Protein Alignment AGO1 and AGO3

DIOPT Version :9

• Sequence 1: NP_001246314.1
• Gene: AGO1 / 36544
• FlyBaseID: FBgn0262739
• Length: 984
• Species: Drosophila melanogaster
• Sequence 2: NP_001036627.2
• Gene: AGO3 / 3355150
• FlyBaseID: FBgn0250816
• Length: 867
• Species: Drosophila melanogaster
• Alignment Length: 927
• Identity: 204/927 - (22%)
• Similarity: 364/927 - (39%)
• Gaps: 237/927 - (25%)

  Fly    79 VTSPSAQNVAAGGATVAGAAATAAQVASALGATTGSVTPAIATATPATQPDMPVFTCPRRPNLGR 143
            :||.|.:|:..                    .|.|..:.|||:......||: ::        |.
  Fly    88 ITSESKENITK--------------------KTKGPESEAIASENGLFFPDL-IY--------GS 123

  Fly   144 EGRPIVLRANHFQVTMPRGY-VHHYDINIQPDKCPRKVNREIIETMVHAYSKIFGVLK------P 201
            :|..:.:..|:.::|..... |.:|::...|.          |:: ||...|.....|      .
  Fly   124 KGSSVNIYCNYLKLTTDESKGVFNYEVRFFPP----------IDS-VHLRIKYLNDHKDKLGGTK 177

  Fly   202 VFDGRNNLYTRDPLPIGN---------ERLELEVTLPGEGKDRIFRVTIKWQAQVSLFNLEEALE 257
            .||| |.||.  |:.:.|         |.:||::.:..:.|:.:...|       .|:|
  Fly   178 TFDG-NTLYL--PILLPNKMTVFISKAEDVELQIRILYKKKEEMRNCT-------QLYN------ 226

  Fly   258 GRTRQIPYDAILALDVVMRHLPSMTYTPVGRSFFSSPEGYYHPLGGGREVWFGFHQSVRPSQWKM 322
                 |.:|.::.:         :.|....|..|........|| ...|||.|:..:|...:..:
  Fly   227 -----ILFDRVMKV---------LNYVKFDRKQFDPSRPKIIPL-AKLEVWPGYVTAVDEYKGGL 276

  Fly   323 MLNIDVSATAFYKAQPVIDFMCE--VLD-IRDINEQRKPLTDSQRVKFTKEIKGLKIEITHCGQM 384
            ||..|||..          .:|:  ||: :.|:.:|                     .:.|..:.
  Fly   277 MLCCDVSHR----------ILCQKTVLEMLVDLYQQ---------------------NVEHYQES 310

  Fly   385 RRKYRVCNVTRRPAQMQSFPL-------------QLENGQTVECT-VAKYFLDKYRMKLRYPHLP 435
            .||..|.|:.......:::.:             :::.|    || ..:|:...:.:.::..:.|
  Fly   311 ARKMLVGNIVLTRYNNRTYKINDICFDQNPTCQFEIKTG----CTSYVEYYKQYHNINIKDVNQP 371

  Fly   436 CLQVGQEHKHTYLPLEVCNIVAGQRCI------------------KKLTDMQTSTMIKATARSAP 482
            .:.  ...|...:|.|..|:   |.|:                  |.:.::.|.|.:     |..
  Fly   372 LIY--SIKKSRGIPAERENL---QFCLIPELCYLTGLRDEVRSDNKLMREIATFTRV-----SPN 426

  Fly   483 DREREINNLVKRADFNNDSYVQE----FGLTISNSMMEVRGRVLPPPKLQYGGRVSTGLTGQQLF 543
            .|:..:|...:  :.:|....||    :||:::|:..::.||.:...::.:
  Fly   427 QRQMALNKFYE--NVSNTPAAQEILNSWGLSLTNNSNKISGRQMDIEQIYF-------------- 475

  Fly   544 PPQNKVSLASPNQGVWDMRG--KQFFTGVEIRIWAIACFAPQRTVREDALRNFTQQLQKISNDAG 606
               :|:|:::.....:....  .:....|.:..|.|......|......|.|..|..:.:..:..
  Fly   476 ---SKISVSAGRSAEFSKHAVTNEMLKVVHLSKWIIIHLRNYRQAATSLLDNMKQACESLGMNIS 537

  Fly   607 MPIIGQPCFCKYATGPDQVEPMFRYLK--ITFPGLQLVVVVLPGKTPVYAEVKRVGDTVLGMATQ 669
            .|.:       .:...|:::...:.|:  ||.....:|.:....:...||.:|::..:.:.:.:|
  Fly   538 NPTM-------ISLDHDRIDAYIQALRRNITMNTQMVVCICHNRRDDRYAAIKKICCSEIPIPSQ 595

  Fly   670 CVQAKNVNKTSP--QTLSNLCLKINVKLGG-INSILVPSIRPKVFNEPVIFLGADVTHPPAGDNK 731
            .:.||.:.....  ..:..:.|::|.|||| :.::.:|.       :.|:..|.|..|.|:  |:
  Fly   596 VINAKTLQNDLKIRSVVQKIVLQMNCKLGGSLWTVKIPF-------KNVMICGIDSYHDPS--NR 651

  Fly   732 KPSIAAVVGSMDAHPSRYAATVRVQQHRQEIIQELSSMVRELLIMFYKSTGGYKPHRIILYRDGV 796
            ..|:||.|.|:::..|::.:...||..|:||:..||:.. |:.:..|:...|..|..||:||||:
  Fly   652 GNSVAAFVASINSSYSQWYSKAVVQTKREEIVNGLSASF-EIALKMYRKRNGKLPTNIIIYRDGI 715

  Fly   797 SEGQFPHVLQHELTAIREAC---IKLEPEYRPGITFIVVQKRHHTRLFCAEKKEQSGKSG----N 854
            .:||....|.:|:......|   ||        |::||||||.:||:|       || ||    |
  Fly   716 GDGQLYTCLNYEIPQFEMVCGNRIK--------ISYIVVQKRINTRIF-------SG-SGIHLEN 764

  Fly   855 IPAGTTVDVGITHPTEFDFYLCSHQGIQGTSRPSHYHVLWDDNHFDSDELQCLTYQLCHTYVRCT 919
            ...||.||..||....:||:|.|....|||..|:||.||.||.::..|.:|.|:|:||..|....
  Fly   765 PLPGTVVDQHITKSNMYDFFLVSQLVRQGTVTPTHYVVLRDDCNYGPDIIQKLSYKLCFLYYNWA 829

  Fly   920 RSVSIPAPAYYAHLVAF 936
            .:|.|||...|||.:|:
  Fly   830 GTVRIPACCMYAHKLAY 846

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO1	NP_001246314.1	ArgoN	146..275	CDD:406799	27/144 (19%)
		ArgoL1	285..335	CDD:400854	14/49 (29%)
		PAZ_argonaute_like	336..456	CDD:239212	19/136 (14%)
		Piwi_ago-like	502..942	CDD:240015	121/453 (27%)
AGO3	NP_001036627.2	PAZ	291..425	CDD:198017	23/168 (14%)
		Piwi_piwi-like_Euk	412..850	CDD:240016	128/492 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910