi_ago-like	502..942	CDD:240015	122/451 (27%)
piwi	NP_476875.1	PAZ	262..396	CDD:198017	31/163 (19%)
		Piwi_piwi-like_Euk	382..826	CDD:240016	129/490 (26%)